Effectiveness evaluation of hemostatic materials in acute exposure &lt;i&gt;in vivo&lt;/i&gt;

Липатов, В. А.; Гаврилюк, В. П.; Северинов, Д. А.; Grigorian, Alla

doi:10.16931/10.16931/1995-5464.2021-2-137-143

Ann. hir. gepatol.

2021

DOI: 10.16931/10.16931/1995-5464.2021-2-137-143

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Effectiveness evaluation of hemostatic materials in acute exposure <i>in vivo</i>

В. А. Липатов

В. П. Гаврилюк

Д. А. Северинов

et al.

Abstract: Ýêñïåðèìåíòàëüíîå èññëåäîâàíèå / Experimental studyЦель исследования -сравнительная оценка эффективности гемостатических материалов в остром эксперименте in vivo. Материал и методы. Изучали образцы гемостатических материалов TachoComb (№1), Gelita-Spon Standard (№2), Surgicel Fibrillar (№3), образцы кровоостанавливающих губок, разработанные совместно с ООО "Линтекс" (Санкт-Петербург, Россия) на основе натрий-карбоксиметилцеллюлозы (Na-КМЦ): Na-КМЦ+Транексамовая кислота, прессованный (№4), Na-КМЦ+Транексамовая … Show more

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Cited by 2 publications

References 9 publications

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Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Terekhov,

Mishina,

Klyueva

et al. 2024

Innovacionnaâ medicina Kubani

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Objective: To study peculiarities of skin wound healing under ischemic conditions with topical treatment using a combination of benzalkonium chloride and dexpanthenol.Materials and methods: We conducted an experiment on a rat model of skin wound healing under ischemic conditions. Male Wistar rats were divided into 4 groups, with 30 rats in each group. Group 1 received no treatment; group 2 was treated with the Levomecol ointment; group 3 and group 4 were treated with benzalkonium chloride immobilized based on the carboxymethylcellulose sodium salt and a combination of benzalkonium chloride and dexpanthenol immobilized based on the carboxymethylcellulose sodium salt, respectively. We used planimetric and biochemical (alkaline phosphatase [ALP] level) methods, measured the pH of the wound surface and wound bed temperature, determined the hydroxyproline concentration in the wound defect tissues, and performed statistical processing of the data.Results: Group 4 had the largest percentage of wound surface area reduction and pH values. Thermometry on day 10 showed a decrease in wound temperature in groups 2 and 4, whereas groups 1 and 3 demonstrated maximum values. By the end of the experiment, group 4 had the maximum hydroxyproline concentration that was significantly higher than the amino acid content in groups 1, 2, and 3: 1.2, 1.1 and 1.1 times higher, respectively. Maximum ALP levels were observed on day 5 in group 4, whereas in groups 2 and 3 they were observed on day 8 and only on day 10 in group 1.Conclusions: Skin wound healing under ischemic conditions was faster in the group in which topical treatment involved a combination developed by us: benzalkonium chloride and dexpanthenol immobilized based on the carboxymethylcellulose sodium salt.

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Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Terekhov,

Mishina,

Klyueva

et al. 2024

Innovacionnaâ medicina Kubani

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Comparative analysis of efficacy of the new local hemostatic agents

Lipatov,

Lazarenko,

Severinov

et al. 2023

MES

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Various local hemostatics (based on collagen, gelatin, cellulose, etc.) are used to stop bleeding from parenchymal organs of the abdominal cavity. In the context of an acute in vivo experiment, this study aimed to comparatively assess the time and volume of bleeding from a trauma of abdominal cavity's parenchymal organs covered with a new collagen-based spongy hemostatics combined with Na-CMC. We used new multicomponent polymer sponge implants (MPSI) based on marine collagen and carboxymethyl cellulose sodium salt, Na-CMC; the components were mixed in the ratios of 15/85, 25/75, 50/50. Hemostatic activity of the samples was assessed by bleeding time and blood loss volume. For the experiments, rats underwent laparotomy and resection of the left lobe of liver (series 1) and lower pole of spleen (series 2). In both series of experiments, the controlled parameters (bleeding time and blood loss volume) were smallest in group 6, where the MPSI were 50/50 Na-CMC/collagen. The hypothesis of higher efficacy of composite local hemostatic agents (namely, made of Na-CMC and deep-sea squid collagen) in cases of trauma of the parenchymal organs was confirmed experimentally, and same experiment has also shown that collagen in the composition of MPSI boosts bleeding arrest (for liver injury, the smallest blood loss and hemorrhage control time was 41 s, for spleen injury — 57 s, respectively; p ≤ 0.05).

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Effectiveness evaluation of hemostatic materials in acute exposure <i>in vivo</i>

Cited by 2 publications

References 9 publications

Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Peculiarities of Skin Wound healing Under Ischemic Conditions With Topical Treatment Using a Combination of Benzalkonium Chloride and Dexpanthenol

Comparative analysis of efficacy of the new local hemostatic agents

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