Effective loading of cisplatin into a nanoscale UiO-66 metal–organic framework with preformed defects

Lin, Shi Xin; Pan, Wei; Niu, Ru Jie; Liu, Yan; Chen, Jin Xiang; Zhang, Wen Hua; Lang, Jian‐Ping; Young, David J.

doi:10.1039/c9dt00719a

Cited by 55 publications

(23 citation statements)

References 66 publications

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“…Water-stable MOFs can be constructed with zwitterionic carboxylate ligands ( Yang et al, 2015 ) or zwitterionic thiolate ( Li et al, 2016 ) and some metal ions including Zr 4+ ( Cavka et al, 2008 ) and Zn 2+ ( Zhao et al, 2016a ). What's more, the instability of MOF in complex physiological environments should also be taken seriously ( Lin et al, 2019 ; Velasquez-Hernandez et al, 2019 ), and the water-stable MOFs can be obtained by doping metal ions ( Zhu et al, 2016 ). For example, small amounts of second metals (Zn 2+ , Ca 2+ , Mg 2+ , and Mn 2+ ) can be incorporated into metal clusters to enhance the stability of MIL-100 (Fe) ( Al Haydar et al, 2019 ).…”

Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…This conclusion was consistent with the study of Zhang and coworkers. [ 71 ] They prepared UiO‐66(Zr) for the storage of cisplatin prodrug. Triggered by the competitive coordination of phosphate anions to Zr 6 clusters, burst release of cisplatin in PBS was observed, with half payload release in less than 1 h. These studies verified that the controlled drug release could be intelligently triggered by phosphate anions through competitive coordination.…”

Section: Nmofs‐based Platforms For Controlled Drug Deliverymentioning

confidence: 99%

“…To date, nMOFs have been widely reported for the delivery of various anticancer chemotherapeutic agents, including DOX, cisplatin, methotrexate, CPT, 5‐FU, and artemisinin. [ 30b,58,62a,66,71,77b,88 ]…”

Section: Nmofs‐based Platforms For Cancer Therapymentioning

confidence: 99%

Versatile Nanoscale Metal–Organic Frameworks (nMOFs): An Emerging 3D Nanoplatform for Drug Delivery and Therapeutic Applications

Wen

Quan

Niu

et al. 2021

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For decades, nanoscale metal–organic frameworks (nMOFs) have attracted extensive interest in biomedicine due to their distinct characteristics, including facile synthesis, porous interior, and tunable biocompatibility. With high porosity, versatile nMOFs allow for the facile encapsulation of various therapeutic agents with exceptionally high payloads. Constructed from metal ions and organic linkers through coordination bonds, nMOFs with plentiful functional groups enable the surface modification for active targeting and enhanced biocompatibility. This review outlines the up‐to‐date progresses on the exploration of nMOFs in the field of biomedicine. First, the classification and synthesis of nMOFs are discussed, followed by the concrete introduction of drug loading strategies of nMOFs and mechanisms of stimulation‐responsive drug release. Second, the smart designs of the nMOFs‐based platforms for anticancer and antibacterial treatment are summarized. Finally, the basic challenges faced by nMOFs research and the great potential of biomimetic nMOFs are presented. This review article affords an inspiring insight into the interdisciplinary research of nMOFs and their biomedical applications, which holds great expectation for their further clinical translation.

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“…The major challenges associated with MOF-based viral detection and diagnostic strategies are the detection limit, instability of some MOFs in aqueous medium and complex physiological environments, 64 , 109 biological toxicity of some metal ions in the MOFs and complex in vivo environment. 14 The detection limit of MOFs ranged from pM to nM and is not low enough to detect a low level of viruses in the clinical samples, hence may affect sensitivity.…”

Section: Prospective View Of Mofs As Biosensing Materials For Covid-19mentioning

confidence: 99%

Metal Organic Frameworks as Biosensing Materials for COVID-19

2021

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The novel coronavirus disease (COVID-19) pandemic outbreak is the most startling public health crises with attendant global socio-economic burden ever experienced in the twenty-first century. The level of devastation by this outbreak is such that highly impacted countries will take years to recover. Studies have shown that timely detection based on accelerated sample testing and accurate diagnosis are crucial steps to reducing or preventing the spread of any pandemic outbreak. In this opinionated review, the impacts of metal organic frameworks (MOFs) as a biosensor in a pandemic outbreak is investigated with reference to COVID-19. Biosensing technologies have been proven to be very effective in clinical analyses, especially in assessment of severe infectious diseases. Polymerase chain reactions (PCR, RT-PCR, CRISPR) - based test methods predominantly used for SARS-COV-2 diagnoses have serious limitations and the health scientists and researchers are urged to come up with a more robust and versatile system for solving diagnostic problem associated with the current and future pandemic outbreaks. MOFs, an emerging crystalline material with unique characteristics will serve as promising biosensing materials in a pandemic outbreak such as the one we are in. We hereby highlight the characteristics of MOFs and their sensing applications, potentials as biosensors in a pandemic outbreak and draw the attention of researchers to a new vista of research that needs immediate action.

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Effective loading of cisplatin into a nanoscale UiO-66 metal–organic framework with preformed defects

Abstract: A high cisplatin loading of 256.5 mg g−1 (Zr6 : Pt = 1.5 : 1) was achieved by creating defects in the nano-sized UiO-66 metal–organic framework.

Cited by 55 publications

References 66 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Versatile Nanoscale Metal–Organic Frameworks (nMOFs): An Emerging 3D Nanoplatform for Drug Delivery and Therapeutic Applications

Metal Organic Frameworks as Biosensing Materials for COVID-19

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