Metal direct writing in semi-solid slurry is an innovative technology to realize low-cost printing of load-bearing parts in contrast to laser-based additive manufacturing. However, it is challenging to achieve near net-forming of 3D parts in the current stage because of the out of controlled microstructure and hence the unstable macro extrusion of the used semi-solid slurry. Here, mixed powder remelting (MPR) is introduced to actively design the characteristics of solid phases, i.e., solid fraction, shape factor, and size distribution. Specifically, high-melting-point pure Al powder served as the dispersed solid phases in the liquid phase that transformed from Al-Si alloy powder after remelting, leading to hypoeutectic Al-Si semi-solid slurry. The effectiveness of this approach was experimentally examined and kinetically modelled, to prepare semi-solid slurry with pre-set microstructure. The improved extrusion stability of semi-solid slurry can be anticipated, and it is universal for manufacturing of metal matrix composites slurry.