Effect of α-dextrin nanoparticles on the structure of iodine complexes with polypeptides and alkali metal halogenides, and on the mechanisms of their anti-human immunodeficiency virus and anticancer activity

The efficacy of combination the amoxicillin and new complex of iodine for lungs infection of mice caused by Klebsiella pneumonia

“…It forms a variety of compounds related to supramolecular chemistry [1]. These properties make it possible to obtain compounds with various pharmacological activities by complexation with bioorganic ligands, such as amino acids and carbohydrates [2]. For example, iodine adducts with dextrin and lithium cation is effective against gram-positive and gramnegative bacteria.…”

“…International Journal of Biology and Chemistry 14, № 1, 141 (2021) especially against resistant forms, may be their potentiation due to the formation of reactive iodine species. To this end, it is necessary to maintain the oxidation potential of iodine in the reducing medium, which is achieved by complexation with various bioorganic ligands [2].…”

“…Polyiodide is located inside the dextrin helix [4,14]. Peptides additionally coordinate iodine with their carboxyl groups, protecting it from molecules with more pronounced electron donor properties [2].…”

New Antituberculosis Drug FS-1

“…Really interesting are nanocomposites with molecular iodine, which are superior in their antimicrobial activity to the widely known complex of polyvinylpyrrolidone and iodine (PVP-iodine) [17,18]. The ability of molecular iodine to form complexes with a variety of properties and compositions with ligands of different nature makes it very promising to develop drugs based on iodine coordination compounds [19][20][21][22][23][24].…”

“…Such a structure protects I 2 from interaction with bioorganic compounds after oral intake. Bioorganic compounds are only able to compete with I 2 in complexing if donor activity is greater as against amide groups [24][25][26].…”