Effect of Tribulus Terrestris on Learning and Memory in Wistar Rats

Prabhu, Natesh M; Hadigal, Sanjay; D, Ullal Sheetal; Ds, Sushma; Shenoy, Nandita

doi:10.5530/pj.2014.4.10

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…The effect of the water extract of TT fruits on learning and memory ability in rodents was evaluated by recording the time of reaching the reward chamber (TRC) in the Hebb William Maze and the transfer latency (TL) in the T-zema. The results showed that the water extract of TT fruits significantly reduced the time of arrival at the maze in a dose-dependent manner [ 108 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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“…TT extracts have therapeutical potential for the recovery of normal skin barriers. 227 Ghareeb et al 228 examined extracts of Calluna vulgaris, Ferula hermonis, and TT and found that the activity depended on the concentration of antiacetylcholinesterase. The 3 extracts showed antioxidant function as they inhibited 1,1-diphenyl-2-picryl hydrazyl oxidation and production of thiobarbituric acid reactive substances.…”

Section: Other Pharmacological Uses Of T Terrestrismentioning

confidence: 99%

“…El-Tantawy and Hassanin 212 found that TT saponins revitalized β-cells of pancreatic islets. Nam et al 227 reported the modulatory effect of TT fruits on atopic dermatitis through modulating the activities of calcium ion channels, Orai1 and TRPV3. TT extracts have therapeutical potential for the recovery of normal skin barriers.…”

Section: Other Pharmacological Uses Of T Terrestrismentioning

confidence: 99%

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

Semerdjieva

Zheljazkov

2019

Natural Product Communications

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Tribulus terrestris L. (TT) (puncturevine) is a common weed that grows in many countries worldwide and in some places is considered as a noxious weed. The plant has been used in traditional Chinese and Indian medicines and is now considered as one of the most popular aphrodisiacs. It is known for its healing properties for sexual difficulties, impotence, and human and animal hormonal imbalance. It is also used as a sexual booster. Because of the plant’s active substances that can be used for curing sexual and other disorders, interest in it is increasing, and it is currently one of the most studied medicinal plants. The products and preparations manufactured from the aboveground plant parts are especially popular among athletes and people with health issues and diseases such as hormonal imbalance, sexual problems, heart problems, and various kidney and skin diseases. The aim of this review is a comprehensive and critical assessment of the scientific publications involving TT, with special reference to its chemical constituents and biological properties that may facilitate current understanding and future studies of this fascinating plant species. The objectives of this review were (1) to find knowledge gaps, (2) to discuss critically relevant publications and issues with materials and methods that may be prerequisites for contradictory results, and (3) to identify research and development areas. It was found that some of the studies on TT extracts as aphrodisiacs are controversial. A significant number of research publications claim that TT extracts and nutritional supplements containing TT improve muscle tone, have a common biostimulating effect, and improve spermogenesis. However, there are a growing number of publications that dispute these claims, as there are no empirical data on commonly accepted mechanisms of action. The main biologically active substances in TT are steroidal saponins, flavonoids, alkaloids, and lignan amides, the most studied being the steroidal saponins. Multiyear data on the metabolic profile of the species are generally lacking. There are a variety of methods used for extracting plant material, differences in methodologies and saponin analyses, and scientific instruments that were used. Lack of common standards could be a reason for differences in the pharmacological activity and composition of the TT preparations. Development of standard procedures and methods for collection of plant material and analyses are recommended. Selection and breeding efforts and agronomic studies of promising clones of TT would need to be conducted in order to develop TT as a new crop. This will provide consistency of supply and quality of the feedstock for the pharmaceutical industry and could provide a new cash crop for growers.

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“…Fructus Tribuli (FT), which is the dried fruit of Tribulus terrestris L. [ 7 ], is renowned in TCM as Ji-Li and has been used for thousands of years in Asian countries. Several previous investigations focused on its pharmacological activities demonstrated that FT improved sexual function [ 8 ], could be used to prevent and treat cardiovascular diseases [ 9 ], had neuroprotective [ 10 ] and memory improvement activity [ 11 ], and provided antidiabetic [ 12 ], antidepression [ 13 ], anti-inflammatory [ 14 ], and antioxidant effects [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the Potential Mechanism of Fructus Tribuli in the Treatment of Hypertensive Vascular Remodeling Based on Network Pharmacology and Molecular Docking

Wang

Guo

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Hypertensive vascular remodeling (HVR) is the pathophysiological basis of hypertension, which is also an important cause of vascular disease and target organ damage. Treatment with Fructus Tribuli (FT), a traditional Chinese medicine, has a positive effect on HVR. However, the pharmacological mechanisms of FT are still unclear. Therefore, this study aimed to reveal the potential mechanisms involved in the effects of FT on HVR based on network pharmacology and molecular docking. Materials and Methods. We selected the active compounds and targets of FT according to the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the Swiss Target Prediction database, and the targets of HVR were collected from the Online Mendelian Inheritance in Man (OMIM), GeneCards, and DrugBank databases. The protein-protein interaction network (PPI) was established using the STRING database. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses and network analysis were performed to further explore the potential mechanisms. Finally, molecular docking methods were used to evaluate the affinity between the active compounds and the main target. Results. Seventeen active compounds of FT and 164 potential targets for the treatment of HVR were identified. Component-target and PPI networks were constructed, and 12 main active components and 33 main targets were identified by analyzing the topological parameters. Additionally, GO analysis indicated that the potential targets were enriched in 483 biological processes, 52 cellular components, and 110 molecular functions. KEGG analysis revealed that the potential targets were correlated with 122 pathways, such as the HIF-1 signaling pathway, ErbB signaling pathway, and VEGF signaling pathway. Finally, molecular docking showed that the 12 main active components had a good affinity for the top five main targets. Conclusion. This study demonstrated the multiple compounds, targets, and pathway characteristics of FT in the treatment of HVR. The network pharmacology method provided a novel research approach to analyze potential mechanisms.

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Effect of Tribulus Terrestris on Learning and Memory in Wistar Rats

Cited by 11 publications

References 8 publications

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Chemical Constituents, Biological Properties, and Uses of Tribulus terrestris: A Review

Study on the Potential Mechanism of Fructus Tribuli in the Treatment of Hypertensive Vascular Remodeling Based on Network Pharmacology and Molecular Docking

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