“…Overall, 14 trials were deemed to be at high risk of bias, 23,24,26,29,30,32,34,36,37,42,45,[47][48][49] 14 as having some risk of bias, 21,22,25,27,28,31,33,[38][39][40][41]43,44,46 and only one as low risk of bias (Figure 2). 35 A high risk of bias was commonly identified with the methods of randomisation, lack of allocation concealment, inappropriate analyses, missing data, and uncertainty on the integrity of DROVANDI ET AL.…”