Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

Wang, Chong; Zhou, Xijin; Li, Yuanyuan; Wan, Juan; Yang, Le-ying; Li, Guohua

doi:10.1155/2013/429545

Cited by 6 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly, we hypothesized that phytoncides are able to stimulate the olfactory epithelium and regulate hormones. Among these hormones, vasoactive intestinal peptide (VIP) is known to be able to control NK cell activation [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Cha

Kim

et al. 2021

IJMS

View full text Add to dashboard Cite

Natural killer (NK) cells are lymphocytes that can directly destroy cancer cells. When NK cells are activated, CD56 and CD107a markers are able to recognize cancer cells and release perforin and granzyme B proteins that induce apoptosis in the targeted cells. In this study, we focused on the role of phytoncides in activating NK cells and promoting anticancer effects. We tested the effects of several phytoncide compounds on NK-92mi cells and demonstrated that α-pinene treatment exhibited higher anticancer effects, as observed by the increased levels of perforin, granzyme B, CD56 and CD107a. Furthermore, α-pinene treatment in NK-92mi cells increased NK cell cytotoxicity in two different cell lines, and immunoblot assays revealed that the ERK/AKT pathway is involved in NK cell cytotoxicity in response to phytoncides. Furthermore, CT-26 colon cancer cells were allografted subcutaneously into BALB/c mice, and α-pinene treatment then inhibited allografted tumor growth. Our findings demonstrate that α-pinene activates NK cells and increases NK cell cytotoxicity, suggesting it is a potential compound for cancer immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Cha

Kim

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…It is well established that cell transformation results in increased NKG2DL expression in relation to their basal levels, thus converting these cells in a specific target for NK cell-mediated cytotoxicity, which may determine their elimination ( 8 , 9 ). However, high MICA and MICB expression in the primary tumor tissue may provide a selective advantage for tumor cells that sustain MICA and MICB expression and, instead of immune activation, this prevalent expression would promote immune suppression, since persistent NKG2DL expression may desensitize NK cells and render them dysfunctional, which is a determinant of tumor aggressiveness ( 21 , 46 , 47 ). However, it is worth mentioning that other factors, such as soluble NKG2DLs ( 19 ) and TGF-β released from tumors ( 48 ), may more strongly impair NK cell and other lymphocytes cytotoxicity, compromising their function and favoring malignant progression.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients

et al. 2015

View full text Add to dashboard Cite

Gastric cancer (GC) is the third most common cause of cancer death worldwide. Natural killer cells play an important role in the immune defense against transformed cells. They express the activating receptor NKG2D, whose ligands belong to the MIC and ULBP/RAET family. Although it is well established that these ligands are generally expressed in tumors, the association between their expression in the tumor and gastric mucosa and clinical parameters and prognosis of GC remains to be addressed. In the present study, MICA and MICB expression was analyzed, by flow cytometry, in 23 and 20 pairs of gastric tumor and adjacent non-neoplasic gastric mucosa, respectively. Additionally, ligands expression in 13 tumors and 7 gastric mucosa samples from GC patients were evaluated by immunohistochemistry. The mRNA levels of MICA in 9 pairs of tumor and mucosa were determined by quantitative PCR. Data were associated with the clinicopathological characteristics and the patient outcome. MICA expression was observed in 57% of tumors (13/23) and 44% of mucosal samples (10/23), while MICB was detected in 50% of tumors (10/20) and 45% of mucosal tissues (9/20). At the protein level, ligand expression was significantly higher in the tumor than in the gastric mucosa. MICA mRNA levels were also increased in the tumor as compared to the mucosa. However, clinicopathological analysis indicated that, in patients with tumors >5 cm, the expression of MICA and MICB in the tumor did not differ from that of the mucosa, and tumors >5 cm showed significantly higher MICA and MICB expression than tumors ≤5 cm. Patients presenting tumors >5 cm that expressed MICA and MICB had substantially shorter survival than those with large tumors that did not express these ligands. Our results suggest that locally sustained expression of MICA and MICB in the tumor may contribute to the malignant progression of GC and that expression of these ligands predicts an unfavorable prognosis in GC patients presenting large tumors.

show abstract

“…Therefore, targeting CXCR2 may represent a novel therapeutic strategy for breast cancers. Other genes, such as vasoactive intestinal polypeptide (VIP) could inhibit the cytotoxicity of NK cells and could inhibit its expressions of some immune-associated genes like NKG2D and NF-κB [53]. Neurotensin (NTS) belong to Neuropeptide G protein-coupled receptors (GPCRs) are over-expressed in numerous cancer cells and were reported to stimulate tumor growth [54].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive multi-omics analysis identifies an immune related predicting model in early stage breast cancer

Li¹,

Jin²

2020

Preprint

View full text Add to dashboard Cite

Background Breast cancer is known the highest incidence cancer in women. Tumor-infiltrating immune cells were reported closely related to cancers’ fate but it’s function still not very clear in breast cancer. The aim of our study is to build a infiltrating immune cells based nomogram model to better predict patients survival and explore its relationship with immune features. Methods We first use CIBERSORT to analyze 22 immune cells’ status in two unrelated breast cancer cohorts (TCGA and METRABRIC). The univariate and multivariate Cox analyses were used to analyze the prognostic ability of immune cells and other clinicopathological factors. Nomogram model were built by using independent prognostic factors. Different immune signatures and gene enrichment analysis were performed in different nomogram risk groups. Results Multivariate cox analysis showed that Macrophages M2 with HR of 1.733 (95% CI: 1.013-2.966) in TCGA cohort and 1.334 (95% CI: 1.125-1.581) in METABRIC cohort is the only independent prognostic factor among the 22 immune cells in early stage breast cancer. Macrophages M2, age, TNM stage and molecular types were used to build the nomogram model. The AUC of the ROC of nomogram reached 0.732 in TCGA cohort and 0.702 in METABRIC cohort. Using the nomogram score can better classified patients to low and high risk group. High risk group showed higher malignant signatures and predicted immunotherapy response rates than low risk group which consistent with the gene entrenchment analysis. Conclusion In this study, we revealed that M2 macrophages could predict the OS of breast cancer patients. Based on M2 and other clinical features we established a nomogram model which were significantly different in immune features that can better assess the OS risk or be a predictor for the immunotherapy response in breast cancer for further research.

show abstract

Effect of Vasoactive Intestinal Peptide (VIP) on NKG2D Signal Pathway and Its Contribution to Immune Escape of MKN45 Cells

Cited by 6 publications

References 31 publications

α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

α-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway

Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients

Comprehensive multi-omics analysis identifies an immune related predicting model in early stage breast cancer

Contact Info

Product

Resources

About