Effect of weight gain during adjuvant chemotherapy on survival in breast cancer

Atalay, Can; Küçük, Ali

doi:10.5152/ucd.2015.3123

Cited by 9 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Weight gain is consider one of the side effect to the chemotherapy treatment, this increase in the body mass index may be give explanation to the increase in the serotonin levels at cancerous patients during the treatment period through multi mechanisms based to the intake of food richly proteins, [37,38] alternative metabolic pathways of tryptophan [12], changes in the transport serotonin proteins, [39] reduction in the ability of different enzymes involved in the serotonin synthesis pathway, and serotonin receptors [31,40,41]. For monitoring the changes in the serum levels of serotonin with details; the cancer cases with the largest number of samples were selected, here the selected cases of the malignant patients group were subdivided into six different types (Breast, Lung, Brain, Bladder, Lymphoma, and Acute Lymphocytic Leukemia (ALL)) were enrolled in the present section.…”

Section: Resultsmentioning

confidence: 99%

Serotonin as a Marker to the Response of Patients with Advanced Stages of Cancer during Treatment with Chemotherapy and Radiotherapy

Jasim¹,

Matlab²

2017

Clin Med Biochemistry

View full text Add to dashboard Cite

Serotonin is synthesized by conversion L-tryptophan into 5-hydroxytryptamine in the body by using two catalyze factors are tryptophan hydroxylase and 5-hydroxytryptophan decarboxylase, it exhibits a growth stimulatory effect on several types of carcinoma, carcinoid and other tumor cells. In contrast, few data are available on serotonin involvement in cancer cell migration and metastatic processes. Serum serotonin level was found to be suitable for prognosis evaluation of urothelial carcinoma in the urinary bladder, adenocarcinoma of the prostate and renal cell carcinoma. Subjects: 201 patients with malignant tumors, 74 patients with different benign tumors and 83 healthy individuals were enrolled in the present study. Results: Outresults show a significant increase (p=0.011 and 0.043) of serum serotonin levels in malignant tumors group when compared with those of benign tumors (as a pathological controls) group, and healthy individuals groups; respectively. No such results were shown when the two control (benign tumors and healthy individuals) groups were compared together. Conclusion: Increase of serotonin could be related to activation of the serotonergic receptors sensitivity.

show abstract

Section: Resultsmentioning

confidence: 99%

Serotonin as a Marker to the Response of Patients with Advanced Stages of Cancer during Treatment with Chemotherapy and Radiotherapy

Jasim¹,

Matlab²

2017

Clin Med Biochemistry

View full text Add to dashboard Cite

show abstract

“…However, DPK treatment did not show any other effects on the gross metabolism of the study animals. Weight gain has been reported clinically as a side effect of chemotherapy ( Atalay and Küçük, 2015 ). The animals were monitored throughout the experimental regimen for any clinical sign of toxicity.…”

Section: Discussionmentioning

confidence: 99%

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

et al. 2020

View full text Add to dashboard Cite

The widely used cancer treatment, chemotherapy, causes severe long-term neuropathic pain in 30–40% cases, the condition clinically known as chemotherapy-induced peripheral neuropathy (CIPN). Approved conventional analgesics are sometimes ineffective, while others like opioids have undesirable side effects like addiction, seizures, and respiratory malfunctioning. Tricyclic antidepressants and anticonvulsants, although exhibit anti-allodynic effects in neuropathy, also have unpleasant side effects. Thus, alternative medicines are being explored for CIPN treatment. Despite scattered reports on different extracts from different plants having potential anti-allodynic effects against CIPN, no established medicine or formulation of herbal origin exists. In this study, efficacy of an herbal decoction, formulated based on ancient medicinal principles and protocols for treating neuropathic pain, Divya-Peedantak-Kwath (DPK), has been evaluated in a paclitaxel (PTX)-induced peripheral neuropathic mouse model. We observed that DPK has prominent anti-allodynic and anti-hyperalgesic effects and acts as a nociceptive modulator for CIPN. With exhibited antioxidative effects, DPK restored the redox potential of the sciatic nerves to the normal. On histopathological evaluation, DPK prevented the PTX-induced lesions in the sciatic nerve, in a dose-dependent manner. It also prevented inflammation by modulating the levels of pro-inflammatory cytokines involved in CIPN pathogenesis. Our observations evinced that DPK can alleviate CIPN by attenuating oxidative stress and concomitant neuroinflammation through immune modulation.

show abstract

“…The causes for weight gain after breast cancer diagnosis are unclear; however, they might involve changes in the woman' s energy metabolism, including reduced basal metabolic rate, decreased physical activity and thermogenesis, and increased food intake 20 . In our study, weight gain ranged from 0.8 to 4.8 kg, and more than 80% of patients showed overweight after treatment.…”

Section: Discussionmentioning

confidence: 99%

Breast cancer survivors have less lean mass and lower phase angle after cancer treatment

Justa¹,

Machado²,

Lima³

et al. 2019

Mastology

View full text Add to dashboard Cite

Avaliar o estado do peso e a composição corporal de mulheres sobreviventes do câncer de mama após tratamento oncológico. Metodologia: Trata-se de estudo clínico do tipo antes e depois, em que 27 pacientes sobreviventes do câncer de mama foram avaliadas antes (T0) e depois (T1) do tratamento oncológico (cirúrgico e clínico). Aferiram-se peso atual e estatura para definição do índice de massa corporal (IMC). A avaliação da composição corporal deu-se por impedância bioelétrica tetrapolar, sendo aferidos percentual de massa gorda e de massa magra e ângulo de fase. Aplicou-se o teste t de Student para avaliar a diferença de médias das variáveis antropométricas e de composição corporal entre T0 e T1, bem como o teste de McNemar para avaliar diferenças na prevalência de sobrepeso, adotando significância de 5%. Resultados: As pacientes têm aumento médio de 2,6 kg após o tratamento (p= 0,00) e 1,15 kg/m 2 no IMC (p= 0,00). O percentual de massa gorda aumenta 0,6% (p= 0,003) e há redução na massa magra (p=0,03) no T1. Em relação ao ângulo de fase, há diminuição média de 0,6 (p=0,026) após o tratamento. Conclusão: Mulheres sobreviventes do câncer de mama têm aumento de adiposidade, redução da massa magra e piora da integridade celular após o tratamento oncológico, o que sugere acréscimo de fatores de risco para recidiva da doença.

show abstract

Effect of weight gain during adjuvant chemotherapy on survival in breast cancer

Abstract: Weight gain during adjuvant chemotherapy has a negative effect on both disease-free and overall survival in patients with breast cancer.

Cited by 9 publications

References 22 publications

Serotonin as a Marker to the Response of Patients with Advanced Stages of Cancer during Treatment with Chemotherapy and Radiotherapy

Serotonin as a Marker to the Response of Patients with Advanced Stages of Cancer during Treatment with Chemotherapy and Radiotherapy

Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response

Breast cancer survivors have less lean mass and lower phase angle after cancer treatment

Contact Info

Product

Resources

About