Effect of Titanium Implants Coated with Radiation-Crosslinked Collagen on Stability and Osseointegration in Rat Tibia

Bae, Eun‐Bin; Yoo, Ji-Hyun; Jeong, So Young; Kim, Minsu; Lim, Youn-Mook; Ahn, Jong-Ju; Lee, Jin-Ju; Lee, So-Hyoun; Kim, Hyung‐Joon; Huh, Jung-Bo

doi:10.3390/ma11122520

Cited by 16 publications

(16 citation statements)

References 49 publications

(62 reference statements)

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“…In particular, the key protein for bone tissue formation, the osteocalcin was already produced and released to be bound to ECM for mineralization. Also, the vasculogenesis process was carried out by cell-Myth (Maipek Manufacturer Industrial Care, Naples, Italy) devices, even if in a later stage with respect to the control [45][46][47][48][49][50][51][52][53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study

Laino

Noce

Fiorillo

et al. 2021

BioMed Research International

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In the field of biology and medicine, one hears often about stem cells and their potential. The dental implant new surfaces, subjected to specific treatments, perform better and allow for quicker healing times and better clinical performance. The purpose of this study is to evaluate from a biological point of view the interaction and cytotoxicity between stem cells derived from dental pulp (DPSCs) and titanium surfaces. Through the creation of complex cells/implant, this study is aimed at analyzing the cytotoxicity of dental implant surfaces (Myth (Maipek Manufacturer Industrial Care, Naples, Italy)) and the adhesion capacity of cells on them and at considering the essential factors for implant healing such as osteoinduction and vasculogenesis. These parameters are pointed out through histology (3D cell culture), immunofluorescence, proliferation assays, scanning electron microscopy, and PCR investigations. The results of the dental implant surface and its interaction with the DPSCs are encouraging, obtaining results increasing the mineralization of the tissues. The knowledge of this type of interaction, highlighting its chemical and biological features, is certainly also an excellent starting point for the development of even more performing surfaces for having better healing in the oral surgical procedures related to dental implant positioning.

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Section: Discussionmentioning

confidence: 99%

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study

Laino

Noce

Fiorillo

et al. 2021

BioMed Research International

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“…Schliephake et al studied collagen-coated implants and demonstrated an increase in the percentage of BIC in a dog model [29]. Also, the study of Bae (2018) [30] in a rat tibia model showed an enhancement in the osseointegration and bone healing with collagen type I crosslinked by gamma irradiation. In this research we have not investigated what happens to the collagen during the phases of osseointegration; it is probably resorbed during the phases of bone healing.…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Surfaces Coated with Covalently Immobilized Collagen Type I: An X-Ray Photoelectron Spectroscopy, Atomic Force Microscopy, Micro-CT and Histomorphometrical Study in Rabbits

Lorusso

Orsini

Morra³

et al. 2019

IJMS

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Background: The process of osseointegration of dental implants is characterized by healing phenomena at the level of the interface between the surface and the bone. Implant surface modification has been introduced in order to increase the level of osseointegration. The purpose of this study is to evaluate the influence of biofunctional coatings for dental implants and the bone healing response in a rabbit model. The implant surface coated with collagen type I was analyzed through X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), micro-CT and histologically. Methods: The sandblasted and double acid etched surface coated with collagen type I, and uncoated sandblasted and double acid etched surface were evaluated by X-ray Photoelectron Spectroscopy (XPS) and Atomic Force Microscopy (AFM) analysis in order evaluate the different morphology. In vivo, a total of 36 implants were positioned in rabbit articular femoral knee-joint, 18 fixtures for each surface. Micro-CT scans, histological and histomorphometrical analysis were conducted at 15, 30 and 60 days. Results: A histological statistical differences were evident at 15, 30 and 60 days (p < 0.001). Both implant surfaces showed a close interaction with newly formed bone. Mature bone appeared in close contact with the surface of the fixture. The AFM outcome showed a similar roughness for both surfaces. Conclusion: However, the final results showed that a coating of collagen type I on the implant surface represents a promising procedure able to improve osseointegration, especially in regions with a low bone quality.

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“…In this case the turns of the dental implant with different dimensions, number and pitch may be affected. Coils may be present or not [30,31,32,33,34,35,36,37,38,39,40]. The function of the loops is to efficiently distribute the masticatory load and to guarantee stability in the early post-surgical phases of the implant [41,42,43].…”

Section: Methodsmentioning

confidence: 99%

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

et al. 2019

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The field of dental implantology has made progress in recent years, allowing safer and predictable oral rehabilitations. Surely the rehabilitation times have also been reduced, thanks to the advent of the new implant surfaces, which favour the osseointegration phases and allow the clinician to rehabilitate their patients earlier. To carry out this study, a search was conducted in the Pubmed, Embase and Elsevier databases; the articles initially obtained according to the keywords used numbered 283, and then subsequently reduced to 10 once the inclusion and exclusion criteria were applied. The review that has been carried out on this type of surface allows us to fully understand the features and above all to evaluate all the advantages or not related. The study materials also are supported by a manufacturing company, which provided all the indications regarding surface treatment and confocal microscopy scans. In conclusion, we can say that, thanks to these new surfaces, it has been possible to shorten the time necessary to obtain osseointegration and, therefore, secondary stability on the part of implants. The surfaces, therefore, guarantee an improved cellular adhesion and thanks to the excellent wettability all the biological processes that derive from it, such as increases in the exposed implant surface, resulting in an increase in bone-implant contact (BIC).

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Effect of Titanium Implants Coated with Radiation-Crosslinked Collagen on Stability and Osseointegration in Rat Tibia

Cited by 16 publications

References 49 publications

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study

Dental Pulp Stem Cells on Implant Surface: An In Vitro Study

Biomimetic Surfaces Coated with Covalently Immobilized Collagen Type I: An X-Ray Photoelectron Spectroscopy, Atomic Force Microscopy, Micro-CT and Histomorphometrical Study in Rabbits

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

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