Effectiveness of Bailing capsules in the treatment of lupus nephritis: A meta‑analysis

Abstract

Previous studies have explored the treatment of lupus nephritis with Bailing capsules; however, due to limited sample sizes and inconsistent results across these studies, no definitive conclusions have been drawn. Thus, the present study aimed to provide evidence for the effectiveness of Bailing capsules in the treatment of lupus nephritis. To obtain relevant clinical studies (published before 20 July 2019), PubMed, embase, cochrane library, china national Knowledge infrastructure, WanFang and the chinese Biomedical literature database were searched, and relevant studies concerning the use of Bailing capsules for treating lupus nephritis were selected. The extracted data were general characteristics such as the first author, publication year, study year, follow-up time, age, sex, course of the disease and a number of outcome indicators. These included systemic lupus erythematosus disease activity index (Sledai) score, serum albumin (alb), 24-h urinary protein, serum creatinine, anti-ds-dnaigM, complement component 3 (c3), and the number of effective treatments and complications. Meta-analysis was performed using r-3.12 software. Publication bias was assessed using egger's test. a total of 14 studies comprising 1,301 participants were combined for analysis in the present study. The results demonstrated that with the exception of anti-ds-dnaigM and complement c3, other indicators, such as Sledai score, alb, 24-h urinary protein, serum creatinine, and the number of effective treatments and complications) in the Bailing capsule treatment group were improved compared with those in the control group. The results of the present meta-analysis suggested that Bailing capsules may be effective in the treatment of lupus nephritis.

Discussion on machine learning technology to predict tacrolimus blood concentration in patients with nephrotic syndrome and membranous nephropathy in real-world settings

“…Previous studies have focused on the effect of TAC combined with other drugs [ 16 , 17 ], but did not evaluate the effect of the combination on blood TAC concentration. Our study showed that the combination of Bailing and Huangkui with TAC affects blood TAC concentration.…”

A Review of the Potential Benefits of Herbal Medicines, Small Molecules of Natural Sources, and Supplements for Health Promotion in Lupus Conditions

“…Several semi-synthetic derivatives of artemisinin with greater solubility or bioactivity, such as dihydroartemisinin, artemether, and arteether, artesunate have been developed and investigated in several research works [140,141]. Along with its anti-malarial effect, artemisinin and its derivatives have exhibited anti-inflammatory, immunoregulatory, and antioxidant properties [142]. Like some other conventional anti-malarial drugs, including chloroquine and hydroxychloroquine, artemisinin derivatives are assumed to have beneficial therapeutic effects on SLE [143,144].…”

Application of herbal traditional Chinese medicine in the treatment of lupus nephritis

“…In the TCM theory, C. sinensis has the functions of invigorating the kidneys, improving lung function, and enhancing the original qi . It has been suggested that C. sinensis regulates the immune system bidirectionally, reduces tubulointerstitial damage, inhibits renal fibrosis, and improves renal functions ( Barido et al, 2020 ; Li et al, 2020 ). In six randomized controlled trials with treatment duration of 2–12 months, the effects of C. sinensis were tested on a total of 507 LN patients ( Li et al, 2006 ; Davidson et al, 2019 ; Ren et al, 2019 ; Yu et al, 2021b ).…”