Superconductivity in PrIr 2 Zn 20 appears at T c = 0.05 K in the presence of an antiferroquadrupolar order below T Q = 0.11 K. We have studied pressure dependences of T c , T Q , and non-Fermi liquid behaviors in the resistivity ρ(T ) by using two pressure transmitting media: argon maintaining highly hydrostatic pressure, and glycerol, which solidifies above 5 GPa producing nonhydrostatic pressure. Upon applying P with argon up to 10.6 GPa, T c hardly changes, while T Q monotonically increases from 0.11 to 0.23 K. With glycerol, however, T Q and T c simultaneously fall below 0.04 K at 6.3 GPa. The contrasting results indicate that onsite quadrupolar fluctuations induce superconductivity in this compound.