Effect of thymol on peripheral blood mononuclear cell PBMC and acute promyelotic cancer cell line HL-60

Antioxidant and Antiproliferative Properties of the Essential Oils of Satureja thymbra and Satureja parnassica and their Major Constituents

“…It has been studied for its activity against several cancer lines, including HL-60 acute promyelotic leukemia cells, B16-F10 cells and finally P-815, K-562, CEM and MCF-7 cell lines. Thymol affected the viability of HL-60 cells after 24-h incubation, causing concentration-dependent apoptosis (38). B16-F10 melanoma cells exhibited the same sensitivity to thymol in two separate studies (39).…”

Biological effects of four frequently used medicinal plants of Lamiaceae

“…The oil alone did not induce any significant changes in the biochemical parameters, while the combined treatment showed significant improvements in all tested parameters and histological pictures in the liver tissues. Antispasmodic, antibacterial and anti-inflammatory activity of thymol has been reported by Deb et al [22]. Previous investigations on thymol have indicated its cytoprotective activity against radiation-induced damage in in vitro and in vivo model systems.…”

“…Treatment of cells with thymol resulted in activation of initiator caspase-8 and -9, effector caspase-3 and then intracellular substrate, poly(ADP-ribose)polymerase (PARP) cleavage, resulting in apoptosis. Moreover, thymol was also able to induce caspase-independent apoptosis [22]. Research of Ferraz et al [99] showed cytotoxicity of Lippia gracilis EO treatment on HepG2 cells.…”

“…It is noteworthy that mitochondria play a vital role in induction of apoptosis through release of proteins that propagate both caspase-dependent and caspase-independent pathways. Deb et al [22] reported on the anticancer activity of thymol on acute promyelotic leukemia HL-60 cells but did not show any cytotoxic effect in peripheral blood mononuclear cells. The cytotoxic effect of thymol on HL-60 cells appears to be associated with induction of cell cycle arrest at sub G0/G1 phase which is irreversible and leads the cell to undergo apoptosis.…”

Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol

“…In addition, the compounds having phenol functional group are known to have anticancer, antibacterial, antiviral, antifungal and antioxidant activities [7][8][9] . Thymol, 2-isopropyl-5-methylphenol, is a bioactive natural phenolic compound which was isolated from Thymus sulgaris Thymol is known to show antioxidant [11][12][13] , anticancer 14,15 , antidepressant 16 , antibacterial 17,18 C NMR (100 MHz) spectra were taken using a Varian Mercury Plus spectrometer (Varian Inc., Palo Alto, CA). Chemical shifts (d) were reported in ppm.…”