Effect of topical clay application on the synthesis of collagen in skin: an experimental study

Valenti, D.; Silva, J.; Teodoro, W. R.; Velosa, Ana Paula Pereira; Mello, Suzana Beatriz Verissímo de

doi:10.1111/j.1365-2230.2011.04216.x

Cited by 20 publications

(11 citation statements)

References 14 publications

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“…Several substances have been tested to assess their contribution to delaying the skin aging process, by various mechanisms, such as scavenging of ROS and restoration of the redox balance (Hwang, 2010), inhibiting the expression or activity of MMP (Valenti et al, 2011), increasing the expression or regulation of tissue inhibitor of metalloproteinases (TIMP) (Landau, 2007), inhibition of elastosis (Langton et al, 2010), or simply by protecting against ultraviolet (UV) radiation that promotes the FIGURE 3 -Photomicrographs of skin stained with Masson's trichrome to observe collagen fibers (x100, details x400). (A) Female mouse skin from group 3 treated with vehicle and (B) female mouse skin from group 2 treated with L-arginine 10%.…”

Section: Discussionmentioning

confidence: 99%

The in vivo effect of L-arginine on skin elasticity in mice

Souza

Oliveira

Andrade

et al. 2017

Braz. J. Pharm. Sci.

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The human skin aging process is a complex mechanism that can be induced both by intrinsic and extrinsic factors. Observations include a decrease in the biosynthetic and proliferative capacity of cells, increased expression of matrix metalloproteinases, reduction in collagen type I expression, and the progressive disappearance of elastic tissue in the papillary dermis. L-arginine, the substrate of nitric oxide synthesis, is involved in angiogenesis and cell proliferation, as well as an indirect precursor of collagen synthesis via the proline pathway. The aim of this study was to examine the tensile strength, histology, and immunohistochemistry of female and male mice skin receiving different concentrations of topically applied L-arginine, in order to evaluate the possibility of using L-arginine as an active cosmetic ingredient in antiaging products. The results suggest that the application of L-arginine improves the mechanical resistance of skin from older female mice (20 weeks old) and promotes the formation of a larger amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.

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Section: Discussionmentioning

confidence: 99%

The in vivo effect of L-arginine on skin elasticity in mice

Souza

Oliveira

Andrade

et al. 2017

Braz. J. Pharm. Sci.

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“…Indeed, bentonite has been used for therapeutic purposes such as: curing wounds, relieving irritations, increasing collagen fibers, protecting skin against physical or chemical substances, and treating gastrointestinal disorders (López-Galindo and Viseras, 2004;Kevadiya et al, 2012;Valenti et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Bentonite protects neural crest stem cells from death caused by aflatoxin B1

Nones

Riella

Kuhnen

et al. 2015

Applied Clay Science

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“…Devido a estas propriedades, as bentonitas são utilizadas para reduzir efeitos colaterais provocados por diversos fármacos (Abbès et al, 2008;Kevadiya, 2012). Além disso, suas propriedades químicas auxiliam na cura de feridas, aliviam irritações, protegem a pele contra substâncias químicas ou físicas e auxiliam no tratamento de distúrbios gastrointestinais (López-Galindo e Viseras, 2004;Valenti et al, 2012).…”

Section: Introductionunclassified

Partículas Argilominerais Não Influenciam a Viabilidade Das Células-Tronco Da Crista Neural

Nones¹,

Riella²,

Kuhnen³

et al. 2015

Anais Do XX Congresso Brasileiro De Engenharia Química

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RESUMO -Partículas argilominerais apresentam inúmeras aplicações na indústria farmacêutica. Apesar de serem biotecnologicamente empregadas, seus efeitos sobre células-tronco da crista neural (CN) permanecem desconhecidos. Considerando estes aspectos, o objetivo deste trabalho foi caracterizar quimicamente partículas argilominerais (bentonita) extraídas da região Sul de Santa Catarina, assim como verificar sua influência sobre a viabilidade e sobrevivência das células-tronco da CN. Para tal, essas partículas argilominerais foram caracterizadas por difração de raios-X e ensaios físico-químicos. A viabilidade e morte das células foram determinadas por MTT e análise dos núcleos picnóticos, respectivamente. Nossos resultados demonstraram que partículas argilominerais (bentonita 0,6 mg/mL) não influenciam a viabilidade e a sobrevivência celular. Considerando as propriedades farmacológicas da bentonita, outros estudos deverão ser realizados com o intuito de avaliarmos seus efeitos em terapias envolvendo células-tronco.

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Effect of topical clay application on the synthesis of collagen in skin: an experimental study

Abstract: Clay application promotes an increase in the number of collagen fibres, which may account for its beneficial effects.

Cited by 20 publications

References 14 publications

The in vivo effect of L-arginine on skin elasticity in mice

The in vivo effect of L-arginine on skin elasticity in mice

Bentonite protects neural crest stem cells from death caused by aflatoxin B1

Partículas Argilominerais Não Influenciam a Viabilidade Das Células-Tronco Da Crista Neural

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