Effect of XPD and TP53 Gene Polymorphisms on the Risk of Platinum-Based Chemotherapy Induced Toxicity in Bangladeshi Lung Cancer Patients

Abstract

22 (12), 3809-3815 most prevalent cancer in males considering an incidence rate of 14.2% (Sung et al., 2021). In Bangladesh, the estimated lung cancer patients were found to be 196,000, and among them, 85% are aged 30 years or above (Hussain and Sullivan, 2013). Following the data published by the World Health Organization in 2017, lung cancer deaths in Bangladesh rise to 12,075 or 1.53% of total deaths (WHO, 2017). According to the GLOBOCON 2020 report, there were 12,999 (8.3%) new lung cancer cases in Bangladesh in 2020, considering both sexes and all ages (Sung et al., 2021).

XRCC1 and XPD Polymorphisms: Clinical Outcomes and Risk of Prostate Cancer in Bangladeshi Population

“…The XRCC1 codon 194 and XPD 751 genotypes were determined using the PCR-RFLP technique. Brie y, two separate PCR assays were used to amplify the XRCC1 codon 194 and XPD codon 751 polymorphisms using primer sequences (Table 1) and PCR conditions following previously published papers [30][31][32]. Restriction enzymes PvuII for XRCC1 codon 194 and PstI for XPD codon 751 polymorphisms (New England Biolabs, USA) were used for restriction fragment analyses (Supplementary Figure S1 and S2).…”