Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Gehring, W.; Gloor, M.

doi:10.1055/s-0031-1300268

Cited by 53 publications

(66 citation statements)

References 13 publications

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“…In another study, topical panthenol formulated in two different lipophilic vehicles was applied on the skin of healthy subjects. Twice-daily application over seven days significantly improved SC hydration compared with controls (11). In a randomized, intra-individual comparison in AD patients, topical application of a moisturizer containing a ceramide precursor resulted in significantly increased skin hydration in the treated skin area compared with untreated skin.…”

Section: Dryness Body Facementioning

confidence: 81%

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A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Stettler

Wagner³

et al. 2016

Journal of Dermatological Treatment

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Purpose: Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants. Methods: In Study 1 (N ¼ 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N ¼ 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N ¼ 21). Results: In Study 1, mean AUC 0 À 24 h for skin capacitance change from baseline was 302.03 i.u. with NTP-CE and À15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (À45.10 vs. À13.39 g/cm 2 , p ¼ .013) and the water gradient increased (0.51 vs. 0.11 g/ cm 4 , p ¼ .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001). Conclusions: Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants. ARTICLE HISTORY

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Section: Dryness Body Facementioning

confidence: 81%

“…For the same reason, no primary and secondary variables were defined. Based on historical data, it was expected that scientifically meaningful results can be obtained with the selected sample size (11)(12)(13)(14).…”

Section: Study 1: Moisturization Studymentioning

confidence: 99%

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Stettler

Wagner³

et al. 2016

Journal of Dermatological Treatment

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Section: Methodsmentioning

confidence: 99%

“…Apart from the well-known panthenol (8), it contains glycerin, different lipids (e.g. ceramide 3), vitamin B 3 which is known to increase skin lipid production (9), and the prebiotic a-glucan oligosaccharide as key elements.…”

Section: Introductionmentioning

confidence: 99%

A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

Stettler

Lunau³

et al. 2016

Journal of Dermatological Treatment

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(2017) A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora, Journal of Dermatological Treatment, 28:2, 173-180, DOI: 10.1080/09546634.2016 Purpose: Two randomized, intra-individual comparison studies were performed in healthy subjects to evaluate the skin moisturization and barrier restoration potential of a new topical panthenol-containing emollient (NTP-CE) (Study 1), and its effect on skin microflora (Study 2). Methods: In Study 1 (N ¼ 23), two skin areas, one challenged with 0.5% sodium dodecyl sulfate (SDS) solution and one unchallenged, were treated with NTP-CE for 3 weeks. Transepidermal water loss (TEWL), skin hydration, and intercellular lipid lamellae (ICLL) organization were measured at regular intervals during the study. In Study 2 (N ¼ 20), quantitative bacterial cultures were obtained over 6 h from a skin area undergoing wash stress with 10% SDS with subsequent single application of NTP-CE. Results: In Study 1, mean AUC for TEWL reduction from baseline was more pronounced with NTP-CE compared with control (À168.36 vs. À123.38 g/m 2 /h, p ¼ 0.023). NTP-CE use was also associated with statistically significant improvements in stratum corneum hydration and an increase in mean ICLL length from baseline (day 22: 120.61 vs. 35.85 nm/1000 nm 2 , p < 0.001). In Study 2, NTP-CE use had no negative impact on bacterial viability. Conclusions: NTP-CE use has favorable and lasting effects on barrier function and repair as well as skin hydration without negatively influencing bacterial viability. ARTICLE HISTORY

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“…В доступных лите-ратурных источниках случаи гипервитаминоза не описа-ны [26]. Эффективность и безопасность средств, содер-жащих декспантенол, подтверждена в многочисленных клинических исследованиях [27][28][29][30]. Так, в частности, G. Putet и соавт.…”

Section: профилактика пеленочного дерматитаunclassified

Peculiarities of the Course and Prevention of Diaper Dermatitis in Newborns and Infants

Николаевич¹,

Материкин²,

Епишев³

et al. 2016

Vopr. sovr. pediatr.

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Effect of Topically Applied Dexpanthenol on Epidermal Barrier Function and Stratum Corneum Hydration

Cited by 53 publications

References 13 publications

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

Peculiarities of the Course and Prevention of Diaper Dermatitis in Newborns and Infants

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