Effect of topical bovine colostrum in wound healing of corneal surface after acute ocular alkali burn in mice

Tarff, Andreina; Drew-Bear, Laura E.; Meglio, Laura Di; Yee, Rebecca; Vizcaíno, M. Adelita; Gupta, Praveena; Annadanam, Anvesh; Cano, Marisol; Behrens, Ashley

doi:10.1016/j.exer.2022.109093

Cited by 10 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4A and B), showing grades V and VI of corneal injury. 23 Rapid corneal epithelium repair is important in avoiding secondary damage to the cornea, including infection. In this study, the corneal epithelium wounds healed slowly with PBS topical treatment, and obvious wounds remained after seven days of treatment.…”

Section: Resultsmentioning

confidence: 99%

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns

Zong-jian

Zhang

Wei³

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns

Zong-jian

Zhang

Wei³

et al. 2023

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…Following the TBUT test, the degree of corneal epithelial defect may be assessed under the crack lamp. 8 …”

Section: Methodsmentioning

confidence: 99%

“…By colouring the corneal fluorescence, this indicator may, therefore, assess the degree of the corneal epithelial defect. Following the TBUT test, the degree of corneal epithelial defect may be assessed under the crack lamp 8…”

Section: Methodsmentioning

confidence: 99%

Epidemiological features and management of eye burn patients in Wuxi, China

Chu

Yang

et al. 2023

BMJ Open Ophth

View full text Add to dashboard Cite

BackgroundThe current study aimed to analyse epidemiological data on eye burns in Wuxi, China, for the years 2015–2021, and to provide insight into the development of appropriate prevention strategies.MethodsA retrospective study was conducted on 151 hospitalised patients with eye burns. Data collected included gender, age, the monthly distribution of incidence, cause of eye burn, the site of eye burn, the type of surgery, visual outcome, the length of hospital stay and the cost of hospital admission. Statistical analysis was performed using SPSS V.19.0 and Graph Pad Prism V.9.0.ResultsIn a total of 151 eye burn patients, 130 were males (86.09%) and 21 were females (13.91%). The proportion of patients classified as grade III was the greatest (46.36%). The average age of our hospitalised patients with eye burns was 43.72 years and the average length of hospital stay was 17 days. The number of injuries was highest in September (14.6%). Among eye burn patients, workers and farmers became the most common occupations (62.91%, 12.58%). The most frequent cause of burns was alkali burns (19.21%), followed by acid burns (16.56%). When admitted to the hospital, patients’ average vision was 0.06, and 49% of them had a poor vision (<0.3, ≥0.05).ConclusionWith an investigation of 7-year hospitalisation data, the current study provided a fundamental reference for epidemiological features and management of eye burns in Wuxi, China, which could contribute to the development of treatment and prevention strategies.

show abstract

“…In our search, the in vitro studies found included studies in female guinea pigs 15 ; wistar albino rats 5 and female and male healthy C57BL/6 mice. 19 Doillon et al 15 treated wounds with a complex composite fraction of colostrum and compared two different models, one treated immediately and the other treated once closed. Results from the first model demonstrated that treatment with IMf (1:0.5 v/v ratio of IMf to cultura medium) for 23 days led to less wound contraction when compared to treatment with phosphate-buffered saline.…”

Section: In Vivomentioning

confidence: 99%

Exploring the potential of bovine colostrum as a bioactive agent in human tissue regeneration: A comprehensive analysis of mechanisms of action and challenges to be overcome

dos Santos,

Kraus,

da Silva Nascente

2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

The study examines bovine colostrum as a potent source of bioactive compounds, particularly growth factors, for tissue regeneration in humans. While previous research has hinted at therapeutic benefits, a comprehensive understanding of its mechanisms remains elusive, necessitating further investigation. This review analyzes nine selected scientific articles on bovine colostrum's bioactive potential in tissue regeneration. In vitro studies highlight its positive impact on cell behavior, including reduced proliferation and induced differentiation. Notably, optimal concentrations and specific colostrum components, such as extracellular vesicles and insoluble milk fat, show more favorable outcomes. In vivo studies underscore bovine colostrum as a promising natural resource for wound healing, despite some studies failing to identify associated benefits. Further research is crucial to unravel the intricate mechanisms, grasp the full potential in regenerative medicine, and develop more effective wound healing therapies. This refined understanding will pave the way for harnessing the complete regenerative potential of bovine colostrum in clinical applications.

show abstract

Effect of topical bovine colostrum in wound healing of corneal surface after acute ocular alkali burn in mice

Cited by 10 publications

References 47 publications

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro/in vivo experimental evaluation for the treatment of corneal alkali burns

Epidemiological features and management of eye burn patients in Wuxi, China

Exploring the potential of bovine colostrum as a bioactive agent in human tissue regeneration: A comprehensive analysis of mechanisms of action and challenges to be overcome

Contact Info

Product

Resources

About