Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

Dinçol, Muzaffer Emir; Özbaş, Hakan; Yilmaz, Bülent; Ersev, Handan; Gökyay, Selçuk; Olgaç, Vakur

doi:10.1186/s12903-016-0302-0

Cited by 9 publications

(5 citation statements)

References 33 publications

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“…Meanwhile, other research evaluated natural substances, similar to our study. ABS is a licensed product with a local hemostatic effect [22]. ABS is available as wound dressing, ampoule, and spray form.…”

Section: Discussionmentioning

confidence: 99%

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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Background/aim To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing. Materials and methods A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program. P < 0.05 was considered significant. Results The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3, respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score, mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003). Conclusion ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.

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Section: Discussionmentioning

confidence: 99%

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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“…Although aloe vera gel and lotus root powder already possess skin-friendly qualities, the addition of thickeners and natural preservatives further enhances their interaction with the skin ( Figure 1 ). Furthermore, including a natural preservative like Geogard 221 ensures product stability for at least six months, inhibiting microbial growth [ 41 ]. This strengthens the preservation and safety aspects of the product, providing a secure solution for users.…”

Section: Introductionmentioning

confidence: 99%

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Shin,

Hillyer,

Shin

2024

Gels

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Bleeding resulting from surgical procedures or trauma, including gunshot wounds, represents a life-threatening health issue. Therefore, the development of safe, effective, and convenient hemostatic agents is critical in securing the “golden time” to save patients’ lives. Plant-derived compounds and plant extracts have been regarded as promising sources of hemostatic agents in previous studies, regulating hemostatic function with low toxicity and minimal side effects within the human body. Aloe vera-based hydrogels, which are characterized by flexible strength and high functionality, have emerged as a promising platform for wound applications due to their unique biocompatibility features. This study provides a comprehensive exploration of the utilization of thickening agents and natural agents such as xanthan gum, carrageenan, Carbomer, and alginate in applying aloe vera-based hydrogels as a hemostatic. Furthermore, it also tests the use of aloe vera-based hydrogels for therapeutic delivery at wound sites through the incorporation of various antimicrobial agents to extend the utility of the hydrogels beyond hemostasis. Our novel applied research utilizes aloe vera-based hydrogel as an antimicrobial hemostatic agent, providing valuable insights for a wide range of applications and highlighting its potential to enhance hemorrhage control in various emergency scenarios.

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“…While ABS has been used in traditional Turkish medicine for centuries, it has recently been approved by the Turkish Ministry of Health for medical use (6,7). It is used for lung, cardiac surgery, gastrointestinal system, urological surgeries, ENT surgery, and dentistry (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

Egemen

Dere

Koluman

et al. 2022

Batı Karadeniz Tıp Dergisi

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Aim: Haemostasis is a vital stage for the success of the surgery. Although Ankaferd Blood Stopper (ABS), a low-cost and reliable agent, is used in many surgeries, it is not yet available for use in the intracranial area. This study aims to reveal ABS’s cytotoxic effects and safety profile in mammalian brain parenchyma. Material and Methods: 30 Wistar Albino rats were divided into three groups consisting of 10 rats. Haemostasis was achieved with saline in group 1, 50% diluted ABS in group 2, and 100% ABS in group 3 in bleeding caused by damage to the brain parenchyma. Urotensin, Antithrombin III (AT3) and fibrinogen were studied in blood samples taken before surgery and during sacrification. In addition, the histologic examination was performed after the sacrification of rats and injury scores were assessed. Results: Fibrinogen levels in groups 2 and 3 were significantly higher than group 1 in blood samples taken before surgery. There was a significant increase in urotensin during sacrification compared to the pre-surgical period in all three groups. (p=0.005) Slight injury in group 2, mild injury in group 3, and severe injury in group 1 were statistically significantly higher. (p=0.005) These results indicate that the use of 50% diluted ABS is safe. Conclusion: ABS, used for the first time in the mammalian brain parenchyma, was evaluated as safe in rats. Compared to haemostatic matrix agents, in addition to safety and efficacy, its low cost might increase its clinical use in the future.

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Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

Cited by 9 publications

References 33 publications

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Rational Design and Testing of Antibacterial Aloe Vera Hemostatic Hydrogel

Ankaferd® Kanama Durdurucunun Beyin Parankiminde Hemostatik Etkisi: Deneysel Çalışma

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