2021
DOI: 10.12965/jer.2142618.309
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Effect of treadmill exercise combined with bone marrow stromal cell transplantation on atrophy-related signaling pathway in the denervated soleus muscle

Abstract: The purpose of this study was to investigate whether combination of low-intensity exercise with bone marrow stromal cell (BMSC) transplantation could regulate protein kinas B (Akt)- mammalian target of rapamycin (mTOR) and Wnt3a-β-catenin signaling pathways for prevention of soleus muscle atrophy after sciatic nerve injury (SNI). The experimental rats divided into 5 groups (n= 10): normal control group, SNI+sedentary group (SED), SNI+low-intensity treadmill exercise group (TEX), SNI+BMSC transplantation group … Show more

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Cited by 3 publications
(5 citation statements)
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“…# P< 0.05, ## P< 0.01 vs. SED group. mTOR and MRF signaling networks has been known as a specific regulator to prevent atrophy in the denervated muscles (Brooks and Myburgh, 2014), and these mechanisms is stimulated by anaerobic exercise and cell transplantation approaches applied during denervation period (Chen et al, 2022;Cho and Seo, 2021). Proteins-regulated kinase Akt is upstream protein to lead to activation of mTOR signaling pathway, whose downstream substrate including p70S6K not only promote protein synthesis but also inhibit muscle atrophy (Yin et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
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“…# P< 0.05, ## P< 0.01 vs. SED group. mTOR and MRF signaling networks has been known as a specific regulator to prevent atrophy in the denervated muscles (Brooks and Myburgh, 2014), and these mechanisms is stimulated by anaerobic exercise and cell transplantation approaches applied during denervation period (Chen et al, 2022;Cho and Seo, 2021). Proteins-regulated kinase Akt is upstream protein to lead to activation of mTOR signaling pathway, whose downstream substrate including p70S6K not only promote protein synthesis but also inhibit muscle atrophy (Yin et al, 2020).…”
Section: Discussionmentioning
confidence: 99%
“…As described in study by Cho and Seo (2021), bone marrow tissues were collected by perfusion through femur and tibia of 4-weekold SD rats with the culture medium and they were cultured in Dulbecco's modified Eagle's medium with 20% fetal calf serum. Five to 7 days later, BMSCs adhered to the base on the culture dishes proliferated to a density of ca.…”
Section: Bmsc Culturementioning
confidence: 99%
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“…Rats in the injury groups were anesthetized with using an animal inhalation narcosis control (Jeungdo Bio & Plant, Seoul, Korea). Following the surgical procedure reported in Cho's study (Cho and Seo, 2021), all rats were placed into the chamber with 2%-2.5% concentration of isoflurane for anesthesia and then 1.5%-1.8% concentration for maintenance during SNI. The left sciatic nerve was crushed with a pair of forceps held tightly for 1 min and 30 sec at intervals (Seo et al, 2021).…”
Section: Sciatic Nerve Injurymentioning
confidence: 99%
“…As suggested in Cho's study (Cho and Seo, 2021), the femur and tibia of 4-week-old SD rats were dissected, and bone marrow tissue was extracted using Dulbecco's modified Eagle's medium (DMEM) medium. Extracted bone marrow tissue were cultured in DMEM medium with 20% fetal calf serum.…”
Section: Bmsc Culture and Transplantationmentioning
confidence: 99%