Effective performance of contrast enhanced SPACE imaging in clearly depicting the margin of pituitary adenoma

Wu, Yue; Wang, Jing; Yao, Zhenwei; Zhong, Yang; Ma, Zengyi; Wang, Yongfei

doi:10.1007/s11102-014-0599-0

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…However, the MWCS is a very thin dural layer and it is difficult to establish its involvement by tumors through MRI only [68]. Other sequences have been suggested as well, including VIBE [124], CE SPACE (contrast enhanced sampling perfection with application-optimized contrasts using different flip-angle evolutions) [125], and T1-weighted three-dimensional (3D) fast spin echo (FSE) [126].…”

Section: Radiological Technical Advancementsmentioning

confidence: 99%

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

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Invasiveness in pituitary adenomas has been defined and investigated from multiple perspectives, with varying results when its predictive value is considered. A systematic literature review, following PRISMA guidelines, was performed, searching PubMed and Scopus databases with terms that included molecular markers, histological, radiological, anatomical and surgical data on invasiveness of pituitary adenomas. The results showed that differing views are still present for anatomical aspects of the sellar region that are relevant to the concept of invasiveness; radiological and histological diagnoses are still limited, but might improve in the future, especially if they are related to surgical findings, which have become more accurate thanks to the introduction of the endoscope. The aim is to achieve a correct distinction between truly invasive pituitary adenomas from those that, in contrast, present with extension in the parasellar area through natural pathways. At present, diagnosis of invasiveness should be based on a comprehensive analysis of radiological, intra-operative and histological findings.

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Section: Radiological Technical Advancementsmentioning

confidence: 99%

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Serioli

Doglietto

Fiorindi

et al. 2019

Cancers

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“…In our previous study, we observed a statistically significant signal intensity increase of cavernous sinus (which contains venous plexus, relatively slow‐flowing blood) after contrast enhancement in T2‐SPACE images. But the signal intensity of the adenoma itself did not change obviously 9 . Hence, the postcontrast T2‐SPACE sequence could show better contrast between cavernous sinus and adenoma, which is located on the edge of the pituitary (adjacent to cavernous sinus) than noncontrast images.…”

Section: Discussionmentioning

confidence: 94%

“…Previous reports have described the advantage of the SPACE sequence of obtaining high spatial resolution images in patients with intracranial diseases. For example, contrast‐enhanced SPACE provides a clear demonstration of the edge of pituitary macroadenoma for evaluation of cavernous sinus invasion 9,13,14 . In addition, another study suggested that contrast‐enhanced SPACE sequence could provide more information for detection of microadenomas than conventional T1‐SE sequence; however, these previous studies did not include the histological and surgical data necessary to confirm the lesions 10 …”

Section: Discussionmentioning

confidence: 99%

“…Dynamic scanning during contrast administration has achieved increased sensitivity as compared with conventional postcontrast SE imaging. Previous reports have described the advantage of Sampling Perfection with Application‐optimized Contrasts using different flip angle Evolutions (SPACE) sequence to obtain high spatial resolution images in patients with macroadenomas and microadenomas of the pituitary gland 9,10 . As three‐dimensional imaging yields 3D volume data with isotropic information, it can minimize the partial volume effect between small lesions and surrounding tissues and acquire thinner section images in any plane 11 .…”

Section: Introductionmentioning

confidence: 99%

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Contrast‐enhanced 3D‐T2‐weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)‐secreting pituitary microadenomas

Cai

Rui

et al. 2021

Clinical Endocrinology

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Objective Cushing disease is a potentially fatal endocrine disorder caused by adrenocorticotropin (ACTH)‐secreting microadenomas in the pituitary gland. Accurate detection and localization of the adenomas is the key to clinical treatment. This study analysed the value of contrast‐enhanced Sampling Perfection with Application‐optimized Contrasts using different flip angle Evolutions (SPACE) sequence in magnetic resonance imaging (MRI) assessment of ACTH‐secreting pituitary microadenomas. Design and Patients We carried out a retrospective study in which 45 patients with ACTH‐secreting pituitary microadenomas were enrolled. Dynamic contrast‐enhanced (DCE) coronal T1‐SE sequence was performed. A contrast‐enhanced coronal SPACE sequence was added immediately after DCE MRI finished. Two independent observers assessed the tumour existence and location, then the results were compared with surgical findings. Results Twenty‐four lesions (53.3%) were detected by the DCE T1‐SE sequence alone, while 35 lesions (80.0%) were detected with the addition of contrast‐enhanced SPACE sequence. The sensitivity (58.5% vs. 85.3%; p < .05) and best diagnostic accuracy (62.0% vs. 84.4%; p < .05) were significantly better for addition with SPACE sequence than DCE‐SE images alone in detection of ACTH‐secreting pituitary microadenomas. For lesions <5 mm, the detected numbers were 4 (16.6%) versus 10 (27.8%) by DCE T1‐SE sequence and combined DCE T1‐SE with SPACE sequence. Conclusions A combination of contrast‐enhanced SPACE with DCE T1‐SE sequence could improve the detection of ACTH‐secreting pituitary microadenomas. Contrast‐enhanced SPACE sequence could be a supplementary sequence for imaging of ACTH‐secreting pituitary adenomas when T1‐SE sequence provides negative or equivocal findings.

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“…When based on the turbo spin echo (TSE) sequence, it avoids the susceptibility artifacts of the SGE sequence, whereas the minimum layer thickness can be of less than 1 mm when based on the 3D technique. 16 The different systems were studied in clinical applications, 17,18 including using the SPACE sequence for pituitary adenoma. 19,20 However, those previous studies did not obtain the clinical or histological data to confirm their diagnoses.…”

mentioning

confidence: 99%

Application of Contrast-Enhanced 3-Dimensional T2-Weighted Volume Isotropic Turbo Spin Echo Acquisition Sequence in the Diagnosis of Prolactin-Secreting Pituitary Microadenomas

Guo¹,

Guo³

et al. 2021

J Comput Assist Tomogr

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Objective: This study aimed to investigate the value of contrast-enhanced 3dimensional (3D) T2-weighted (T2W) Volume Isotropic Turbo Spin Echo Acquisition (VISTA) sequence in prolactin-secreting pituitary adenoma diagnosis. Methods:We enrolled 158 patients with hyperprolactinemia. Coronal dynamic contrast-enhanced (DCE) T1 spin echo and T2W VISTA sequences were performed. The detection of pituitary microadenomas in 3 imaging groups (DCE magnetic resonance imaging [MRI], VISTA, and DCE MRI + VISTA) were compared using McNemar test and χ 2 test. Results:The DCE MRI + VISTA group detected 28 more pituitary microlesions than DCE MRI alone. Among these, 20 lesions were clearly observed on VISTA images but were negative on DCE MRI. The combined sequences showed higher sensitivity (85.3%) and diagnostic accuracy (89.2%) for adenoma detection than any of the sequences alone ( P < 0.01). We noted that in 65.7% of the patients with adenoma (46 of 70), a "hypointense rim" was present around the lesion on the VISTA images. Of them, 11 patients underwent surgery. Histopathology confirmed that the "hypointense rim" was a pseudocapsular structure at the edge of the adenoma. Conclusions:For patients with hyperprolactinemia, the 3D T2W VISTA sequence is an important supplement to DCE MRI, because it could improve the detection rate of pituitary microadenomas.

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Effective performance of contrast enhanced SPACE imaging in clearly depicting the margin of pituitary adenoma

Abstract: CE SPACE could provide better contrast of pituitary adenoma with surrounding CS and clear demonstration of tumor edge for CS invasion evaluation than conventional CE T1-SE sequence.

Cited by 11 publications

References 14 publications

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Pituitary Adenomas and Invasiveness from Anatomo-Surgical, Radiological, and Histological Perspectives: A Systematic Literature Review

Contrast‐enhanced 3D‐T2‐weighted SPACE sequence for MRI detection and localization of adrenocorticotropin (ACTH)‐secreting pituitary microadenomas

Application of Contrast-Enhanced 3-Dimensional T2-Weighted Volume Isotropic Turbo Spin Echo Acquisition Sequence in the Diagnosis of Prolactin-Secreting Pituitary Microadenomas

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