Effect of Vitamin E-Modified Regenerative Cellulose Membrane on Neutrophil Superoxide Anion Radical Production and Lipid Peroxidation

Shimazu, Takekazu; Kondo, Shinkichi; Toyama, Katsuhide; Komurai, Miki; Ohminato, M; Yasuda, Tomohiro; Sato, Toshinobu; Maeba, Teruhiko; Maruyama, Hiroaki; Owada, Shigeru; Ishida, M

doi:10.1159/000060007

Cited by 6 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Data on RBC superoxide dismutase (SOD) activity were available in 5 studies [11,26,49,55,58] . Plasma malondialdehyde (MDA) was measured in 13 studies [11,14,18,25,36,40,41,49,50,54,58,63,71], while 4 studies [36,42,63,71] provided data on RBC MDA. Twenty one studies [10, 11, 17, 24, 28, 30-32, 37, 38, 44, 46-49, 51, 54, 57, 58, 63, 71] examined the effect of ViE-m or conventional membranes on blood vitamin E levels, while 5 studies [11,37,42,58,71] 104 vitamin E levels.…”

Section: Outcome Datamentioning

confidence: 99%

“…Six studies [11,16,26,30,49,63] focused on blood vitamin C levels. Variation in plasma oxidized low density lipoprotein (Ox-LDL), nitric oxide (NOx) and thiobarbituric acid reactive substances (TBARS) were given in 11 [18,19,24,25,46,48,51,56,65,67,70] , 4 [16,22,57,62] and 8 studies [20,26,29,33,39,44,47,70] , respectively. Thirteen studies [10,20,23,26,30,33,44,48,49,51,58,64,70] reported information on total anti-oxidant status (TAS) and anti-oxidant capacity (AOC).…”

Section: Outcome Datamentioning

confidence: 99%

“…fig. 5 d) [11,25,40,41,49,50,54,58,63,71] . The high heterogeneity observed in this analysis (chi 2 = 34.85, p = 0.0001; I 2 = 71%) was notably reduced (I 2 = 41%) after excluding data from the only multicenter cross-over non-RCT [11] .…”

Section: Effects Of Vie-m On Oxidative Stressmentioning

confidence: 99%

“…7 b) [19,25,51,56,65,67,70] . In a sensitivity analysis excluding 3 parallel studies [25,67,70] , the heterogeneity was more than halved and Ox-LDL levels were significantly reduced (I 2 = 35%; SMD -1.26; 95% CI -1.79 to -0.74; fig. 7 c).…”

Section: Effects Of Vie-m On Oxidative Stressmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

show abstract

Section: Outcome Datamentioning

confidence: 99%

Section: Outcome Datamentioning

confidence: 99%

Section: Effects Of Vie-m On Oxidative Stressmentioning

confidence: 99%

Section: Effects Of Vie-m On Oxidative Stressmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Vitamin E (α‐tocopherol) coating was first introduced with cellulosic membrane and later with polysulfone (PS), which has been commercially available for anti‐oxidation purpose. Although vitamin E‐coated dialysis membrane has been evaluated from the biological, anticoagulation, and/or biocompatible points of view, its mass transfer characteristic has not yet been extensively examined.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of solute penetration across the polysulfone membrane with vitamin E coating

Yamashita

Masaki

Kobayashi

et al. 2015

Hemodialysis International

View full text Add to dashboard Cite

Vitamin E (vit E) is coated on polysulfone (PS) dialysis membrane for antioxidative purpose. The membrane, however, has not yet been evaluated from the mass transfer point of view. We investigated this PS membrane with and without vit E coating in vitro ultrafiltration experiments to identify whether or not the coating influences the mass transfer. Dialyzers that included PS membrane with and without vit E coating were investigated. Aqueous test solution of various solutes including vitamin B12 (VB12 , MW1355), chymotrypsin (chymo, MW25000), and albumin (alb, MW66000) was prepared, and normal ultrafiltration experiments were performed at 310 K. Reverse ultrafiltration experiments in which test solution was filtered from outside to inside the hollow fiber were also performed. Sieving coefficients (SC) were computed for evaluation. SC for VB12 was the same regardless of vit E coating; however, chymo was 0.82 ± 0.01 and 0.86 ± 0.01, respectively, for the membrane with and without vit E. Thus, it would be understood that vit E coating reduces the pore size of the membrane, resulting the reduced transport of larger solutes. Like other PS membrane, SC for alb was decreased over time regardless of vit E coating. More importantly, although the steady-state SC for alb was almost identical in two membranes, PS without vit E showed much greater decrease for the first 2 h, while that with vit E showed very little decrease over time, which suggested the reduced fouling effect due to vit E coating. All the SC values found in reverse ultrafiltration were higher than those found in normal ultrafiltration; moreover, the degree of increase with chymo was approximately 5%, whereas that with alb was approximately 430%, which may be explained by a new model in which wedge effect is taken into consideration for the membrane transport. Vit E coating not only has antioxidative effect but also reduces the fouling that is usually caused by various proteins.

show abstract

Development of vitamin E-modified polysulfone membrane dialyzers

Sasaki

2006

J Artif Organs

View full text Add to dashboard Cite

Oxygen radicals have recently been attracting close attention because of their involvement in tissue damage and their close relationship to various clinical conditions. It has been suggested that hemodialysis increases oxidative stress, triggering the development of complications such as atherosclerosis and dialysis-related amyloidosis. We recently developed a dialyzer containing a highly functional polysulfone membrane on which vitamin E had been bonded (PS-ViE). The present study was undertaken to evaluate the biocompatibility of this membrane and to conduct other experiments on the membrane in vitro. Human blood was dialyzed with minidialyzers (300-600 cm(2) membrane area) made of PS-ViE, cellulose, or untreated polusulfone (PS), and the effects of the dialyzers on complements (C3a, C4a, and C5a), cytokines (IL-1beta and IL-8), and granulocyte elastase as well as their anti-oxidative activity were investigated (n = 6). The effect of PS-ViE on complement activation and its effects on cytokines were comparable to those of PS membrane, whereas granulocyte elastase following dialysis with the PS-ViE membrane tended to be lower than that seen with PS membrane. The effects of PS-ViE-induced methemoglobin, lipid peroxide, and oxygen radicals were significantly less than those of PS membrane, indicating the antioxidative activity of PS-ViE. Vitamin E-modified polysulfone membrane dialyzers were found to have favorable effects on the immune system and to express antithrombotic and antioxidative effects.

show abstract

Effect of Vitamin E-Modified Regenerative Cellulose Membrane on Neutrophil Superoxide Anion Radical Production and Lipid Peroxidation

Cited by 6 publications

References 9 publications

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Evaluation of solute penetration across the polysulfone membrane with vitamin E coating

Development of vitamin E-modified polysulfone membrane dialyzers

Contact Info

Product

Resources

About