Effect of water content on transparency, swelling, lidocaine diffusion in p-HEMA gels

Gulsen, Derya; Chauhan, Anuj

doi:10.1016/j.memsci.2005.06.024

Cited by 58 publications

(38 citation statements)

References 42 publications

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“…The transmittance values obtained fall within the range reported in literature for soft contact lenses materials [40,41]. These values remain practically constant after loading the hydrogels with the antibiotic (96.570.03% for PHEMA-T and 95.970.04% for PHEMA-UV).…”

Section: Characterization Of the Hydrogelssupporting

confidence: 86%

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Galante

Paradiso

Moutinho

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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Abstract:The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationConversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered. Powered by Editorial Manager® and ProduXion Manager® from Aries Systems CorporationAbout the effect of eye blinking on drug release from pHEMA based hydrogels:an in vitro study The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before.Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T.We observe that the load and friction cycles enhanced the drug release from pHEMA-UV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, show...

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Section: Characterization Of the Hydrogelssupporting

confidence: 86%

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Galante

Paradiso

Moutinho

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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“…4). Incorporation of drug shows more swelling of the matrix, and this may be because of the hygroscopic nature of lidocaine hydrochloride (47) and presence of water of crystallization in amoxicillin trihydrate. This might provide more water molecules deep inside of the Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The highest percentage of moisture uptake was obtained for lidocaine hydrochloride denticap. The reduced swelling ability of amoxicillin trihydrate denticap may be because of less water affinity of amoxicillin trihydrate than lidocaine hydrochloride (47,48) and presence of amoxicillin trihydrate in the matrix. The tackiness of the formulations was determined by tooth adhesion test.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dental Mold: A Novel Formulation to Treat Common Dental Disorders

2009

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Abstract. Oral administration of antibiotics to treat dental problems mostly yields slow actions due to slow onset and hepatic "first-pass." Again, commonly used dental paints are generally washed out by saliva within few hours of application. To overcome the challenges, polymeric molds to be placed on an affected tooth (during carries and gum problems) were prepared and evaluated in vitro for sustained drug release for prolonged local action. Here, amoxicillin trihydrate and lidocaine hydrochloride were used as model drugs. Dental molds were prepared using corn zein, carbopol 934 P, gum karaya powder, and poloxamer 407 by mixing and solvent evaporation technique. Different physicochemical evaluation studies such as tooth adhesion test, surface pH, swelling index, and drug-distribution pattern were carried out. Percentage swelling varied from 56% to 93%. Average tooth adhesion strength and mean initial surface pH of the formulations were 50 g and 6.5, respectively. As assessed by scanning electron microscopy, drug distribution was uniform throughout the matrix. Cumulative percentage release of lidocaine hydrochloride and amoxicillin trihydrate in simulated saliva were 98% and 50%, respectively. In vitro drug-release studies revealed the sustained-release patterns of the drugs in simulated saliva at least for 24 h. The stability study shows that the drugs were stable in the formulations following the conditions as per ICH guideline. The formulation is a novel approach to deliver the drug(s) for a prolonged period for local action upon its application on an affected tooth.

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“…Durch seine hydratisierte Struktur kann PVP den Wassergehalt anderer Polymere erhöhen. [174,175] Möglicherweise ist es eben jene starke Hydratation, welche die Wechselwirkungen mit dem Immunsystem minimiert. [174,175] Eine Studie mit verschiedenen Copolymeren aus Poly(hydroxyethylmethacrylat) (PHEMA) und PVP ergab, dass PVP keine Aktivierung von C3a bewirkt.…”

Section: Poly(vinylpyrrolidon)unclassified

Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen

et al. 2010

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Im stetig wachsenden Feld der Polymer‐basierten Wirkstoff‐Transport‐Systeme gilt Poly(ethylenglycol) (PEG) als der Goldstandard für Stealth‐Polymere. Welche Eigenschaften PEG aufweist, die diese herausragende Stellung rechtfertigen, soll in diesem Aufsatz diskutiert werden. Die ersten PEGylierten Produkte erschienen bereits vor 20 Jahren auf dem Markt. Seither konnten viele Erkenntnisse in klinischen Untersuchungen gewonnen werden, allerdings wurden dabei nicht nur Vorteile festgestellt, sondern auch mögliche Nebenwirkungen und Komplikationen bei der Anwendung aufgedeckt. Diese möglichen Nachteile, die eine tiefergehende Untersuchung erfordern, können in folgende Kategorien unterteilt werden: Hypersensitivität, Veränderungen der Pharmakokinetik, toxische Nebenprodukte sowie ein Abbauparadoxon, das aus der Etherstruktur resultiert: Einerseits kann das Polymer relativ einfach unter mechanischer Belastung abgebaut werden, andererseits wird jedoch ein biologischer Abbau verhindert, was bei In‐vivo‐Anwendungen zur Anreicherung im Körper führen kann. Der Aufsatz diskutiert diese möglichen Nachteile und stellt alternative Polymere vor.

show abstract

Effect of water content on transparency, swelling, lidocaine diffusion in p-HEMA gels

Cited by 58 publications

References 42 publications

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

About the effect of eye blinking on drug release from pHEMA-based hydrogels: anin vitrostudy

Dental Mold: A Novel Formulation to Treat Common Dental Disorders

Anwendung von Poly(ethylenglycol) beim Wirkstoff‐Transport: Vorteile, Nachteile und Alternativen

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