2014
DOI: 10.1007/s13197-014-1387-6
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Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4'-dimethyl ether isolated from Piper longum L

Abstract: Piper longum L. (Family: Piperaceae), is a widely used herb in several Ayurvedic formulations prescribed for various diseases. Potential of the plant material as an antidiabetic and cardio protective agent has not been evaluated so far. In the study, we designed experiments to evaluate antioxidant, glucose uptake potential and lipid content regulating potential of extracts and compound from P. longum fruits. Solvent extracts from Piper longum fruits using hexane, ethyl acetate, methanol, 70 % methanol-water we… Show more

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Cited by 19 publications
(17 citation statements)
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“…Antioxidant activity is important in biological systems exposed to excess reactive species. For example, muscle cells cultured in the presence of an ROS inducer show reduced glucose uptake that is overcome upon treatment with antioxidant substances [ 45 , 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…Antioxidant activity is important in biological systems exposed to excess reactive species. For example, muscle cells cultured in the presence of an ROS inducer show reduced glucose uptake that is overcome upon treatment with antioxidant substances [ 45 , 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…In people with type II diabetes, insulin-induced stimulation of hepatic, muscle, and adipose tissue glucose uptake is impaired [32,33,34,35]. Among numerous structurally diverse natural products affecting glucose uptake [35,36,37,38,39,40,41,42,43,44,45], flavonoids are a predominant factor [36,37,38,39,40]. Among isolates 1 – 24 , compounds 1 – 3 are flavonol derivatives and quercetin ( 3 ) was identified in our study as the most active single component of purple I. batatas leaves.…”
Section: Resultsmentioning
confidence: 99%
“…Acacetin 7-methyl ether ( Figure 1 ) was identified as a potent and highly selective MAO-B inhibitory constituent of Turnera diffusa . Acacetin 7-methyl ether has also been isolated from a few other plants and showed antidiabetic, antiproliferative, and antioxidative activities [ 21 , 22 , 23 ]. MAO inhibitors, as well as oxidative stress reducers, have significantly contributed in the treatment of neurodegenerative disorders, including Parkinson’s disease [ 24 ].…”
Section: Discussionmentioning
confidence: 99%