Effect of Two Different Therapeutic Approaches on Total and Cardiovascular Mortality in a Cardiovascular Study in the Elderly (CASTEL).

Casíglia, Edoardo; Spolaore, Paolo; Mazza, Alberto; Ginocchio, Giuliana; Colangeli, Giovanna; Onesto, Caterina; Menza, Giuseppe di; Pegoraro, Lorenza; Ambrosio, Giovanni B.

doi:10.1536/ihj.35.589

Cited by 69 publications

(37 citation statements)

References 17 publications

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“…Our meta-regression analysis (6) involved 30 trials including 149,407 randomized patients: 9 actively controlled trials (MIDAS (8), CAPPP (9,73), NICS (10), STOP2 (11), INSIGHT (12,74), NORDIL (13), ALLHAT/ Dox (14), VHAS (26), and UKPDS (16,75)); the HOT trial (76), which investigated 3 levels of diastolic blood pressure (96)). Seven studies were excluded for the following reasons: fewer than 100 patients had been randomized (97−99), follow-up was less than 2 years (100, 101), insufficient information was published on achieved SBP (HDFP (102, 103)) or non-fatal outcomes (CASTEL (104)), and/or randomization took place between usual and referred care (CASTEL (104) and HDFP (102,103)). …”

Section: Role Of Blood Pressure Reductionmentioning

confidence: 99%

Blood Pressure Reduction and Cardiovascular Prevention: An Update Including the 2003-2004 Secondary Prevention Trials

et al. 2005

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Section: Role Of Blood Pressure Reductionmentioning

confidence: 99%

Blood Pressure Reduction and Cardiovascular Prevention: An Update Including the 2003-2004 Secondary Prevention Trials

et al. 2005

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“…The CAS-TEL, which was started 14 years ago, has been used up to this time to demonstrate the feasibility of a longitudinal prospective study based on an elderly general population, 15 to define the role of cardiovascular risk factors in the elderly, [16][17][18][19] and to analyse the effects of special care on cardiovascular survival. 20,21 The study lasted 14 years and was carried out in accordance with the Declaration of Helsinki and approved by the CASTEL Ethics Committee. The procedures followed were in accordance with institutional guidelines.…”

Section: Study Populationmentioning

confidence: 99%

Pulse pressure and coronary mortality in elderly men and women from general population

et al. 2002

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The aim of this work was to evaluate whether pulse pressure (PP) in elderly people is a better predictor of coronary mortality than systolic and diastolic blood pressure taken alone. For this aim, 3282 elderly subjects aged у65 years were studied in a population-based frame. Blood pressure was repeatedly measured and averaged; historical data, anthropometrics, blood tests and 14-year coronary mortality were recorded. Statistics included analysis of covariance, Cox analysis and bivariate vectorial analysis. Coronary mortality in women was predicted by PP (1.01 excess risk/mm Hg PP) and was significantly higher in the 3rd than in the 1st tertile of PP (relative risk 2.90); neither systolic nor diastolic pressure taken alone influenced mortality. When systolic and diastolic pressures were both entered into a Cox model, the former had a positive and

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“…As previously described elsewhere, 19 655 subjects -screened from the general population in the frame of a clinical trial-were randomly assigned to special care (decided and conducted by a hypertension unit) or to free therapy (decided and conducted by general practitioners). The two groups differed in that, those belonging to the hypertension unit underwent assiduous BP control, advice concerning lifestyle and answers to any questions concerning personal health problems, while those pertaining the free therapy were followed by their physician who spontaneously prescribed a treatment and were simply observed during the following 14 years by the CASTEL task force.…”

Section: Definitionsmentioning

confidence: 99%

Weak effect of hypertension and other classic risk factors in the elderly who have already paid their toll

et al. 2002

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The aim of the CASTEL, a population-based (n ‫؍‬ 3282) prospective study which began 14 years ago, was to identify those items which had a prognostic impact in the elderly, and to evaluate whether the typical cardiovascular risk factors, particularly arterial hypertension, play a role after the age of 65 years. Initial screening, final follow-up and annual detection of mortality were performed. Mantel-Hanszel approach and multivariate Cox model were used for statistics. Cardiovascular mortality was 23.3% in normotensive, 23.3% in borderline, and 25% in the sustained hypertensive subjects (insignificant difference). In women, the incidence of stroke and coronary artery disease weakly depended on pulse pressure. Historical stroke and myocardial infarction predicted cardiovascular mortality in women; diabetes, uricaemia and high heart rate in men. In the very old, the predictors were less numerous, and blood pressure was not a predictor whatsoever; pulse blood

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Effect of Two Different Therapeutic Approaches on Total and Cardiovascular Mortality in a Cardiovascular Study in the Elderly (CASTEL).

Cited by 69 publications

References 17 publications

Blood Pressure Reduction and Cardiovascular Prevention: An Update Including the 2003-2004 Secondary Prevention Trials

Blood Pressure Reduction and Cardiovascular Prevention: An Update Including the 2003-2004 Secondary Prevention Trials

Pulse pressure and coronary mortality in elderly men and women from general population

Weak effect of hypertension and other classic risk factors in the elderly who have already paid their toll

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