Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice

Abstract

Abstract. BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study examined the effect of BP-C3 (80 mg/kg, administered 18 times in total by gavage) on the development of haematological and intestinal manifestations of toxicity following 5-fluorouracil (5-FU; 150 mg/kg, administered once via intravenous injection) administration in outbred male Swiss-H Rappolovo (SHR) mice. The use of BP-C3 on therapeutic and preventative/therapeutic schedules demonstrated that it was protective against the toxic effect of 5-FU exerted on the lymphopoietic organs. Administering ВР-С3 24 h after 5-FU (therapeutic schedule) had an effect on the recovery of leukopoiesis and prevented anaemia in the mice. In the mice that received 5-FU and 5-FU with BP-C3 prior to and following administration of the chemotherapeutic agent (preventative/therapeutic schedule), mild anaemia developed by day 7. Administration of BP-C3 without 5-FU did not affect blood cell differentiation in the mice. Thus, BP-C3, depending on the administration schedule, had different effects on the haematological parameters of haematopoietic organs and peripheral blood in mice exposed to 5-FU. BP-C3 promoted intestinal crypt survival when administered on the preventative/therapeutic and therapeutic schedules, suggesting that the formulation protects the epithelium of the small intestine against damage by 5-FU.

The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene

“…In the present study, BP-C3 was less efficient in protecting laboratory animals from the hematological toxicity induced by CPA than in the previously reported study where BP-C3 was administered to animals treated with 5-fluorouracil. 3 The results of our study confirm the earlier reported antitumor effect of polyphenolic compounds by demonstrating the antitumor activity of the lignin-derived polyphenolic composition BP-C3 in male mice with soft tissue sarcomas. BP-C3 does not have a significant effect on the proliferative rate of the soft tissue sarcomas, while the addition of BP-C3 to a CPA regimen allows a decrease in tumor vasculature.…”

“…In our previous studies, we have demonstrated the activity of BP-C3 against the hematological toxicity induced by 5-fluorouracil: BP-C3 prevented the development of anemia in SHR mice exposed to 5-fluorouracil. 3…”

The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

“…C19 significantly decreased tumor growth and much more efficient than the currently used chemotherapeutic agent 5-Fu, which also showed significant toxicity in mice [ 36 ]. 5-Fu is effective against some types of intestinal cancers such as colorectal cancer where it is primarily associated with tissue damaging and regenerating effects in the gastrointestinal mucosa [ 37 ]. FOLFOX4 is a combination chemotherapy regimen involving administration of oxaliplatin in combination with 5-FU and leucovorin; this regimen is reportedly active in patients who have been previously treated with 5-FU alone or in combination with leucovorin.…”

Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets in silico and in vitro

“…BP-C3 is a composition of BP-Cx-1 with iron complex, selenium, ascorbic acid, and retinol. It exhibits geroprotective activity [ 19 ] and reduces 5-fluorouracil toxicity in mice by accelerating recovery of leukopoiesis and protecting small intestine epithelium [ 20 ].…”