Effect of type and extent of crystalline order on chemical and physical stability of carbamazepine

In Vitro Performance of Carbamazepine Loaded to Various Molecular Weights of Poly (D, L-Lactide-Co-Glycolide)

“…This attribute of polymorph II is in agreement with Rustichelli et al 2000 andNaima et al 2001. There is consensus in the literature that CBZ crystallizes to three forms, at least: a trigonal (form II), a monoclinic (form III), and a high-temperature phase (form I) (Krahn and Mielck 1989).…”

Improving the Chemical Stability of Amorphous Solid Dispersion with Cocrystal Technique by Hot Melt Extrusion

“…Most of the cocrystals showed much lower melting points than T m of CBZ form I (190°C). As a heat-sensitive drug, there are many reports focused on its decomposition at high temperature (17,18).…”

Influence of Polymorphic Form, Morphology, and Excipient Interactions on the Dissolution of Carbamazepine Compacts

“…[4][5][6][7] In the past 20 years, investigations of CBZ have focused on the in vitro dissolution behavior and in vivo bioavailability of the drug where dissolution tests were employed in most studies. 5,[8][9][10][11][12][13][14] It was found that different CBZ forms have different physico-chemical properties 7,[15][16][17] and dissolution profiles with CBZ dihydrate (DH) showing the slowest dissolution rate and solubility (approximately two thirds of that of CBZ form III). 4 Also, dissolution testing of different sources of marketed CBZ tablets stored at varying temperature and humidity conditions has been carried out.…”