Effectiveness of Autogenous Tooth Bone Graft Combined with Growth Factor: Prospective Cohort Study

Ahn, Kyo-Jin; Kim, Young-Kyun; Yun, Pil‐Young; Lee, Bu-Kyu

doi:10.5856/jkds.2013.6.2.50

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…A prospective study was conducted to evaluate the bone healing effect and clinical capabilities like bone healing ability of autogenous tooth bone materials as a scaffold when used together with growth factor in patients with alveolar deficient sites for implant placement [35].…”

Section: Osteoinductivity and Osteo Conductivity Of Teethmentioning

confidence: 99%

Autogenous Tooth Bone Graft - A Biomimetic Promise for Regenerative Dentistry

Bhalla¹,

Patil²,

Belludi³

et al. 2019

Act Scie Dental

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Regeneration is defined as reconstitution of a lost or injured part, with form and function of lost structures restored. Graft associated regeneration still remains the mainstay and newer graft materials of diverse origin are added to the already existing lot, with claims of superior clinical outcomes. Thus, the search for newer, near ideal biomaterials and procedures continue to be a challenge in the field of regenerative dentistry. Based on the regenerative properties of osteoconduction, osteoinduction, creeping substitution and osteogenesis mediated via the expression of growth factors derived from the patient's own tooth and the histo-morphological similarities between tooth and bone, a novel bone graft material has been developed utilizing the structural components of an extracted tooth. This review elaborately describes a novel regenerative technology of the autogenous tooth derived bone graft material, a biomimetic system that treats patients by fabricating a bone graft material from their own extracted teeth.

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Section: Osteoinductivity and Osteo Conductivity Of Teethmentioning

confidence: 99%

Autogenous Tooth Bone Graft - A Biomimetic Promise for Regenerative Dentistry

Bhalla¹,

Patil²,

Belludi³

et al. 2019

Act Scie Dental

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“…Therefore, DDM is considered competent enough as a bone regeneration and replacement material. 10 11…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, DDM is considered competent enough as a bone regeneration and replacement material. 10,11 Based on the above explanation, this study aimed to determine the characteristics of demineralized dentin material sponge (DDMS). Fourier transform infrared (FTIR) test was performed to determine the characteristics and the components contained in the materials through functional groups.…”

Section: Introductionmentioning

confidence: 99%

The Characteristics of Demineralized Dentin Material Sponge as Guided Bone Regeneration Based on the FTIR and SEM-EDX Tests

et al. 2022

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Objective The objective of this study was to determine the characteristics of demineralized dentin material sponge (DDMS). Material and Methods An observational study was conducted on DDMS and BPCM. Fourier transform infrared (FTIR) test was performed to determine the characterizations of the materials. Scanning electron microscope-electron dispersive X-ray spectroscopy (SEM-EDX) test was performed to observe the elements contained in the materials. Results The infrared spectrum of the DDMS and BPCM functional groups showed the same pattern in each variation, and no significant differences were found. According to SEM analysis, the cavities that make up the membrane were spotted on the surface. Besides, according to the SEM-EDX analysis, DDMS contained chlorine, carbon, and calcium, while BPCM contained carbon, oxygen, and sulfur. Conclusion DDMS has the potential to be a biomaterial for bone tissue engineering in terms of the characteristics. DDMS had a structure that almost resembles BPCM as seen from the results of the FTIR graph between DDMS and BPCM. The morphological structure of the two materials in the SEM test appeared to have porosity with various sizes.

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“…2,4,5 DDM can play an important role as scaffold because it contains both organic and inorganic components in addition to being microporous. 6 Ideally, scaffold must be biocompatible, biodegradable and non-toxic. Moreover,…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity test and characteristics of demineralized dentin matrix scaffolds in adipose-derived mesenchymal stem cells of rats

Sari¹,

Maduratna²,

Ferdiansyah³

et al. 2018

Dent. J.

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Background: Demineralized dentin matrix (DDM) scaffold is a substitute material for the bone contained in human teeth. DDM is a scaffold-derived tooth dentine containing type I collagen and bone morphogenetic protein (BMP). While DDM possesses the ability to perform osteoinductive and osteoconductive roles, a cytotoxicity test of DDM scaffold remains extremely important in evaluating the level of toxicity of a material if cultured in cells. Adipose-derived mesenchymal stem cells (ADMSCs) are multipotent in nature because they contain progenitor cells and have the potential for differentiation via adipogenic, osteogenic and chondrogenic pathways. ADMSCs are also known to have high biocompatibility and the ability to combine with other bone material. Purpose: The purpose of this study was to determine the cytotoxicity and characteristics of DDM scaffolds derived from bovine teeth in the ADMSCs of rats cultured in vitro. Methods: This research constituted an experimental study. ADMSCs were isolated from the inguinal fat of rats. Thereafter, DDM was extracted from bovine teeth and formed 355-710 μm-sized particles. DDM scaffolds were assessed using SEM and the effects of DDM scaffolds on the cell viability of ADMSCs at concentrations of 10%, 50%, and 100% analyzed by means of 3-4,5’dimethylihiazol-2-yl,2.5-di-phenyl-tetrazolium bromide (MTT) assay. The results obtained were then analyzed by an ANOVA to establish the difference between the groups. Results: SEM results showed the diameter sizes of the dental tubulis DDM scaffolds to be approximately 4.429 μm and 7.519 μm. The highest cell viability (97.08%) was found by means of an MTT test to be in ADMSCs at a concentration of 10% compared to those at concentrations of 50% and 100%. Conclusion: In conclusion, DDM scaffold derived from bovine teeth with a particle size of 355-710 μm produces a low cytotoxicity effect on ADMSCs.

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Effectiveness of Autogenous Tooth Bone Graft Combined with Growth Factor: Prospective Cohort Study

Cited by 4 publications

References 23 publications

Autogenous Tooth Bone Graft - A Biomimetic Promise for Regenerative Dentistry

Autogenous Tooth Bone Graft - A Biomimetic Promise for Regenerative Dentistry

The Characteristics of Demineralized Dentin Material Sponge as Guided Bone Regeneration Based on the FTIR and SEM-EDX Tests

Cytotoxicity test and characteristics of demineralized dentin matrix scaffolds in adipose-derived mesenchymal stem cells of rats

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