Effect of β-Cyclodextrin Complexation on Solubility and Enzymatic Conversion of Naringin

Cui, Lili; Zhang, Zhenhai; Sun, E; Jia, Xiao Bin

doi:10.3390/ijms131114251

Cited by 67 publications

(28 citation statements)

References 26 publications

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“…It has been reported to possess antiapoptotic, antiosteoporosis, antiulcer, antioxidant, antiinflammatory, and anticarcinogenic properties (13-14). Emerging data indicate that naringin is involved in amelioration of hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats

Xianchu

Gong

et al. 2015

Metab Brain Dis

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Previous research has indicated that Diabetes is a high risk of learning and memory deficits. Puerarin, an isoflavonoid extracted from Kudzu roots, has been reported to possess antioxidant, anti-inflammatory, anti-apoptotic and anti-diabetic properties which are useful in the treatment of various diseases. Recently, Puerarin was found to have the effects on learning and memory performances in humans and animal models. However, up to now, there is no detailed evidence on the effect of Puerarin on diabetes-associated cognitive decline (DACD). In this study, we designed to assess the effects of Puerarin on diabetes-associated cognitive decline (DACD) using a streptozotocin (STZ)-injected rat model and exploring its potential mechanism. Diabetic rats were treated with Puerarin (100 mg/kg per d) for 7 days. The learning and memory function was evaluated by morris water maze test. The acetylcholinesterase (AChE), choline acetylase (ChAT), oxidative indicators [malondialdehyde (MDA) and superoxide dismutase (SOD)] and inflammatory cytokine (TNF-a, IL-1β and IL-6) were measured in hippocampus by using corresponding commercial kits. mRNA and Protein levels of Bcl-2 were analyzed by RT-PCR and Westernblot. The results showed that supplementation of Puerarin improved the learning and memory performances compared with the STZ group by the morris water maze test. In addition, Puerarin supplement significantly prevented AChE and MDA activities, increased ChAT and SOD activities, and alleviated the protein level of TNF-α, IL-1β and IL-6 in the hippocampus compared with the STZ group. Moreover, the pretreatment with Puerarin also significantly increased the Bcl-2 expression. It is concluded that Puerarin possesses neuroprotection to ameliorate cognitive deficits in streptozotocin-induced diabetic rats by anti-inflammatory, antioxidant and antiapototic effects.

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Section: Introductionmentioning

confidence: 99%

Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats

Xianchu

Gong

et al. 2015

Metab Brain Dis

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“…Recent epidemiological and dietary interventional studies, both in humans and animals, suggest that these flavonoids prevent and delay neurodegeneration, especially in aged-population cognitive dysfunction [9]. Naringin (Figure 1), a well-known flavanone glycoside of Citrus fruits, possesses antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, anti-osteoporosis and anti-carcinogenic properties [10,11]. Naringin has been reported to attenuate behavioral alterations and cognitive impairment in kainic acid-induced epilepsy models [12] and 3-nitropropionic acid-induced Huntington models [13].…”

Section: Introductionmentioning

confidence: 99%

Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer’s Disease

Wang

Yang

Zhang

et al. 2013

IJMS

105

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The Amyloid-β (Aβ)-induced impairment of hippocampal synaptic plasticity is an underlying mechanism of memory loss in the early stages of Alzheimer’s disease (AD) in human and mouse models. The inhibition of the calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation plays an important role in long-term memory. In this study, we isolated naringin from Pomelo peel (a Citrus species) and studied its effect on long-term memory in the APPswe/PS1dE9 transgenic mouse model of AD. Three-month-old APPswe/PS1dE9 transgenic mice were randomly assigned to a vehicle group, two naringin (either 50 or 100 mg/kg body weight/day) groups, or an Aricept (2 mg/kg body weight/day) group. After 16 weeks of treatment, we observed that treatment with naringin (100 mg/kg body weight/day) enhanced the autophosphorylation of CaMKII, increased the phosphorylation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor at a CaMKII-dependent site and improved long-term learning and memory ability. These findings suggest that the increase in CaMKII activity may be one of the mechanisms by which naringin improves long-term cognitive function in the APPswe/PS1dE9 transgenic mouse model of AD.

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“…There are studies that have found that the solubility of naringin is poor, which leads to low bioavailability and hinders further studies on its pharmacological actions [1]. At present, many investigations have sought to find some ways to increase the solubility of naringin to improve its bioavailability, which include the synthesis of naringin inclusion complexes, for instance, beta-cyclodextrin (β-CD) complexation could significantly increase the solubility of naringin [2], adding the flavonoids as a compatibilizer [3], and the preparation of an appropriate dosage form such as solid dispersion [4].…”

Section: Introductionmentioning

confidence: 98%