Effect of vitamin E supplementation on lipid peroxidation in blood and lung of influenza virus infected mice

Mileva, Milka; Bakalova, Rumiana; Tancheva, Lyubka; Galabov, Angel S.; Ribarov, S. R.

doi:10.1016/s0147-9571(01)00010-8

Cited by 27 publications

(34 citation statements)

References 26 publications

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“…This could be supported by the results for the ␣ -tocopherol concentration in the blood. It is known from other investigations [31] that as a consequence of increased oxidative load a decrease in the concentration of antioxidative substances in the blood occurs. On this account it was expected that the concentration of ␣ -tocopherol in plasma would decrease in the group fed fat meat.…”

Section: Discussionmentioning

confidence: 99%

Relevance of Meat Fat Content and Fruit and Vegetable Intake for the Oxidative Status of Pigs

et al. 2006

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Background: The aim of the present study was to evaluate the effect of substituting lean meat with fat meat on oxidative stress in a diet with or without fruit and vegetables. Methods: Thirty-two pigs were divided into groups and fed isocaloric daily rations: LM+FV (balanced diet with lean meat and fruit and vegetables); FM+FV (as LM+FV, but lean meat was substituted with fat meat); LM–FV (as LM+FV, but without fruit and vegetables), and FM–FV (as FM+FV, but without fruit and vegetables). Oxidative stress was evaluated by measuring the 24-hour urine malondialdehyde excretion rate, the degree of leukocyte nuclear DNA damage, the concentration of tocopherols in blood plasma, erythrocyte glutathione peroxidase activity and the total antioxidant status of plasma. Results: The substitution of lean meat with fat meat modestly increased the rate of leukocyte DNA damage only in the diet with fruit and vegetables but had no effect in the group deprived of fruit and vegetables. Regardless of the fruit and vegetable content of the diet, the substitution of lean meat with fat meat did not affect any other parameters measured. In comparison to both fruit- and vegetable-containing diets, the deprivation of fruits and vegetables in the LM–FV and FM–FV groups significantly increased the rate of leukocyte DNA damage and reduced the plasma α-tocopherol level (significant only for FM+FV). Conclusion: The substitution of fat meat with lean meat in a diet with or without fruit and vegetables has only a marginal or no effect on oxidative stress. But fruit and vegetable exclusion markedly increased the level of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Relevance of Meat Fat Content and Fruit and Vegetable Intake for the Oxidative Status of Pigs

et al. 2006

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“…This opens the possibility that seasonal variations in nutrient availability and/or requirements on diet might also have a role on influenza seasonality. Experimental studies in mice suggest that the supplementation of vitamin C (Li et al 2006) and vitamin E (Han et al 2000; Mileva et al 2002) can diminish the severity of influenza infection. Selenium deficiency has also a negative effect on host immune response and the severity of infection in human airway epithelial cells (Jaspers et al 2007).…”

Section: Seasonal Variations In Immunitymentioning

confidence: 99%

Global Influenza Seasonality: Reconciling Patterns across Temperate and Tropical Regions

Tamerius

Nelson

Zhou

et al. 2011

Environ Health Perspect

439

460

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BackgroundDespite the significant disease burden of the influenza virus in humans, our understanding of the basis for its pronounced seasonality remains incomplete. Past observations that influenza epidemics occur in the winter across temperate climates, combined with insufficient knowledge about the epidemiology of influenza in the tropics, led to the perception that cool and dry conditions were a necessary, and possibly sufficient, driver of influenza epidemics. Recent reports of substantial levels of influenza virus activity and well-defined seasonality in tropical regions, where warm and humid conditions often persist year-round, have rendered previous hypotheses insufficient for explaining global patterns of influenza.ObjectiveIn this review, we examined the scientific evidence for the seasonal mechanisms that potentially explain the complex seasonal patterns of influenza disease activity observed globally.MethodsIn this review we assessed the strength of a range of hypotheses that attempt to explain observations of influenza seasonality across different latitudes and how they relate to each other. We reviewed studies describing population-scale observations, mathematical models, and ecological, laboratory, and clinical experiments pertaining to influenza seasonality. The literature review includes studies that directly mention the topic of influenza seasonality, as well as other topics we believed to be relevant. We also developed an analytical framework that highlights the complex interactions among environmental stimuli, mediating mechanisms, and the seasonal timing of influenza epidemics and identify critical areas for further research.ConclusionsThe central questions in influenza seasonality remain unresolved. Future research is particularly needed in tropical localities, where our understanding of seasonality remains poor, and will require a combination of experimental and observational studies. Further understanding of the environmental factors that drive influenza circulation also may be useful to predict how dynamics will be affected at regional levels by global climate change.

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“…This contrasts Hayek et al's data, 22 which showed that six-week vitamin E supplementation decreased lung virus titers in mice subsequently infected with influenza virus A (H3N2). In our previous study, 23,24 we found some protective effect of a-tocopherol at virus infection with 2 MLD 50 .…”

Section: Discussionmentioning

confidence: 75%

“…These occur in parallel with a decrease in the level of endogenous lipid-and water-soluble antioxidants as well as compensatory changes in antioxidant enzyme activity. 23,24,29,34 Lung disorders associated with influenza virus infection may be triggered by (i) a massive infiltration of leukocytes, mainly polymorphonuclear leukocytes, into the alveolar space after influenza virus inoculation; (ii) a decrease in partial oxygen pressure and the development of hypoxia; (iii) an increase in partial CO 2 pressure and the development of metabolic acidosis; (iv) a release of cytokines, eicosanoids, and prostaglandin E2 and enhanced immune response; or (v) the development of oxidative stress. 4,6,18,22 It is well known that antioxidants are able to prevent oxidative damage during the course of influenza virus infection.…”

Section: Discussionmentioning

confidence: 99%

“…18,[21][22][23][24][25][26][27] However, researchers have shown that endogenic levels of vitamin E are significantly decreased in lung, liver, and blood plasma during the course of influenza infection. 23,24,28 Animal and human studies have demonstrated a negative correlation between endogenous levels of vitamin E and pulmonary inflammation. Vitamin E supplementation has been associated with reducing the severity of symptoms of lung disease.…”

Section: Introductionmentioning

confidence: 99%

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Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice

Galabov

Mileva

Simeonova

et al. 2015

Antivir Chem Chemother

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Effect of vitamin E supplementation on lipid peroxidation in blood and lung of influenza virus infected mice

Cited by 27 publications

References 26 publications

Relevance of Meat Fat Content and Fruit and Vegetable Intake for the Oxidative Status of Pigs

Relevance of Meat Fat Content and Fruit and Vegetable Intake for the Oxidative Status of Pigs

Global Influenza Seasonality: Reconciling Patterns across Temperate and Tropical Regions

Combination activity of neuraminidase inhibitor oseltamivir and α-tocopherol in influenza virus A (H3N2) infection in mice

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