Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Kivirikko, BY Kari I.; Koivusalo, Martti; Laitinen, Ossi; Liesmaa, Martti

doi:10.1111/j.1748-1716.1963.tb02609.x

Cited by 22 publications

(11 citation statements)

References 18 publications

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“…Hydroxyproline concentration determination for total collagen content was performed in kidney lysates as described from Kivirikko et al [31]. Briefly, tissue was lysed in 1% Triton, 4 mM EDTA, 1% protease inhibitor cocktail II (Sigma Chemicals) and homogenized with a prechilled mortar and pestle.…”

Section: Methodsmentioning

confidence: 99%

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

et al. 2012

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Exacerbated oxidative stress and inflammation may induce three types of programmed cell death, autophagy, apoptosis and pyroptosis in unilateral ureteral obstruction (UUO) kidney. Sulforaphane activating NF-E2-related nuclear factor erythroid-2 (Nrf-2) signaling may ameliorate UUO-induced renal damage. UUO was induced in the left kidney of female Wistar rats. The level of renal blood flow, cortical and medullary oxygen tension and reactive oxygen species (ROS) was evaluated. Fibrosis, ED-1 (macrophage/monocyte) infiltration, oxidative stress, autophagy, apoptosis and pyroptosis were evaluated by immunohistochemistry and Western blot in UUO kidneys. Effects of sulforaphane, an Nrf-2 activator, on Nrf-2- and mitochondrial stress-related proteins and renal injury were examined. UUO decreased renal blood flow and oxygen tension and increased renal ROS, 3-nitrotyrosine stain, ED-1 infiltration and fibrosis. Enhanced renal tubular Beclin-1 expression started at 4 h UUO and further enhanced at 3d UUO, whereas increased Atg-5-Atg12 and LC3-II expression were found at 3d UUO. Increased renal Bax/Bcl-2 ratio, caspase 3 and PARP fragments, apoptosis formation associated with increased caspase 1 and IL-1β expression for pyroptosis formation were started from 3d UUO. UUO reduced nuclear Nrf-2 translocation, increased cytosolic and inhibitory Nrf-2 expression, increased cytosolic Bax translocation to mitochondrial and enhanced mitochondrial Cytochrome c release into cytosol of the UUO kidneys. Sulforaphane significantly increased nuclear Nrf-2 translocation and decreased mitochondrial Bax translocation and Cytochrome c release into cytosol resulting in decreased renal injury. In conclusion, sulforaphane via activating Nrf-2 signaling preserved mitochondrial function and suppressed UUO-induced renal oxidative stress, inflammation, fibrosis, autophagy, apoptosis and pyroptosis.

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Section: Methodsmentioning

confidence: 99%

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

et al. 2012

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“…Such a mechanism might explain the only slight increase in hydroxyproline excretion in our patient (Case 12, Table I) after the injection ofgrowth hormone. Kivirikko et al (1963Kivirikko et al ( , 1967a and Kivirikko, Koivusalo, and Laitinen (1964) consider that the low hydroxyproline excretion in hypothyroid Hydroxyproline excretion in various forms of growth failure individuals may be due to decreased synthesis of collagen in addition to diminished catabolism. and Mirouze et al (1971) found a good correlation between PBI levels and urinary hydroxyproline excretion.…”

Section: Resultsmentioning

confidence: 99%

Hydroxyproline excretion in various forms of growth failure.

Teller¹,

Genscher²,

Burkhardt³

et al. 1973

Archives of Disease in Childhood

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. Hydroxyproline excretion in various forms of growth failure. The hydroxyproline excretion in 24-hour urines was determined in 26 children and adolescents whose heights were below the 3rd centile. In 14 growth failure was related to endocrine defects, and in 12 growth failure was unrelated to endocrine defect. The normal range of urinary hydroxyproline excretion at different ages was determined in 40 normal children aged between 3 and 14 years. All subjects were placed on a hydroxyproline-free diet before and during urine collections. Hydroxyproline excretion was expressed as mg/m2 body surface per 24 hr.Children with pituitary and hypothyroid dwarfism had decreased excretion of hydroxyproline. Giving growth hormone and/or thyroid hormone raised the hydroxyproline excretion to normal. Children with growth failure unrelated to endocrine defect had normal hydroxyproline excretion.During childhood, urinary hydroxyproline excretion provides a useful means for distinguishing between endocrine dwarfism (low excretion) and non-endocrine dwarfism (normal excretion). In older adolescents and adults it is less reliable.The amino acid hydroxyproline is formed by hydroxylation of proline within the collagen (for review see Adams, 1970), and 95% of urinary hydroxyproline is derived from collagen in bones. Under conditions of a hydroxyproline-free diet the urinary excretion of hydroxyproline can be considered a parameter of bone metabolism and bone growth (for reviews see Kivirikko, 1970;Sjoerdsma et al., 1965).Varying levels of hydroxyproline in 24-hour urines have been described in connexion with several skeletal disorders (Burkhardt, Dietrich, and Rommel, 1970;Filliat et al., 1965;Haddad, Couranz, and Avioli, 1970;Laitinen, Nikkila, and Kivirikko, 1966;Nakagawa et al., 1967; RuizTorres, 1969;Smiley and Ziff, 1964). Decreased hydroxyproline excretion has been described in hypopituitary and hypothyroid dwarfs (Chiumello and Del

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“…Increased rates of hydroxyproline excretion has been observed in hyperthyroidism (13) and in patients after administration of thyroid hormone ( 14). Conversely, decreased levels of hydroxyproline excretion have been reported in patients with hypothyroidism ( 1 5 ) and in animals with experimental h y pthyroidism ( 16).…”

Section: Conversion Of Proline-u-lx' Into W O mentioning

confidence: 95%

Effects of Maternal Dietary Restriction on Hydroxyproline Levels in Urine and Tissues of the Young

Hsu

1973

Experimental Biology and Medicine

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Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

Cited by 22 publications

References 18 publications

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

Hydroxyproline excretion in various forms of growth failure.

Effects of Maternal Dietary Restriction on Hydroxyproline Levels in Urine and Tissues of the Young

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