Effective Control of Type 2 Diabetes through Antioxidant Defense by Edible Fruits of Diospyros peregrina

Abstract

The matured fruits of Diospyros peregrina are successfully employed by the traditional healers and local people of costal West Bengal, India for the treatment of diabetes. Present investigation was undertaken to evaluate the role of hydroalcoholic extract of D. peregrina (HDP) on type 2 diabetes as well as the augmented oxidative stresses associated with it. Oral administration of HDP at 25, 50 and 100 mg kg−1 body weight per day to diabetic rats was found to possess significant dose-dependent hypoglycemic and hypolipidemic activity. The diabetic rats showed lower activities of superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) content in hepatic and renal tissues as compared to normal rats. The activities of SOD, CAT and GSH were found to be increased in extract-treated diabetic rats in selected tissues. The increased level of lipid peroxidation (thiobarbituric acid reactive substances) in diabetic rats was also found to be reverted back to near normal status in extract-treated groups. Thus it may be concluded that the HDP may produce its hypoglycemic effect through antioxidant defense mechanism.

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

“…In consistence with these findings, previous studies demonstrated significant increase in plasma creatinine and BUN [32][33][34] and serum urea levels [35] in diabetic rats compared to normal. The elevation of serum creatinine, uric acid, urea and UAE are reflection to impairment of kidney functions with development of diabetic nephropathy and loss of glomerular membrane permeability [36].…”

Determination of In Vitro Antioxidant Properties, Anti-inflammatory Effects and A-Amylase Inhibition of Purple Sea Urchin Extract of Echinometra mathaei from the Persian Gulf

“…As the review of literature reveals, it is the first time that the inhibition of α-amylase by these extracts has been reported. The results of the present study demonstrate that delayed starch hydrolysis by inhibition of α-amylase leads to the decline of these extracts in the glucose concentration (21).…”

Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F. Muell

“…Recent studies show that majority of the plasma antioxidants are depleted in type 2 diabetes patients [24] . It has been suggested from the ESR studies that patients with diabetes mellitus are susceptible to higher levels of oxidative stress [25] .…”