Physical education (PE) contributes to promoting students’ cognitive development. Integrating core academic subjects into PE classes may provide numerous benefits in both cognitive and physical developments. Therefore, combining cognitive learnings of other core subjects with physical activities may increase students’ academic learning time while improving physical abilities and skills in PE classes. EDUball/BRAINball is an interdisciplinary concept that uses balls with letters and numbers to merge physical activities with various school subjects such as mathematics and languages, especially for students up to 12 years old. The pedagogical approach has been developed for over twenty years, and students who participated in it showed significant improvements in literacy, numeracy, and physical performance. Given its potential, the EDUball/BRAINball approach offers a great didactic and pedagogical alternative for teaching fundamental subjects within PE classes. This should be considered by PE teachers, who should have access and training to implement these activities in PE classes.