Effect ofPleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines

Choi, DuBok; Cha, Wol-Suk; Kang, Seong-Seung; Lee, Byoung-Rai

doi:10.1007/bf02933057

Cited by 33 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Liquid fermentation of Lentinus squarrosulus mushroom produces high amounts of uniform mycelia biomass in the culture broth which was found as source of polysaccharide [2]. Previous research reported that batch cultures using Pleurotus ferulae, Pleurotus nebrodensis, and Agrocybe aegerita effectively produced polysaccharides and mycelia growth from liquid cultures [3]- [7]. It is also reported that Auricularia auricular judae, Pleurotus squarrosulus and Russula sp.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture

Ahmad¹,

Muniandy²,

Shukri³

et al. 2014

ABB

View full text Add to dashboard Cite

Various crude extracts of Lentinus squarrosulus mushroom mycelium and culture broth were prepared for antioxidant studies, glucan and carbohydrate compound analysis. Crude extract from ethanol, cold and hot water extraction was tested on several complementary test systems namely DPPH free radical scavenging, β-carotene linoleic acid oxidation, total phenolic compound, total flavonoid compound, total carbohydrate content and total glucan compositions. The antioxidant activity of the crude extracts of Lentinus squarrosulus mushroom mycelium and culture broth was determined by 2,2' diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method and β-carotene linoleic acid assay. Crude extracted from culture broth EPS EE recorded the highest radical scavenging effects at 20 mg/mL (85%) which is closer to the control antioxidants (ascorbic acid 97%; BHT 92.4%; BHA 93.6%). Both the ethanol extract (IPS EE and EPS EE) exhibited the highest β-carotene linoleic acid oxidation by recording IC50 values of 0.6 and 0.65 mg/mL respectively. IPS EE (0.59 mg/g) and EPS WE (0.58 mg/g) showed high flavonoid content whereas total phenol content was high in EPS WE (0.85 mg/g) and IPS EE (0.84 mg/g). Total carbohydrate concentrations were high in IPS HWE and IPS CWE with 19.1 and 16.3 mg/mL respectively and these data correlate with the β-glucan content in both extracts. The highest β-glucan content found in IPS CWE and IPS HWE were 12.2 and 11.4% w/w respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture

Ahmad¹,

Muniandy²,

Shukri³

et al. 2014

ABB

View full text Add to dashboard Cite

show abstract

“…The mediated antitumor activity against sarcoma, S-180, extracted from the fruiting body of polyporaceae family [71] due to the presence of $-D-glucan [72]. Extracts of Pleurotus species had higher antitumor activity toward lung cancer cells (A549).…”

Section: Antitumor Activitymentioning

confidence: 99%

Oyster Mushroom : Answer to Human Ailments:a Review

Jandaik¹,

Sharma²

2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Oyster mushroom is consumed all over the world due to its taste, flavor, high nutritional value, and some medicinal properties. Many species of this genus are rich in proteins with essential amino acids, polysaccharides, essential amino acids, dietary fibers, important minerals, and some vitamins. Because of this nutritional composition and presence of bioactive molecules, oyster mushroom has been reported to have anticancer, antihypertensive, antihypercholestromic, antidiabetic, antiobesity, antiaging, antimicrobial, and antioxidant activities. The high nutritional value and potent medicinal uses suggest that Pleurotus mushrooms are important functional foods or nutraceuticals.

show abstract

“…β-glucans from various fungi are not digested by human enzymes when orally administered, but instead are taken up in the small intestine, which stimulates mucosal and systemic immunity [74]. Uptake of β-glucans stimulates antitumor activities as well as protective activities against fungal and bacterial infections in animals and human.…”

Section: β-Glucan As Immunotherapy From Pleurotus Speciesmentioning

confidence: 99%

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

View full text Add to dashboard Cite

Abstract:In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of Bcells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

show abstract

Effect ofPleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines

Cited by 33 publications

References 14 publications

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture

Oyster Mushroom : Answer to Human Ailments:a Review

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Contact Info

Product

Resources

About

Effect ofPleurotus ferulae extracts on viability of human lung cancer and cervical cancer cell lines

Cited by 33 publications

References 14 publications

Antioxidant Properties and Glucan Compositions of Various Crude Extract from &lt;i&gt;Lentinus squarrosulus&lt;/i&gt; Mycelial Culture

Antioxidant Properties and Glucan Compositions of Various Crude Extract from &lt;i&gt;Lentinus squarrosulus&lt;/i&gt; Mycelial Culture

Oyster Mushroom : Answer to Human Ailments:a Review

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Contact Info

Product

Resources

About

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture

Antioxidant Properties and Glucan Compositions of Various Crude Extract from <i>Lentinus squarrosulus</i> Mycelial Culture