Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency: the ACVID randomised clinical trial

Espinosa, Rubén Andújar; Salinero-González, Lourdes; Illán-Gómez, Fátima; Castilla-Martínez, Manuel; Hu-Yang, Chunshao; Ruíz-López, Francisco José

doi:10.1136/thoraxjnl-2019-213936

Cited by 31 publications

(35 citation statements)

References 27 publications

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“…In a study by Andujar-Espinosa et al, majority of the patients (78%) were women. 19 The most common age group to be affected is the paediatric age group followed by the elderly.…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D deficiency and lung function in asthma patients

Sowjanya¹,

Ravindranath

2021

IJIRM

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Asthma is an inflammatory disorder, usually chronic, and is related to the hypersensitivity of the airways to allergens leading to dyspnoea, wheezing, cough and tightness in chest. Increased severity of asthma and poor control has been attributed to lower levels of Vitamin D levels. Blood was collected from 78 patients who were diagnosed with asthma and tested for Vitamin D levels eosinophil counts, IgE levels, and regular biochemical tests. All these patients underwent Asthma Control Test, Pulmonary Function tests for FEV1%, FVC%, FEV1/FVC%. : The serum eosinophil count, sputum eosinophil count and IgE levels were significantly higher in Vitamin D deficient patients compared to the sufficient patients. The most common severity of asthma among the patients was due to atopy as seen in 53.8% of the patients. In 39.6% of the patients who were Vit D deficient, the asthma was very severe as was the case in 8% of the Vit D sufficient people. The Forced expiratory volume, Forced vital capacity and FEV1/FVC1 was 92.69 ± 0.9 %, 91.3 ± 12.1% and 76.2 ± 8.7 in patients with deficient Vitamin D levels and 97.36 ± 1.1%, 99.1 ± 7.3% and 81.6 ± 13.1 in patients with sufficient Vit D levels respectively. There seems to be a strong association of Vitamin D levels and asthma among patients. High vitamin D levels are beneficial to the lung function and also slow the asthma exacerbations.

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“…In a study by Andujar-Espinosa et al, majority of the patients (78%) were women. 19 The most common age group to be affected is the paediatric age group followed by the elderly.…”

Section: Discussionmentioning

confidence: 99%

Association between Vitamin D deficiency and lung function in asthma patients

Sowjanya¹,

Ravindranath

2021

IJIRM

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“…Vitamin D supplementation may reduce skin inflammation in subsets of atopic dermatitis patients who have recurrent bacterial infection and pre-existing vitamin D deficiency, however further placebo-controlled randomised control trials are needed to confirm these effects in other cohorts ( 276 ). A randomised clinical trial found that patients with asthma and vitamin D deficiency had significantly improved asthma control after 6 months of weekly oral calcifediol (1,25 dihydroxy vitamin D3) supplementation compared to placebo ( 277 ). Indeed, long-term supplementation with vitamin D may also be protective against inflammatory disease.…”

Section: Utilising Dietary Therapy In the Treatment Of Human Gastroin...mentioning

confidence: 99%

The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease

et al. 2022

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Diet is an important lifestyle factor that is known to contribute in the development of human disease. It is well established that poor diet plays an active role in exacerbating metabolic diseases, such as obesity, diabetes and hypertension. Our understanding of how the immune system drives chronic inflammation and disease pathogenesis has evolved in recent years. However, the contribution of dietary factors to inflammatory conditions such as inflammatory bowel disease, multiple sclerosis and arthritis remain poorly defined. A western diet has been associated as pro-inflammatory, in contrast to traditional dietary patterns that are associated as being anti-inflammatory. This may be due to direct effects of nutrients on immune cell function. Diet may also affect the composition and function of gut microbiota, which consequently affects immunity. In animal models of inflammatory disease, diet may modulate inflammation in the gastrointestinal tract and in other peripheral sites. Despite limitations of animal models, there is now emerging evidence to show that anti-inflammatory effects of diet may translate to human gastrointestinal and inflammatory diseases. However, appropriately designed, larger clinical studies must be conducted to confirm the therapeutic benefit of dietary therapy.

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“…The ACVID clinical trial [45], which was published in 2020, included 112 asthmatic patients with 25(OH)D deficiency and was based on a short follow-up period of six months. The authors administered calcifediol to treat 25(OH)D deficiency.…”

Section: Vitamin D Deficiency and Asthmamentioning

confidence: 99%

“…Furthermore, calcifediol does not require hepatic 25-hydroxylation. Functional impairment of CYP2R1 activity has been reported in patients with obesity, malabsorption [160] or inflammatory lung diseases such as COPD or asthma [45,59].…”

Section: Vitamin D and Other Respiratory Diseasesmentioning

confidence: 99%

Calcifediol for Use in Treatment of Respiratory Disease

et al. 2022

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Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic hydroxylation, it is a good option to replace the prevalent deficiency of vitamin D (25 hydroxyvitamin D; 25OHD), to which patients with respiratory pathologies are no strangers. Correcting 25OHD deficiency can decrease the risk of upper respiratory infections and thus improve asthma and COPD control. The same happens with other respiratory pathologies and, in particular, COVID-19. Calcifediol may be a good option for raising 25OHD serum levels quickly because the profile of inflammatory cytokines exhibited by patients with inflammatory respiratory diseases, such as asthma, COPD or COVID-19, can increase the degradation of the active metabolites of the VDES. The aim of this narrative revision is to report the current evidence on the role of calcifediol in main respiratory diseases. In conclusion, good 25OHD status may have beneficial effects on the clinical course of respiratory diseases, including COVID-19. This hypothesis should be confirmed in large, randomized trials. Otherwise, a rapid correction of 25(OH)D deficiency can be useful for patients with respiratory disease.

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Effect of vitamin D supplementation on asthma control in patients with vitamin D deficiency: the ACVID randomised clinical trial

Cited by 31 publications

References 27 publications

Association between Vitamin D deficiency and lung function in asthma patients

Association between Vitamin D deficiency and lung function in asthma patients

The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease

Calcifediol for Use in Treatment of Respiratory Disease

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