Effect of titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) on the expression of mucin genes in human airway epithelial cells

Kim, Gui Ok; Choi, Yoon Seok; Bae, Chang Hoon; Song, Si-Youn; Kim, Yong‐Dae

doi:10.1080/08958378.2016.1267282

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…Recently, Kim et al reported an in vitro experiment regarding the expression of mucin genes in human airway epithelial cells. The authors confirmed that TiO 2 -NP initiated the TLR4-dependent pathway, leading to the MUC5B overproduction, which relates to the inflammatory response in human airway [37]. In Suarez-Lopez del Amo et al experiment, the TiO 2 particles derived following implantation were collected and co-cultured with the oral epithelial cells (NOK-SI).…”

Section: Resultsmentioning

confidence: 93%

General review of titanium toxicity

et al. 2019

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Background Titanium is a commonly used inert bio-implant material within the medical and dental fields. Although the use of titanium is thought to be safe with a high success rate, in some cases, there are rare reports of problems caused by titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. This comprehensive article has been prepared to review the toxicity of titanium materials within the medical and dental fields. Methods We used online searching tools including MEDLINE (PubMed), Embase, Cochrane Library, and Google Scholar by combining keywords such as “titanium implant toxicity,” “titanium implant corrosion,” “titanium implant allergy,” and “yellow nail syndrome.” Recently updated data has been collected and compiled into one of four categories: “the toxicity of titanium,” “the toxicity of titanium alloys,” “the toxicity of titanium implants,” and “diseases related to titanium.” Results Recent studies with regard to titanium toxicity have been increasing and have now expanded to the medical field in addition to the fields of environmental research and basic science. Problems that may arise in titanium-based dental implants include the generation of titanium and titanium alloy particles and ions deposited into surrounding tissues due to the corrosion and wear of implants, resulting in bone loss due to inflammatory reactions, which may lead to osseointegration failure of the dental implant. These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions. Zirconia implants can be considered as an alternative; however, limitations still exist due to a lack of long-term clinical data. Conclusions Clinicians should pay attention to the use of titanium dental implants and need to be aware of the problems that may arise from the use of titanium implants and should be able to diagnose them, in spite of very rare occurrence. Within the limitation of this study, it was suggested that we should be aware the rare problems of titanium toxicity.

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Section: Resultsmentioning

confidence: 93%

General review of titanium toxicity

et al. 2019

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“…The major macromolecular component of mucus is mucin. 9 Among the 14 human mucoid genes identified to date, mucin 5AC (MUC5AC) encodes the major mucin core protein secreted from the airway surface epithelium. 10 MUC5AC is highly expressed in the lung and its expression was up-regulated by various bacterial stimuli.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of azithromycin in airway diseases

Yang¹

2020

J Int Med Res

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Azithromycin (AZM) has been used to treat chronic inflammatory airway diseases because it regulates cell–cell contact between airway epithelial cells. Airway mucus hypersecretion is an important component of chronic respiratory diseases. Mucin 5AC (MUC5AC) is the major mucin produced by airway epithelial cells, and hypersecretion of MUC5AC is a sign of various pulmonary inflammatory diseases. Recently, it was found that matrix metallopeptidase 9 is involved in mucus hypersecretion. Moreover, AZM can inhibit the ability of TNF-α-to induce interleukin (IL)-8 production. This review focuses on the effects on AZM that may be beneficial in inhibiting MUC5AC, matrix metalloprotease-9 and IL-8 production in airway epithelial cells. In addition, recent studies have begun to assess activation of mitogen-activated protein kinase (MAPK) signaling pathways in response to AZM. Understanding these new developments may be helpful for clinicians.

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“…in vitro exposure of bronchial (E. Y. Chen et al, 2011;Kim et al, 2017) and colonic (Dorier et al, 2019) epithelial cell lines to TiO 2 NP stimulated an increase in mucus production. We found a similar increase following a single, high dose of oral TiO 2 NPs in our study.…”

Section: Discussionmentioning

confidence: 94%

“…Studies with human bronchial epithelial cells have shown an increase in mucus production in response to TiO 2 (E. Y. Chen et al, 2011;Kim, Choi, Bae, Song, & Kim, 2017); therefore, we predicted the expression of the main secreted mucin, muc2, would be affected by TiO 2 NP treatment. At 24 hours post-gavage, muc2 expression was lower in TiO 2 NP-treated animals compared with controls ( Figure 3).…”

Section: Mucin-2 Expression Elevated In Cecum Postexposurementioning

confidence: 99%

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

Kurtz

Mitchell

Nielsen

et al. 2020

J of Applied Toxicology

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Human exposure to a wide variety of engineered nanoparticles (NPs) is on the rise and use in common food additives increases gastrointestinal (GI) exposure. Host health is intricately linked to the GI microbiome and immune response. Perturbations in the microbiota can affect energy harvest, trigger inflammation and alter the mucosal barrier leading to various disease states such as obesity and inflammatory bowel diseases. We hypothesized that single high‐dose titanium dioxide (TiO2) NP exposure in mice would lead to dysbiosis and stimulate mucus production and local immune populations. Juvenile mice (9‐10 weeks) were gavaged with 1 g/kg TiO2 NPs and examined for changes in mucosa‐associated bacteria abundance, inflammatory cytokines, mucin expression and body mass. Our data provide support that TiO2 NP ingestion alters the GI microbiota and host defenses promoting metabolic disruption and subsequently weight gain in mice.

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Effect of titanium dioxide nanoparticles (TiO₂ NPs) on the expression of mucin genes in human airway epithelial cells

Abstract: These results demonstrate for the first time that TiO NPs induce MUC5B expression via TLR4-dependent ERK1/2 and p38 MAPK signaling pathways in respiratory epithelium.

Cited by 11 publications

References 25 publications

General review of titanium toxicity

General review of titanium toxicity

Mechanism of azithromycin in airway diseases

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

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Effect of titanium dioxide nanoparticles (TiO2 NPs) on the expression of mucin genes in human airway epithelial cells

Abstract: These results demonstrate for the first time that TiO NPs induce MUC5B expression via TLR4-dependent ERK1/2 and p38 MAPK signaling pathways in respiratory epithelium.

Cited by 11 publications

References 25 publications

General review of titanium toxicity

General review of titanium toxicity

Mechanism of azithromycin in airway diseases

Acute high‐dose titanium dioxide nanoparticle exposure alters gastrointestinal homeostasis in mice

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Product

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Effect of titanium dioxide nanoparticles (TiO₂ NPs) on the expression of mucin genes in human airway epithelial cells