Effect of ursocholic acid on bile lipid secretion and composition

Loria, Paola; Carulli, Nicola; Medici, Giuseppe; Menozzi, D; Salvioli, Gianfranco; Bertolotti, Marco; Montanari, Mirella

doi:10.1016/0016-5085(86)90862-0

Cited by 34 publications

(15 citation statements)

References 36 publications

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“…This observation is consistent with the finding of Carulli et al [25] and Loria et al [26] that biliary secretion of alkaline phosphatase, a bile canalicular membrane constituent, is proportional to the detergent capacity of the administered bile acid in man.…”

Section: Biliary Lipid Couplingsupporting

confidence: 93%

“…A close association between bile acid and cholesterol and between bile acid and phospholipid secretion has been reported in all animal species studied [ 1 -171, irrespective of methodology. Convincing evidence for this association has been provided in man both from acute depletion of the bile acid pool via a T-tube and from duodenal reinfusion of bile acid in cholecystectomized patients [18][19][20][21][22][23][24][25][26], as well as from acute bile acid pool depletion-repletion studies carried out in healthy subjects utilizing an occludable naso-duodenal tube for bile drainage [27]. Qualitatively similar results have also been reported in man with an intact enterohepatic circulation of bile acids using duodenal perfusion techniques.…”

Section: Biliary Lipid Couplingmentioning

confidence: 99%

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Biliary lipid secretion in man

Lanzini

Northfield

1991

Eur J Clin Investigation

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Section: Biliary Lipid Couplingsupporting

confidence: 93%

Section: Biliary Lipid Couplingmentioning

confidence: 99%

Biliary lipid secretion in man

Lanzini

Northfield

1991

Eur J Clin Investigation

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“…Together with the regulatory role of the physical–chemical properties of the recirculating bile acid pool,30 it has been postulated that opposing changes of cholesterol production and degradation might increase biliary cholesterol saturation and predispose to stone formation,14 even if this was not confirmed by enzyme activity analysis in the liver tissue 15. Further, more recent evidence has demonstrated an increase, rather than a decrement, in metabolic markers of bile acid synthesis 31,32.…”

Section: Discussionmentioning

confidence: 99%

Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population

Bertolotti¹,

Mussi²,

Pellegrini³

et al. 2014

CIA

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BackgroundThe modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols.MethodsWe analyzed serum samples collected from 201 adult (75 male, 126 female) subjects within the epidemiological MICOL study (Multicentrica Italiana Colelitiasi). The age range was 38–79 years; 103 had evidence of gallstones. The concentrations of the different sterols, recognized as markers of the main pathways of cholesterol homeostasis, were analyzed by gas chromatography-mass spectrometry, including lathosterol (synthesis), campesterol and sitosterol (absorption), and 7α-hydroxy-4-cholesten-3-one (degradation to bile acids).ResultsA significant direct correlation was detected between age and cholesterol levels (r =0.34, P<0.01). The lathosterol/cholesterol ratio was lower in older age quartiles (P<0.05 by analysis of variance), with an inverse correlation between the lathosterol/cholesterol ratio and age (r=−0.32, P<0.01). Such correlation was particularly evident in females. The campesterol/cholesterol and sitosterol/cholesterol ratios were inversely correlated with aging in control, but not in gallstone patients. The levels of 7α-hydroxy-4-cholesten-3-one were not correlated with age.ConclusionThese data show a reduction of cholesterol synthesis with aging which is associated with increased circulating cholesterol levels. The finding might be related to a reduced metabolic need for cholesterol in advancing age, leading to a downregulation of the main mechanisms of cholesterol intake in the liver. A different age-related behavior was observed in gallstone-free versus gallstone patients regarding cholesterol absorption. The possible implications in terms of the pharmacological management of hypercholesterolemia in the elderly remain to be defined.

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“…Canalicular bile flow depends not only on the amount of bile acids secreted, but also on bile acid composition [24]. If "more hydrophobic" bile acids (CDCA and DCA) are found in a higher concentration in bile than in "less hydrophobic" bile acids (CA), then greater bile flow is expected [25]. Therefore, it is possible that despite an increased TBA output rate, the flow was proportionally reduced in "sub-optimal" grafts because of differences in bile acid composition, particularly increased CA levels.…”

Section: Discussionmentioning

confidence: 99%

Bile acids analysis: a tool to assess graft function in human liver transplantation

et al. 2004

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The expanding use of “sub‐optimal” grafts due to donor organ shortage increases the importance of accurate graft assessment before liver transplantation. Bile secretion is an early sign of recovering hepatic function post‐transplant. The role of bile acid analysis in assessing graft function before and immediately after liver transplantation has been investigated. Two hundred and sixteen samples of hepatic bile were collected from 35 donors and 13 recipients. Clinical data, bile flow, total bile acid concentration, apparent choleretic activity and bile acid composition were assessed. Sub‐optimal donor livers showed a low apparent choleretic activity and a different bile acid composition when compared to normal grafts. In recipients, the pattern of recovery of bile secretion immediately after reperfusion was a useful predictor of graft function. This study characterises bile acid secretion of liver grafts and remarks the potential value of bile acid analysis to assess donor liver quality and early post‐transplant graft function.

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Effect of ursocholic acid on bile lipid secretion and composition

Cited by 34 publications

References 36 publications

Biliary lipid secretion in man

Biliary lipid secretion in man

Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population

Bile acids analysis: a tool to assess graft function in human liver transplantation

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