Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats

Zhang, Linlin; Feng, Yi; Ji, Wenliang; Liu, Jianzhang; Liu, Kun

doi:10.1155/2017/6137071

Cited by 18 publications

(6 citation statements)

References 57 publications

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“…Consistently with previous studies, 1 study found that rats induced anxiety-like behavior and decreased exploratory activity in open field tests compared to age-matched controls, 37 our preliminary research reported that the time spent of open arms in the molar loss group was significantly shorter 38 ; the present study used all 3 tests to determine more accurately the presence of anxiety-like behavior in rats with vascular dementia. In addition, our previous experiments also used the open field to discriminate anxiety-like behavior in rats, which produced inconsistent results with our present experimental results.…”

Section: Discussionsupporting

confidence: 90%

Different Exercise Time on 5-HT and Anxiety-like Behavior in the Rat With Vascular Dementia

Fan

Zhang

Kong

et al. 2022

Am J Alzheimers Dis Other Demen

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Background Previous studies have demonstrated that pre-exercise suppresses anxiety-like behavior, but the effects of different exercise times on vascular dementia induced anxiety-like behavior have not been well investigated. Objective The present study aims to investigate the underlying neurochemical mechanism of different pre-vascular-dementia exercise times on 5-HT and anxiety-like behavior in rats with vascular dementia. Methods 32 Sprague-Dawley (SD) rats were randomly divided into 4 groups: sham group (S group, n = 8), vascular dementia group (VD group, n = 8), 1-week physical exercise and vascular dementia group (1WVD group, n = 8), and 4 weeks physical exercise and vascular dementia group (4WVD group, n = 8). 1 week and 4 weeks of voluntary wheel running were used as pre-exercise training. The vascular dementia model was established by bilateral common carotid arteries occlusion (BCCAo) for 1 week. But bilateral common carotid arteries were not ligated in the sham group. The level of hippocampal 5-HT was detected with in vivo microdialysis coupled with high-performance liquid chromatography (MD-HPLC). Elevated plus maze (EPM), open field (OF), and light/dark box test were used to test anxiety-like behavior. Results Compared with the C group, the hippocampal 5-HT was significantly decreased in the VD group after 1 week of ligated operation. The hippocampal 5-HT levels in 1WVD and 4WVD groups were substantially higher than the level in the VD group. The hippocampal 5-HT level has no significant difference among C, 1WVD, and 4WVD. Behavioral data suggested that the rats in the VD group developed obvious anxiety-like behavior after 1 week of ligation surgery. Still, the rats in 1WVD and 4WVD groups did not show significant anxiety-like behavior. Conclusion Both 1 week and 4 weeks of voluntary running wheel exercise can inhibit the anxiety-like behavior in rats with vascular dementia by upregulating 5-HT levels in the hippocampus in the VD model.

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Section: Discussionsupporting

confidence: 90%

Different Exercise Time on 5-HT and Anxiety-like Behavior in the Rat With Vascular Dementia

Fan

Zhang

Kong

et al. 2022

Am J Alzheimers Dis Other Demen

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“…Although most reports prove that physical activity positively affects motor functions (19, 34, 44, 47–50, 72) and increases the level of DA in the striatum (19, 73), there are also studies reporting the lack of effects of physical exercise on these parameters (22, 52, 53, 55). For example, Gerecke et al (65) have found that, even though 3 months of training completely protected dopaminergic neurons against MPTP-induced neurotoxicity, the level of DA and its metabolites in the striatum was significantly lower compared to controls.…”

Section: Exercise Induces Recovery Of Motor Function and Neuroprotectmentioning

confidence: 99%

Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease

et al. 2019

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Parkinson's disease (PD) is manifested by progressive motor, autonomic, and cognitive disturbances. Dopamine (DA) synthesizing neurons in the substantia nigra (SN) degenerate, causing a decline in DA level in the striatum that leads to the characteristic movement disorders. A disease-modifying therapy to arrest PD progression remains unattainable with current pharmacotherapies, most of which cause severe side effects and lose their efficacy with time. For this reason, there is a need to seek new therapies supporting the pharmacological treatment of PD. Motor therapy is recommended for pharmacologically treated PD patients as it alleviates the symptoms. Molecular mechanisms behind the beneficial effects of motor therapy are unknown, nor is it known whether such therapy may be neuroprotective in PD patients. Due to obvious limitations, human studies are unlikely to answer these questions; therefore, the use of animal models of PD seems indispensable. Motor therapy in animal models of PD characterized by the loss of dopaminergic neurons has neuroprotective and neuroregenerative effects, and the completeness of neuronal protection may depend on (i) degree of neuronal loss, (ii) duration and intensity of exercise, and (iii) time elapsed between insult and commencing of training. As the physical activity is neuroprotective for dopaminergic neurons, the question arises what is the mechanism of this protective action. A current hypothesis assumes a central role of neurotrophic factors in the neuroprotection of dopaminergic neurons, even though it is still not clear whether increased DA level in the nigrostriatal axis results from neurogenesis of dopaminergic neurons in the SN, recovery of the phenotype of dopaminergic neurons, increased sprouting of the residual dopaminergic axons in the striatum, or generation of local striatal neurons from inhibitory interneurons. In the present review, we discuss studies describing the influence of physical exercise on the PD-like changes manifested in animal models of the disease and focus our interest on the current state of knowledge on the mechanism of neuroprotection induced by physical activity as a supportive therapy in PD.

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“…HPLC analysis of the brain of rats suffering from tooth loss showed dopamine levels of 26.48 ± 6.67 fmol against normal rat's 55.02 ± 9.05 fmol. After wheel running for one week, the level rose to 50.01 ± 10.52 fmol and after four weeks dopamine level was 52.34 ± 12.54 fmol which was quite close to normal control and indicated wheel running exercise increased dopamine levels [ 82 ]. In literature, other plants are also reported for their involvement in brain neurotransmitters by ethanolic extract of Tylophora indica , increased dopamine levels of 30.655 ± 0.55 × 10 3 units/g in alcohol-toxic albino rats from an initial level of 3.283 ± 0.172 × 10 3 units/g [ 83 ].…”

Section: Resultsmentioning

confidence: 98%

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

Ismail

Khalid

Ayub

et al. 2023

BioMed Research International

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Phoenix dactylifera is known for medicinal importance due to its antioxidant, antidiabetic, antidepressant, and anti-inflammatory properties. This study is aimed at evaluating the effect of P. dactylifera seeds to cure Alzheimer’s disease (AD). AD was induced in the rats with streptozotocin + aluminium chloride followed by treatment of methanolic extract of P. dactylifera seeds. The blood glucose levels were determined at regular intervals, which showed a prominent decrease in the extracts treated group. Behavior tests, including the Elevated Plus Maze (EPM) test and Morris Water Maze (MWM) test, were used to evaluate memory patterns in rats. The results indicated that extract-treated rats significantly improved memory behavior compared to the diseased group. After dissection, the serum electrolytes, antioxidant enzymes, and choline esterase enzymes were measured in different organs. The serum parameters creatinine, urea, and bilirubin increased after extract treatment. Similarly, the level of antioxidant enzymes like peroxidases (POD), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substance (TBARS) in the extract-treated group showed improved results that were close to the normal control group. The enzyme (lipase, insulin, amylase, and acetylcholine) levels were found enhanced in extract groups as compared to diseased rats. High-performance liquid chromatography (HPLC) was used to determine the level of dopamine and serotonin neurotransmitters, which were increased significantly for P. dactylifera seeds with values of 0.18 μg/mg tissue and 0.56 μg/mg tissue, respectively. Overall, results showed that P. dactylifera seeds proved to be quite efficient in improving the memory and behavior of treated rats. The antioxidants and enzymes were also increased; therefore, it may be a potential candidate for treating AD.

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Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats

Cited by 18 publications

References 57 publications

Different Exercise Time on 5-HT and Anxiety-like Behavior in the Rat With Vascular Dementia

Different Exercise Time on 5-HT and Anxiety-like Behavior in the Rat With Vascular Dementia

Exercise-Induced Neuroprotection and Recovery of Motor Function in Animal Models of Parkinson's Disease

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

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