2020
DOI: 10.3390/cells9102241
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Effectiveness of Autologous Platelet Concentrates in Management of Young Immature Necrotic Permanent Teeth—A Systematic Review and Meta-Analysis

Abstract: The use of autologous platelet concentrates (APCs) in regenerative endodontic procedures is inconsistent and unclear. The aim of this meta-analysis was to evaluate the effectiveness of autologous platelet concentrates compared to traditional blood-clot regeneration for the management of young, immature, necrotic, permanent teeth. The digital databases MEDLINE, SCOPUS, CENTRAL, Web of Science, and EMBASE were searched to identify ten randomized clinical trials. The outcomes at postoperative follow-up, such as d… Show more

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Cited by 30 publications
(37 citation statements)
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“…Overall, twenty SRs without meta-analysis [ 4 , 5 , 6 , 7 , 8 , 9 , 12 , 13 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] and nine SRs with meta-analysis were included [ 10 , 11 , 14 , 15 , 34 , 35 , 36 , 37 , 38 ] ( Table 1 ). Multiple sub-topics were investigated, such as REP protocols and outcomes [ 4 , 5 , 7 , 9 , 11 , 12 , 13 , 14 , 15 , 22 , 27 , 29 , 36 ], solely REP protocols [ 30 , 37 ], solely outcomes [ 6 , 8 , 10 , 23 , 28 , 38 ], and stem cells on REP [ 24 , 25 , ...…”
Section: Resultsmentioning
confidence: 99%
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“…Overall, twenty SRs without meta-analysis [ 4 , 5 , 6 , 7 , 8 , 9 , 12 , 13 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] and nine SRs with meta-analysis were included [ 10 , 11 , 14 , 15 , 34 , 35 , 36 , 37 , 38 ] ( Table 1 ). Multiple sub-topics were investigated, such as REP protocols and outcomes [ 4 , 5 , 7 , 9 , 11 , 12 , 13 , 14 , 15 , 22 , 27 , 29 , 36 ], solely REP protocols [ 30 , 37 ], solely outcomes [ 6 , 8 , 10 , 23 , 28 , 38 ], and stem cells on REP [ 24 , 25 , ...…”
Section: Resultsmentioning
confidence: 99%
“…Six SRs failed to report a defined timeframe [ 6 , 9 , 14 , 26 , 28 , 31 ]. Seven SRs did not report language restrictions [ 11 , 22 , 23 , 31 , 33 , 35 , 38 ], twelve applied a language restriction as an inclusion criterion [ 8 , 10 , 12 , 13 , 14 , 15 , 24 , 26 , 28 , 29 , 32 , 36 , 37 ], and the remaining had no language restriction [ 4 , 5 , 6 , 7 , 9 , 25 , 27 , 30 , 34 ].…”
Section: Resultsmentioning
confidence: 99%
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