Effect of three different amines on the surface properties of electrospun polycaprolactone mats

Toledo, Anna Lecticia Martinez Martinez; Ramalho, B. S.; Picciani, Paulo H. S.; Baptista, Leandra Santos; Martínez, Ana Maria Blanco; Dias, Marcos L.

doi:10.1080/00914037.2020.1785463

Cited by 20 publications

(19 citation statements)

References 78 publications

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“…In the biomolecules grafting method, collagen type I (Col I), nanohydroxyapatite (nHA), fibrin, and chitosan are components that might be covalently incorporated into the polymer surface [ 56 , 57 , 58 , 59 , 60 , 61 ]. Chen et al [ 62 ] treated PLLA nanofibers with oxygen plasma to expose –COOH groups on the surface and subsequently, by covalent grafting, cationized gelatin was incorporated into the fiber’s surface using an appropriate coupling agent (carbodiimide).…”

Section: Surface Functionalization Methodsmentioning

confidence: 99%

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

2020

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Electrospun polymer nanofibers have received much attention in tissue engineering due to their valuable properties such as biocompatibility, biodegradation ability, appropriate mechanical properties, and, most importantly, fibrous structure, which resembles the morphology of extracellular matrix (ECM) proteins. However, they are usually hydrophobic and suffer from a lack of bioactive molecules, which provide good cell adhesion to the scaffold surface. Post-electrospinning surface functionalization allows overcoming these limitations through polar groups covalent incorporation to the fibers surface, with subsequent functionalization with biologically active molecules or direct deposition of the biomolecule solution. Hydrophilic surface functionalization methods are classified into chemical approaches, including wet chemical functionalization and covalent grafting, a physiochemical approach with the use of a plasma treatment, and a physical approach that might be divided into physical adsorption and layer-by-layer assembly. This review discusses the state-of-the-art of hydrophilic surface functionalization strategies of electrospun nanofibers for tissue engineering applications. We highlighted the major advantages and drawbacks of each method, at the same time, pointing out future perspectives and solutions in the hydrophilic functionalization strategies.

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Section: Surface Functionalization Methodsmentioning

confidence: 99%

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

2020

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“…The reaction between polyesters and diamines is frequently used as an effective method for introducing NH 2 groups on the scaffold surface. 18,19 Its application is not limited to tissue engineering. Aminolysis is used in the textile industry to enhance fibers dyeing ability.…”

Section: Introductionmentioning

confidence: 99%

Aminolysis as a surface functionalization method of aliphatic polyester nonwovens: impact on material properties and biological response

et al. 2022

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Section: Resultsmentioning

confidence: 99%

“…The fusion of collagen was able to improve the cytocompatibility. Surface modification via aminolysis has been commonly employed to enhance cell proliferation without property alteration [12,30]. Concerning the increasing drift along the concentrations, the highest cell proliferation rate was acquired on scaffolds with 12.5 wt% collagen with cell count of 6.9 × 10 5 cells/mL.…”

Section: Plga/collagen Nanofibersmentioning

confidence: 99%

Elucidation of Antimicrobial Silver Sulfadiazine (SSD) Blend/Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) Immobilised with Collagen Peptide as Potential Biomaterial

et al. 2020

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The quest for a suitable biomaterial for medical application and tissue regeneration has resulted in the extensive research of surface functionalization of material. Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial polymer well-known for its high levels of biocompatibility, non-genotoxicity, and minimal tissue response. We have designed a porous antimicrobial silver SSD blend/poly(3HB-co-4HB)-collagen peptide scaffold using a combination of simple techniques to develop a scaffold with an inter-connected microporous pore in this study. The collagen peptide was immobilised via -NH2 group via aminolysis. In order to improve the antimicrobial performance of the scaffold, silver sulfadiazine (SSD) was impregnated in the scaffolds. To confirm the immobilised collagen peptide and SSD, the scaffold was characterized using FTIR. Herein, based on the cell proliferation assay of the L929 fibroblast cells, enhanced bioactivity of the scaffold with improved wettability facilitated increased cell proliferation. The antimicrobial activity of the SSD blend/P(3HB-co-4HB)-collagen peptide in reference to the pathogenic Gram-negative, Gram-positive bacteria and yeast Candida albicans exhibited SSD blend/poly(3HB-co-4HB)-12.5 wt% collagen peptide as significant construct of biocompatible antibacterial biomaterials. Thus, SSD blend/P(3HB-co-4HB)-collagen peptide scaffold from this finding has high potential to be further developed as biomaterial.

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Effect of three different amines on the surface properties of electrospun polycaprolactone mats

Cited by 20 publications

References 78 publications

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering

Aminolysis as a surface functionalization method of aliphatic polyester nonwovens: impact on material properties and biological response

Elucidation of Antimicrobial Silver Sulfadiazine (SSD) Blend/Poly(3-Hydroxybutyrate-co-4-Hydroxybutyrate) Immobilised with Collagen Peptide as Potential Biomaterial

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