Effectiveness of Boiled  Cherry Leaf (muntingia calabura L) and Figs Leaves (Ficus Carica) Toward SGOT SGPT Serum of Male Wistar Strain Rats with Acute Hepatitis Models

Lalihatu, Merza Rivano; Sudharmono, Untung

doi:10.35974/isc.v7i1.2076

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Kersen leaves contain various phytochemicals including saponins, flavonoids, tannins. Flavonoids contained in Kersen leaves have kersen leaf extract administration can reduce levels of ALT / SGPT, AST/SGOT enzymes (Lalihatu & Sudharmono, 2019;Zakaria et al, 2018). Flavonoids as antioxidants have hepatoprotective activity in the concentration range of 1-100 g/mL increasing cell viability and inhibiting cellular leakage of hepatocytes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (Kočevar et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Administration of kersen leaf extract can improve proximal renal tubules in diabetic rats (Safrida & Sabri, 2019). Research by Lalihatu et al, 2019, Kersen leaf decoction can reduce SGOT and SGPT levels in Wistar Rats with Acute Hepatitis (Lalihatu & Sudharmono, 2019). Kersen leaves have a variety of activities including antimicrobial, anti-inflammatory, antinociseptic, anticancer, antiulcer, antioxidant and gastroprotektic (Mahmood et al, 2014;Pereira et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Kersen Leaf Tea’s Effects on Male Mice’s Liver and Kidney Functions Induced by Alloxan

Wiyadi¹,

Mustaming²,

Andraini³

2022

IJOMS

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Kersen leaf is a tree native to Southern America and Southern Mexico. In Indonesia, this tree is very easy to get because it grows a lot on the side of the streets. Empirically, Kersen leaves have been widely used by the public as one of the herbs or herbs to overcome various diseases, including DM disease. The study used True Experimental design with Pre and post Control Design design. The purpose of this study was to test the effect of using Kersen Leaf Tea on Hepar and Kidney function. Hepar function will be measured by assessing levels of Alanain Transminerase (ALT) Aspartate aminotransferases (AST). For kidney function is assessed by measuring Creatinine and Ureum levels. The results of the Shapiro test normality test obtained data that were not normally distributed so that the Bivariate test used alternative tests, namely the Kruscal Walis test and the Wilcoxon Test. The results of the study on the administration of kersen leaf tea there were differences between the Control group with the dose group of 2%, dose 4% and dose 6% at ALT levels (p = 0.000), AST levels (p = 0.005), and creatinine levels (p = 0.007) but there was no difference in Urium (P = 0.447). The results of the Wilcoxon test showed the effect of giving kersen leaf tea on ALT levels ( p = 0.018), AST levels (p = 0.000), Urium levels (p = 0.37) and creatinine levels (p = 0.038). The administration of kersen leaf tea improves liver and kidney function in Alloxan-induced male mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kersen Leaf Tea’s Effects on Male Mice’s Liver and Kidney Functions Induced by Alloxan

Wiyadi¹,

Mustaming²,

Andraini³

2022

IJOMS

View full text Add to dashboard Cite

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Hepatoprotective Effect of Alcoholic Extract of Ficus carica Leaves ‎Against ‎‎Cypermethrin-Induced Liver Toxicity in Male Albino Rats

Ismael Abbasa,

JM Jawad

2023

Iraqi J. Vet. Med.

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Cypermethrin (CYP), a synthetic pyrethroid, is recognized for its insecticidal properties but ‎poses potential risks of hepatotoxicity. In traditional medicine, Ficus (F.) carica (common ‎fig) leaves have historically been used for various therapeutic applications. This study ‎aimed to evaluate the hepatoprotective effect of the methanolic extract of F. carica‎‎ leaves ‎against CYP-induced liver damage in adult male albino rats (Rattus norvegicus). The ‎animals (n=30), 8-12 weeks old ‎and weighing 200-250 g‎, were randomly divided into five ‎experimental groups (n=6) and treated as follows: the negative control group received ‎distilled water; the CYP-Only group was exposed to 4.74 mg/kg BW for 45 days; the ‎CYP+post-treatment group received the same CYP dosage followed by F. carica‎‎ methanolic ‎leaf extract at 500 mg/kg BW orally for two weeks; the pre-treatment+CYP group received ‎ ‎F. carica‎‎ methanolic leaf extract at 500 mg/kg BW orally for two weeks followed by CYP ‎exposure for 45 days; and the F. carica‎‎ extract-Only group was administered the methanolic ‎leaf extract at 500 mg/kg BW orally for two weeks. At the end of the experiment, serum and ‎liver samples were analyzed for biochemical and histopathological changes. CYP-Only ‎exposed group showed significantly increased serum alanine aminotransferase (ALT) and ‎alkaline phosphatase (ALP) and caspase-3 levels (P<0.05). Histopathological examination ‎in group exposed CYP only revealed liver damages as evidenced by central vein congestion, ‎scattered perivascular mononuclear cell infiltration, prominence of ‎Kupffer cells, nuclear ‎pyknosis, and severe hepatocytic necrosis. Treatment with F. carica‎‎ leaf extract, either ‎before or after CYP exposure, as well as solely with F. carica‎‎ leaf ‎‎extract, ameliorated both ‎the biochemical and histological indices of liver ‎damage. The findings suggest that the ‎methanolic extract of F. carica‎‎ leaves provides promising hepatoprotective effects against ‎CYP-induced liver damage in albino rats, likely via its antioxidative properties‎‎.

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Effectiveness of Boiled Cherry Leaf (muntingia calabura L) and Figs Leaves (Ficus Carica) Toward SGOT SGPT Serum of Male Wistar Strain Rats with Acute Hepatitis Models

Cited by 2 publications

References 6 publications

Kersen Leaf Tea’s Effects on Male Mice’s Liver and Kidney Functions Induced by Alloxan

Kersen Leaf Tea’s Effects on Male Mice’s Liver and Kidney Functions Induced by Alloxan

Hepatoprotective Effect of Alcoholic Extract of Ficus carica Leaves ‎Against ‎‎Cypermethrin-Induced Liver Toxicity in Male Albino Rats

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