Effect of vitamin E on tamoxifen-treated breast cancer cells

Peralta, Elizabeth A.; Viegas, Melita; Louis, Somaja; Engle, Deborah L.; Dunnington, Gary L.

doi:10.1016/j.surg.2006.07.007

Cited by 28 publications

(23 citation statements)

References 33 publications

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“…a-T was reported as a Tamoxifen antagonist for breast cancer therapy [23,61,62], whereas T 3 s, especially d-T 3 and c-T 3, shown strong synergistic anticancer effect with Tamoxifen [23], statin [88,89] and celecoxib [74]. a-T was also reported to attenuate the cholesterol lowering effect of T 3 [64].…”

Section: Chemo-preventionmentioning

confidence: 99%

Unleashing the untold and misunderstood observations on vitamin E

Gee¹

2010

Genes Nutr

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Paradoxically, meta-analysis of human randomized controlled trials revealed that natural but not synthetic α-tocopherol supplementation significantly increases all-cause mortality at 95% confidence interval. The root cause was that natural α-tocopherol supplementation significantly depressed bioavailability of other forms of vitamin E that have better chemo-prevention capability. Meta-analysis outcome demonstrated flaws in the understanding of vitamin E. Reinterpretation of reported data provides plausible explanations to several important observations. While α-tocopherol is almost exclusively secreted in chylomicrons, enterocytes secrete tocotrienols in both chylomicrons and small high-density lipoproteins. Vitamin E secreted in chylomicrons is discriminately repacked by α-tocopherol transfer protein into nascent very low-density lipoproteins in the liver. Circulating very low-density lipoproteins undergo delipidation to form intermediate-density lipoproteins and low-density lipoproteins. Uptake of vitamin E in intermediate-density lipoproteins and low-density lipoproteins takes place at various tissues via low-density lipoproteins receptor-mediated endocytosis. Small high-density lipoproteins can deliver tocotrienols upon maturation to peripheral tissues independent of α-tocopherol transfer protein action, and uptake of vitamin E takes place at selective tissues by scavenger receptor-mediated direct vitamin E uptake. Dual absorption pathways for tocotrienols are consistent with human and animal studies. α-Tocopherol depresses the bioavailability of α-tocotrienol and has antagonistic effect on tocotrienols in chemo-prevention against degenerative diseases. Therefore, it is an undesirable component for chemo-prevention. Future research directions should be focused on tocotrienols, preferably free from α-tocopherol, for optimum chemo-prevention and benefits to mankind.

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Section: Chemo-preventionmentioning

confidence: 99%

Unleashing the untold and misunderstood observations on vitamin E

Gee¹

2010

Genes Nutr

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“…We have previously conducted in vitro studies of the effect of vitamin E on tamoxifen-treated breast cancer cells [4]. Estrogen receptor (ER)ϩ cell lines MCF7 and T47D were treated in vitro with 20 M tamoxifen (TAM) alone and in combination with 10 M ␣-tocopherol acetate (AT).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E Increases Biomarkers of Estrogen Stimulation When Taken With Tamoxifen

Peralta

Brewer

Louis

et al. 2009

Journal of Surgical Research

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“…Increased Vitamin E level in serum have been reported to decease lipid peroxidation and decease protein kinase C. 5-lipooxygenaze smooth muscle cell proliferation, platelet aggregation and oxygen burst in neutrophil [23] [24].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin E, a free-radical scavenger in the lipid compartments of cells and serum is known for its beneficial antioxidant effects for a number of chronic diseases including cancer [22]. Increased serum Vitamin E levels have been reported to decrease lipid peroxidation, inhibit protein kinase C, 5-lipoxygen-ase,smooth muscle cell proliferation, platelet aggregation and oxygen burst in neutrophils and the oxygen burst in neutrophils [23] [24].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Grape Seed Extract on Cardiotoxicity Induced by Doxorubicin Drug in Male Rats

Al-Sowayan¹,

Mahmoud²

2014

ABB

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Objective: This work was designed to determine the productive effect of grape seed proanthocynadine extract (GSPE) and Vitamin E against Doxorubicin (DOX) induced myocardial toxicity in 50 male. Wister rates were divided in five groups. The 1 st group was untreated and served as a control. The 2 nd group was treated with DOX only, the 3 rd group was pretreated with GSPE, the 4 th group was pretreated with Vitamin E, and the 5 th group was pretreated with GSPE and Vitamin E. DOX was administered by single i.p (Intraperitonial) injection of 15 mg/kg/body weight to induce cardio toxicity and Vitamin E was administered at a dose of 400 IU/kg/bodyweight/day, p.o (per oral) for 10 days prior to DOX administration [1]. GSPE was given at a dose of 150 mg/kg/bodyweight/ day, p.o (per oral) for 10 days before treatment with DOX. After 2 weeks experimental period, blood samples and heart tissues were taken from all groups. The general observations, mortality, histopathology, biomarker enzymes like Lactate Dehydrogenase (LDH), Creatine Phosphokinase (CPK), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Antioxidants such as Glutathione (GSH), Superoxide dismutase (SOD), Catalase (CAT) and Malondialdehyde (MDA) were monitored after 2 weeks of the last dose. Results: Administration of DOX caused cardiomyopathy associated with an antioxidant deficiency. Pretreatment with GSPE and Vitamin E significantly (P < 0.01) protected the myocardium from the toxic effects of DOX by reducing the elevated level of biomarkers and diagnostic enzymes like LDH, CPK, AST, and ALT to normal levels. GSPE and Vitamin E increased the GSH, SOD and CAT levels and decreased the MDA levels in cardiac tissue. Conclusion: These results suggest a cardioprotective effect of GSPE and Vitamin E due to its antioxidant properties.

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Effect of vitamin E on tamoxifen-treated breast cancer cells

Cited by 28 publications

References 33 publications

Unleashing the untold and misunderstood observations on vitamin E

Unleashing the untold and misunderstood observations on vitamin E

Vitamin E Increases Biomarkers of Estrogen Stimulation When Taken With Tamoxifen

The Protective Effect of Grape Seed Extract on Cardiotoxicity Induced by Doxorubicin Drug in Male Rats

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