Effectiveness of absorption and passage through the small intestine, as a model of oral prolactin administration

Dolińska, Barbara; Siemiradzka, Wioletta; Ryszka, Florian

doi:10.1016/j.biopha.2019.109515

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Stress activates microglia and mast cells by releasing neuropeptide neurotensin and corticotropin-releasing hormone. Exacerbation of multiple sclerosis as a result of stress may be caused by dysfunction of the hypothalamic-pituitary-adrenal axis (HPA) due to decreased through the small intestine of sucking piglets is possible and it depends prolactin concentrations and the other agents (trehaloza) [22]. It has also been reported that large molecular weight peptide substances such as insulin, corticotropin, prolactin and albumin penetrate the pericardium [23].…”

Section: Introductionmentioning

confidence: 99%

“…The transdermal route of administration of therapeutic substances allows obtaining a therapeutic effect bypassing the gastrointestinal tract, where it may be inactivated (e.g., protein-peptide substances) and is also much cheaper and painless There are reports of penetration and absorption of peptide substances by natural membranes. It has been demonstrated that the absorption and penetration of prolactin through the small intestine of sucking piglets is possible and it depends prolactin concentrations and the other agents (trehaloza) [ 22 ]. It has also been reported that large molecular weight peptide substances such as insulin, corticotropin, prolactin and albumin penetrate the pericardium [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Concentration on Release and Permeation Process of Model Peptide Substance-Corticotropin-From Semisolid Formulations

2020

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The transdermal route of administration of drug substances allows clinicians to obtain a therapeutic effect bypassing the gastrointestinal tract, where the active substance could be inactivated. The hormonal substance used in the study-corticotropin (ACTH)-shows systemic effects. Therefore, the study of the effect of the type of ointment base and drug concentration on the release rate and also permeation rate in in vivo simulated conditions may be a valuable source of information for clinical trials to effectively optimize corticotropin treatment. This goal was achieved by preparation ointment formulation selecting the appropriate ointment base and determining the effect of ACTH concentration on the release and permeation studies of the ACTH. Semi-solid preparations containing ACTH were prepared using Unguator CITO e/s. The release study of ACTH was tested using a modified USP apparatus 2 with Enhancer cells. The permeation study was conducted with vertical Franz cells. Rheograms of hydrogels were made with the use of a universal rotational rheometer. The dependence of the amount of released and permeated hormone on the ointment concentration was found. Based on the test of ACTH release from semi-solid formulations and evaluation of rheological parameters, it was found that glycerol ointment is the most favourable base for ACTH. The ACTH release and permeation process depends on both viscosity and ACTH concentration. The higher the hormone concentration, the higher the amount of released ACTH but it reduces the amount of ACTH penetrating through porcine skin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Concentration on Release and Permeation Process of Model Peptide Substance-Corticotropin-From Semisolid Formulations

2020

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“…It was found that the absorption of PRL in the small intestine of the suckling piglet was significantly dependent on the concentration of the hormone and trehalose in solution. In turn, the permeation process of PRL in the studied range is influenced by all studied factors (hormone concentration, trehalose and mannitol concentration, pH value of the solution) [51].…”

Section: Discussionmentioning

confidence: 99%

Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

2021

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(1) Background: Skin is a difficult barrier to overcome, especially for molecules with masses greater than 500 Da. It has been suggested that albumin may contribute to more effective penetration of many therapeutic substances. In this study, an attempt was made to use albumin in semi-solid formulations to increase the skin penetration of another peptide—corticotropin (ACTH). (2) Methods: Hydrogels were prepared at two concentrations: 15 mg/g and 20 mg/g corticotropin, then albumin was added to them in different stoichiometric ratios. The degree of ACTH release from hydrogels, both with and without albumin addition, was investigated. For selected hydrogels the process of corticotropin permeation through a model membrane, i.e., pig skin, was examined. (3) Results: The study of corticotropin release showed that the addition of albumin, depending on its amount, may delay or increase the release process. Similarly, a study of ACTH permeation through porcine skin showed that albumin can delay or increase and accelerate ACTH permeation. (4) Conclusions: Hydrogel, applicated on the skin surface, may prove to be a beneficial and convenient solution for patients. It is an innovative way of application ACTH that bypasses the gastrointestinal tract and may result in increased availability of the peptide and its efficacy.

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“…The receptor compartment was equipped by heating jacket with a heating circulator and a sample port to allow sample to be taken out at certain time intervals. The picture is adopted from the work Dolinska et al 31) with permission. Modification was conducted referring to the work of Nunes and co-workers 37) .…”

Section: Surface Ph Measurementmentioning

confidence: 99%

“…The in vitro protein release from the buccal membrane was carried out in a modified Franz diffusion cell using synthetic membrane (cellophane) 31,32) , as described in Fig. 3.…”

Section: In Vitro Release Studymentioning

confidence: 99%

Induction of protein specific antibody by carbonated hydroxy apatite as a candidate for mucosal vaccine adjuvant

et al. 2022

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Buccal mucosae are considered as a site for vaccine delivery since they are relatively abundant with antigen-presenting dendritic cells, mainly Langerhans cells. In this study, we formulated carbonated hydroxy apatite (CHA) with ovalbumin (OVA) (denoted as CHA-OVA), incorporated it into bilayer buccal membrane to form hydrogel films containing CHA-OVA complex for vaccination via buccal mucosae. Ethylcellulose blend with polyethylene glycol 400 were used as impermeable backing layer. Physical properties of all tested buccal membranes were found suitable for mucosal application. In vitro and ex vivo release study showed there was no burst release of OVA found from all tested formula. From the in vivo examination, rabbit buccal mucosae vaccinated by mucoadhesive membranes containing CHA-OVA complex demonstrated mucosal specific antibody induction, represented the potential of CHA as a candidate of needle-free vaccine adjuvant. Future research is awaiting to investigate proper CHA crystallinity in complex with protein against targeted diseases.

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Effectiveness of absorption and passage through the small intestine, as a model of oral prolactin administration

Cited by 6 publications

References 25 publications

Influence of Concentration on Release and Permeation Process of Model Peptide Substance-Corticotropin-From Semisolid Formulations

Influence of Concentration on Release and Permeation Process of Model Peptide Substance-Corticotropin-From Semisolid Formulations

Modelling and Control of Corticotropin Permeation from Hydrogels across a Natural Membrane in the Presence of Albumin

Induction of protein specific antibody by carbonated hydroxy apatite as a candidate for mucosal vaccine adjuvant

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