Effectiveness of different methods for polypectomy in the menopause: a retrospective study

Molnár, Szabolcs; Farkas, Zsolt; Jakab, Attila; Lampé, Rudolf; Török, Péter

doi:10.1080/13697137.2020.1732915

Cited by 3 publications

(3 citation statements)

References 34 publications

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“…In addition, the recurrence rate of EPs by curettage is high, mainly because simple curettage cannot remove the base of polyps [ 19 ]. In this study, the recurrence of EPs in patients undergoing hysteroscopic electrotomy was lower than that of patients with curettage, which is consistent with the literature [ 26 ]. However, the thermal damage of electrotomy cannot be ignored as electrosurgical resection of polyps may lead to endometrial damage and intrauterine adhesion, and there is currently no definite evidence for its applicability to patients with fertility requirements.…”

Section: Discussionsupporting

confidence: 92%

Multivariate Analysis of Recurrence after Hysteroscopic Diagnosis and Treatment of Endometrial Polyps following IVF-ET Failure

Liu

Feng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the risk factors affecting the recurrence of endometrial polyps (EPs) after hysteroscopic diagnosis and treatment of EPs following in vitro fertilization-embryo transfer (IVF-ET) failure by multivariate analysis. Methods. The clinical data of 369 patients with EPs hysteroscopically treated in our department due to IVF-ET failure from January 2017 to January 2020 were retrospectively analyzed, including the number and size of polyps, postoperative treatment, endometriosis (EM), hydrosalpinx (HSP), and polycystic ovarian syndrome (PCOS), and the effects of these factors on EP recurrence were observed. Results. Of the patients enrolled, 184 cases (49.9%) were treated by curettage, and 185 cases (50.1%) by electrotomy. A total of 72 cases (19.5%) of postoperative recurrence were determined, including 34 cases (9.2%) without postoperative medication, 31 cases (8.4%) with one month of postoperative Didroxyprogesterone (DG) administration, and 7 cases (1.9%) with three months of postoperative DG administration. Surgical methods, 3 months of postoperative medication, PCOS, and polyp number and size significantly influence the recurrence of EPs, which were all the influencing factors of polyp recurrence. After controlling for other factors, the risk of EP recurrence after electrotomy was found to be lower than that after curettage, with an odds ratio (OR) (95% confidence interval (CI)) of 0.354 (0.163–0.767); the risk of EP recurrence after 3 months of postoperative medication was lower than that without postoperative medication, with an OR (95% CI) of 0.024 (0.005–0.104); the risk of EP recurrence in patients with PCOS was higher than that without PCOS, and the OR (95% CI) was 2.505 (1.113–5.639); patients with multiple polyps (≥2) were at an increased risk of recurrence than those with a single polyp, with an OR (95% CI) of 66.552 (14.711–301.084); patients with polyp diameter ≥ 2 cm had a higher risk of recurrence than those with polyp diameter < 2 cm, and the OR (95% CI) was 1084.76 (148.743–7910.999). Conclusions. PCOS patients are at an elevated risk of EP recurrence than non-PCOS patients. In patients with multiple polyps, those with a diameter ≥ 2 cm have an increased risk of polyp recurrence compared with those with polyp diameter < 2 cm; electrotomy is associated with a lower recurrence risk of EPs than curettage. The risk of EP recurrence in patients treated with postoperative progesterone for 3 months is lower than that of patients without postoperative medication.

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Section: Discussionsupporting

confidence: 92%

Multivariate Analysis of Recurrence after Hysteroscopic Diagnosis and Treatment of Endometrial Polyps following IVF-ET Failure

Liu

Feng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Limited reports to explore risk factors of polyp recurrence are available, mostly focused on postmenopausal women [1]. Only a few studies conducted in reproductiveage women have suggested some risk factors, such as the duration of follow-up, the number and size of polyps, and sex hormone therapy [2][3][4]6].…”

Section: Introductionmentioning

confidence: 99%

“…Endometrial polyp (EP) is a focal hyperplasia of endometrial basal layer, composing of endometrial glands, vessels, and nearby stroma [ 1 ]. It is a common gynecologic disease with higher prevalence in infertile women [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

LIN28B Polymorphisms Confer a Higher Postoperative Recurrence Risk in Reproductive-Age Women with Endometrial Polyps

Niu

et al. 2022

Disease Markers

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The RNA-binding protein LIN28B is an important factor for cell proliferation. Because LIN28B polymorphisms have been shown to be relative with the recurrence of some hyperplastic diseases, we hypothesized that genetic variants of LIN28B gene were associated with postoperative recurrence risk in reproductive-age women with endometrial polyps (EP). In a hospital-based cohort of 351 reproductive female patients underwent hysteroscopic polypectomies between May 2018 and Jan 2020, we genotyped two common polymorphisms in LIN28B gene ( rs 369065 C > T and rs 314280 A > G ) and analyzed their associations with the risk of postoperative recurrence in multiple Cox regression model. When followed up to Jun 2021, carries of rs369065 TT genotype had an increased risk of polyp recurrence (adjusting hazard ratio HR = 1.883 , 95% confidence interval CI = 1.033 − 3.434 ) and had a shorter time to recurrence (median time 352 vs. 342 days, log-rank P < 0.01 ), compared to the CC/CT genotype. Further stratification analysis showed that the increased risk of rs369065 TT genotype was more evident in patients who were older than 33 years (adjusted HR = 2.597 , 95 % CI = 1.037 − 6.505 ), had a single polyp (adjusted HR = 2.545 , 95 % CI = 1.059 − 6.113 ), and had smaller polyps (<1.2 cm, adjusted HR = 2.708 , 95 % CI = 1.042 − 7.043 ). However, no significant association between rs 314280 A > G polymorphism and the risk of polyp recurrence was found. Our study suggests that rs369065 TT genotype of LIN28B gene is associated with an increased postoperative recurrence risk in EP patients, especially in those with fewer and smaller polyps. These findings implicate a precise choice of clinical counseling and decision making. Larger studies in different ethnic populations are warranted.

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Research Progress in the Treatment of Endometrial Polyps

蔡

2024

ACM

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Effectiveness of different methods for polypectomy in the menopause: a retrospective study

Cited by 3 publications

References 34 publications

Multivariate Analysis of Recurrence after Hysteroscopic Diagnosis and Treatment of Endometrial Polyps following IVF-ET Failure

Multivariate Analysis of Recurrence after Hysteroscopic Diagnosis and Treatment of Endometrial Polyps following IVF-ET Failure

LIN28B Polymorphisms Confer a Higher Postoperative Recurrence Risk in Reproductive-Age Women with Endometrial Polyps

Research Progress in the Treatment of Endometrial Polyps

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