Effect of thyroidectomy on the histology of rat sublingual gland

Abstract

This study was carried out to investigate the effect of thyroidectomy on the histology of rat sublingual gland. Twenty-eight male Wistar albino rats, aged 4 weeks and weighing between 45-55 g, were used. The rats were divided into two experimental groups (control and thyroidectomy), each containing 14 animals. Total thyroidectomy of rats was performed under ether anesthesia in thyroidectomy group. The rats in the control group were sham operated without having the thyroidectomy. Seven rats randomly selected from both groups were fixed using the perfusion fixation technique 2 and 6 weeks after thyroidectomy, and their sublingual glands were harvested for histological investigation. No histological difference was observed between the two groups 2 weeks after thyroidectomy. However, 6 weeks after thyroidectomy considerable cytoplasmic vacuolization of the epithelial cells of the mucous tubules was seen in the thyroidectomy group compared to the controls. Enlargement of mucous tubules was also observed, and the lumina in most of the tubules was quite dilated. In the stroma surrounding the parenchymal tissues, increased lipid tissue mass was observed. In addition, increased connective tissue mass and mononuclear cell infiltrations were evident. Furthermore, the number of mast cells was significantly higher in the thyroidectomy group than in the controls 6 weeks after thyroidectomy. It was concluded that the thyroid gland and hormones might have an influence on the histology of the sublingual gland.

Comparative study of the effect of experimentally induced hyperthyroidism and hypothyroidism on the parotid gland in adult male albino rats

“…Also in hypothyroid rats acini were widely separated [31] . This was clarified by Oncu et al (2004) [24] who observed atrophy of acini and Hayat et al (2010) who declared an increase in the amount of inter acinar & interlobular connective tissue in hypothyroidism [13,24] . Intense vacuolation was observed in semithin sections of hypothyroid glands but mild vacuolation was observed in hyperthyroid rats.…”

“…Sections were stained with Haematoxylin and Eosin (H & E) for routine histological study. Toluidine blue staining technique was used for the mast cells examination [24] . Sections were examined with the light microscope and photographed with the Lecia ICC50 W camera.…”

Donepezil Improves Histological and Biochemical Changes in the Hippocampus of Adult Hypothyroid Male Rats

“…It is well established that the cholinergic system is involved in higher brain functions such as learning and memory. Some authors' results demonstrated that T4 and DON administered in combination resulted in more effective restoration levels of ACh and synaptic proteins than either alone [14,19,45,46] Oxidative stress is an imbalance between the production of oxidizing agents and antioxidant activity of defence systems. Mitochondria are the core cell organelle that uses oxygen to produce energy.…”

“…The parathyroids were preserved and received post operative treatment. The sham group (euthyroid animals) underwent the same procedure without thyroid removal [19] .…”

Eltroxin Like Mimic Action of Withania Somnifera Leaf Extract in Hypothyroid-Induced Rats

“…It is defined as a condition when the level of the thyroid hormones decreases below the normal need of the body [2]. The hypothyroidism is a complex hormonal dysfunction rather than a single hormonal defect [3]. Thyroid hormone is a powerful modulator of cardiac function [4].…”