Effect of Total-Body Irradiation on the Response of Transplanted Mouse Tumors to Fractionated Local Radiotherapy

Sikov, M.R.; Cook, Bettina B.; Lofstrom, James E.

doi:10.1148/81.4.642

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…A wide spectrum of transplanted tumour systems has been tested by Sikov and Lofstrom (1961) and Sikov, Cook and Lofstrom (1963), confirming and extending Hollcroft's original work. These studies have shown an increase in cure-rates and prolongation of survival-time of mice bearing Lymphosarcoma-1 when treated with combinations of local and whole-body radiation.…”

Section: Introductionsupporting

confidence: 73%

Absence of the Synergistic Effect of Whole-body Irradiation and Local Tumour Irradiation in an Autochthonous Lymphoid Tumour System

Hanks

Kaplan

1964

International Journal of Radiation Biology and Related Studies

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Section: Introductionsupporting

confidence: 73%

Absence of the Synergistic Effect of Whole-body Irradiation and Local Tumour Irradiation in an Autochthonous Lymphoid Tumour System

Hanks

Kaplan

1964

International Journal of Radiation Biology and Related Studies

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“…T h e tumor growth rate of the animals of group I11 shows a marked reduction in weeks 2 to 12 when compared with controls CANCER July 1970 Vol. 26 and a reduction in weeks 2 to 16 when com-Effects of triple leukophoresis post-tumor pared with single-treated animals. Again, injection: T h e 20 animals leukophoresed a this reduction was especially pronounced in third time after tumor injection have a mean animals treated between 1 and 4 weeks after survival time of 286 days post-injection comtumor injection (Table 3, Fig.…”

Section: Single Leukophoresis After Tumor Injectionmentioning

confidence: 97%

“…Total body and regional lymphatics: Sikov et a1. 26.28 have shown that small doses of whole body radiation therapy (which produce leukopenia) could enhance the oncolytic effect of local irradiation on a variety of transplantable mouse tumors. This work was based on earlier experiments of Holcroft and Matthewsl4 and Edelmann.12 This oncolytic effect might be mediated by some circulating toxic substance produced by whole body irradiation.…”

mentioning

confidence: 99%

Effect of leukopenia and leukocytosis on tumor growth and survival time.Part I. Leukopenia

Scott

Matthews

Henrick

1970

Cancer

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The study was performed with 174 rabbits to determine the effect of leukophoresis and the resulting leukopenia on tumor transplant, growth, and survival time using the V2 carcinoma in the rabbit. Definite inhibition of tumor growth, together with increase in survival time, was found when leukophoresis was performed 7‐28 days after transplant as evidenced by an increase in survival time of 314 days in the entire group receiving 2 leukophoreses following transplants and 347 days in subgroups of those receiving 3 leukophoreses following transplants (but on days 7‐14‐21 or 14‐21‐28) vs. 73 days for the controls. The tumor growth rate paralleled the survival time and following transplant and leukophoresis, the increase and decrease of leukocytes paralleled the rate of tumor growth and retardation, respectively. There is reason to believe that the granulocyte may be more implicated than lymphocyte in tumor inhibition and survival time although so far experimental evidence has been on the side of the latter. A chance observation that leukophoretic plasma injected into cancerous and noncancerous animals produced marked leukocytosis, indicating a leukocytosis‐inducing factor, will serve to investigate any significant effects of leukocytosis on tumor growth and survival time and any possible interrelationship of leukopenia/leukocytosis to tumor inhibition and immunosuppression in Part II of this paper.

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“…This study concerns itself with the demonstration of a leukocytosis-inducing factor in the leukopenic plasma of both normal and cancerous rabbits and VOl. 26 its effect upon tumor growth and survival. Plasma from sham leukophoresed rabbits was used as a nonleukopenic control to eliminate the possibility of a contaminant causing leukoc ytosis.…”

mentioning

confidence: 99%

Effect of leukopenia and leukocytosis on tumor growth and survival time.Part II. Leukocytosis

Scott

Matthews

Henrick

1970

Cancer

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Experiments with the effects of leukocytosis on tumor growth and animal survival time using the V‐2 carcinoma transplant in the rabbit failed to show any effect of the leukocytosis per se. However, the present study exploring the Leukocytosis‐Inducing Factor (LIF) isolated in leukophoresed plasma found it to be present in the plasma of cancerous rabbits and present to a greater extent in the leukopenic plasma of normal leukophoresed animals. The target cell of the LIF appears to be neutrophil‐forming tissue with production of neutrophilic band cells and metamyelocytes. The optimal injection volume and time interval following leukophoresis‐leukopenia for achieving maximum leukocytosis suggest a “time‐dose” relationship. There was a marked absolute increase in leukocyte response of the cancerous recipients over noncancerous recipients following the injection of cancerous and noncancerous leukopenic plasma as well as both relative and absolute increase with the injection of the former over the latter into both recipients. The interrelationship of chemotherapy, radiation, and leukophoresis is discussed in reference to their common denominator of leukopenia and consequent tumor suppression, immunosuppression, and LIF production which are probably motivated by the Host Resistance Factor (HRF).

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Effect of Total-Body Irradiation on the Response of Transplanted Mouse Tumors to Fractionated Local Radiotherapy

Cited by 4 publications

References 8 publications

Absence of the Synergistic Effect of Whole-body Irradiation and Local Tumour Irradiation in an Autochthonous Lymphoid Tumour System

Absence of the Synergistic Effect of Whole-body Irradiation and Local Tumour Irradiation in an Autochthonous Lymphoid Tumour System

Effect of leukopenia and leukocytosis on tumor growth and survival time.Part I. Leukopenia

Effect of leukopenia and leukocytosis on tumor growth and survival time.Part II. Leukocytosis

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