Effect of two different doses of dexmedetomidine on the hemodynamics of “Hypertensive Patients” undergoing laparoscopic cholecystectomy

Prakash, Ved; Mishra, Neelkamal; Prakash, Ravi; Kumar, Sanjeev; Jafa, Shobhna

doi:10.4103/aer.aer_14_21

Cited by 2 publications

(2 citation statements)

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“…Dexmedetomidine [3,4,[11][12][13] is a highly selective alpha-2 receptor agonist that can stimulate alpha-2 receptors located in the locus coeruleus and spinal cord. It exerts both sedative and analgesic effects.…”

Section: Discussionmentioning

confidence: 99%

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Sedative Effects of Dexmedetomidine in Combination with Propofol in Patients with Atrial Fibrillation Undergoing Electrical Cardioversion following Catheter Ablation

Liu,

Peng,

et al. 2024

Preprint

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Background To observe the safety and effectiveness of sedation in patients with atrial fibrillation (AF) undergoing electrical cardioversion following catheter ablation using a combination of propofol and dexmedetomidine (P-D group) versus propofol alone (P group). Methods A total of 120 AF patients undergoing electrical cardioversion post-catheter ablation were enrolled from October 2020 to August 2022. They were randomly assigned to either the observation group (P-D group) or the control group (P group), with 60 patients in each group. Vital signs, adverse events, analgesic effects, and awakening time were assessed at different stages (T0-T4) in both groups. Results In P-D group, HR was lower than T0 in T1-4, the MAP and SpO2 began to decreased in T2-3.In P group, SpO2, HR and MAP in T2-4 were all inferior to baseline period of T0. Whereas, in P-D group, the descend range of MAP and SpO2 of T2, and the SpO2 of T3 were distinctly less than the P group. The adverse events including respiratory depression and bradycardia in P-D group were inferior to the P group (16.7% vs 40% P = 0.045; 13.3% vs 3.3%; P = 0.35). The satisfaction of analgesia in P-D group was apparently prominent than P group (93.3% vs 73.3%;P < 0.05). Conclusion In AF patients requiring electrical cardioversion, the combination of propofol and dexmedetomidine demonstrates good sedative and analgesic effects, significantly reducing the propofol dosage and lowering the incidence of clinical adverse events, thereby enhancing medication safety.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, when combined with other sedative or analgesic agents, dexmedetomidine can reduce the required dosage of the corresponding drugs and attenuate surgical stress responses [12,13] . This has led to its use as an adjuvant in anesthesia and analgesia, as well as in sedation during various clinical procedures.…”

Section: Discussionmentioning

confidence: 99%