Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study

Chrubasik, Sigrun; Junck, H.; Breitschwerdt, H.; Conradt, Ch.; Zappe, H.

doi:10.1097/00003643-199902000-00008

Cited by 87 publications

(37 citation statements)

References 24 publications

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“…Therefore, inhibitors of elastase activity could help in the treatment of arthritis and rheumatism. This biopharmaceutical quality of the root extract has been proved by clinical study on the treatment of osteoarthiritis pain by Chrubasik et al 72,73) c. Anti-inflammatory Activity Patrinia saniculaefolia HEMSLEY (Valerianaceae) is a perennial herb and endemic in Korea. The roots of this plant and other species of this genus have been used in Korean traditional medicine for treatment of various diseases including inflammation and edema, ap- 157.0 (C-3), 103.1 (C-4), 34.5 (C-5), 26.1 (C-6), 71.1 (C-7), 133.9 (C-8), 43.9 (C-9), 119.9 (C-10), 169.0 (C-11).…”

Section: Biological and Pharmacological Activity Of Naturally Occurrimentioning

confidence: 91%

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Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Debnath²,

2007

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This is a second part of a review 1) and is mainly a compilation of new secoiridoids reported in the literature during 1994-2005 as well as a high-light of biological and pharmacological activity of iridoids and secoiridoids published during 1998--2005. The earlier first part of review 1) included new naturally occurring iridoids (glycosides, aglycones, derivatives and dimers) reported during 1994-2005. Secoiridoids are monoterpenoids based on the 7,8-secocyclopenta[c]-pyranoid skeleton and represented by 1a. They are possibly derived in plants from iridoid, loganin 1b by oxidative cleavage with redox enzyme to 1c and then undergo various secondary modifications of the basic skeleton namely, epoxidation, oxidation, hydroxylation and esterification of the generated hydroxyl groups leading a group of compounds which constitute the class. The main aim of this review is for rapid identification of isolated secoiridoids by comparison of spectral data as well as to draw attention of the natural product chemists for evaluation of biological and pharmacological activity of the isolated iridoids and secoiridoids in order to justify the use of medicinal plants containing these metabolites in folk medicines. In certain plants, the isolated metabolites showed biological activities other than the use of the concerned plants in traditional system of medicine. The high-light of pharmacological activity may possibly draw the attention of the synthetic chemists for design of new drugs using known iridoids as raw materials.A number of review articles on plant secoiridoids are available. Listings of naturally occurring secoiridoids together with spectroscopic data and plant source (review of El-Naggar and Beal covering the literature through January, 1980 2) and of Boros and Stermitz covering the literature through December, 1989 3) ), and without spectroscopic data (review of Hazimi and Alkhathlan covering through December, 1993 4) ) are available. The reviews on biological activity of plant iridoids, namely of Sticher, covering the works reported up to 1976, 5) of Ghisalberti and of Mandal et al. covering the literature up to a part of 1997 6,7) are also available. Secoiridoids are listed in Table 1 in a fashion similar to that of the Boros and Stermitz review.3) All the new secoiridoids are arranged in four groups. Group 1 contains simple secoiridoids; whereas group 2 contains terpene-conjugated secoiridoids; group 3 contains aromatic conjugated secoiridoids and group 4 contains bis-, tris-and tetrakis-secoiridoids. The oxidation state of C-10 and C-11 guides the arrangement of compounds in each group except group 4. The available data for each compound were listed in the following order: name; structure; molecular formula; calculated molecular weight as per atomic weight of most abundant isotopic atoms of C, H, O, etc.; melting point (°C); optical rotation, [a] D (with concentration and solvent); UV (solvent, l max in nm, log e); IR (medium, n max in cm C-NMR data to the first decimal point. Assignments with the s...

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Section: Biological and Pharmacological Activity Of Naturally Occurrimentioning

confidence: 91%

“…Lonicera japonica (Caprifoliaceae). 12) 46.9 (C-9), 118.6 (C-10), 168.4 (C-11), 55.0 (OMe), 97.9 (C-1Ј), 73.0 (C-2Ј), 76.7 (C-3Ј), 70.0 (C-4Ј), 77.0 (C-5Ј), 61.1 (C-6Ј). Gentiana scabra (Gentianaceae).…”

Section: Biological and Pharmacological Activity Of Naturally Occurrimentioning

confidence: 99%

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Debnath²,

2007

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“…Several RCTs were identified on treatments for acute low back pain that were not included in the guidelines: four trials on acupuncture [61][62][63][64], six trials on herbal medicine [65][66][67][68][69][70], one trial on interferential therapy [71], and three References trials on low-level heatwrap therapy [72][73][74]. These interventions were not included in the guidelines, because they were not summarized in a systematic review, involve alternative therapy, or are not commonly used throughout Europe for the treatment of acute low back pain.…”

Section: Other Treatmentsmentioning

confidence: 99%

Chapter 3 European guidelines for the management of acute nonspecific low back pain in primary care

Tulder¹,

Becker²,

Bekkering³

et al. 2006

Eur Spine J

1,149

740

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“…Both of the reviews were published in the Cochrane library and had strong methods and were well reported. These reviews included several randomized controlled trials including a herbal medicine [19][20][21][22][23][24][25][26][27]. Our search for randomized controlled trials resulted in the identification of 149 titles and upon reviewing abstracts and full texts 145 were excluded for various reasons including: not being an RCT, not including a population suffering from chronic NSLBP, not testing an herbal medicine or nutritional supplement, or being included in one of the reviews above.…”

Section: Results Of Literature Searchmentioning

confidence: 99%

“…One review included two RCTs [19,20], both of which included participants suffering from acute exacerbations of chronic NSLBP of greater than 6 months. One review [12] found that there is strong evidence from two high quality RCTs (n=325) that 50 mg harpagoside (the purported active constituent of Harpagophytum procumbens) per dose of an aqueous extract of Harpagophytum procumbens per day reduces pain more than placebo in the short-term [19,20]. In addition, this review reports that there is moderate evidence that 100 mg harpagoside per dose of an acqueous extract of Harpagophytum procumbens reduces pain more than placebo for at least 5 days in the fourth week of treatment [20].…”

Section: Harpagophyum Procumbensmentioning

confidence: 99%

Evidence Based Review of Natural Health Products for Non-Specific Low Back Pain

Gagnier¹

2010

TOPAINJ

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Introduction -Natural health products (e.g., vitamins, minerals, herbal medicines) are frequently used for musculoskeletal pain and there is an increasing amount of high quality research being done to test the efficacy of these interventions. Low back pain is a very common condition and individuals suffering from these conditions are frequently seeking out these products.Objective -The objective of this paper is to review and summarize the evidence surrounding natural health products for chronic non-specific low back pain.Methods -We searched for systematic reviews and randomized controlled trials in PubMed and the Cochrane Library. We performed a best evidence synthesis of the resulting papers.Results -We included two systematic reviews and 2 additional randomized controlled trials published subsequently to these reviews. We found strong evidence for 50 mg harpagoside per dose of an aqueous extract of Harpagophytum procumbens per day reduces pain more than placebo. We found moderate evidence for 100 mg harpagoside per dose of an aqueous extract of Harpagophytum procumbens compared to placebo, for an extract of willow bark yielding 120 mg salicin per day compared with placebo, for 240 mg of salicin per day in reducing pain to a greater extent than placebo, for 240 mg of salicin per day as equivalent to 120 mg salicin, for no differences in pain and function between a 60 mg daily harpagoside dose of an aqueous extract of Harpagophytum procumbens and 12.5 mg rofecoxib per day, for no difference in pain and overall improvement between Spiroflor SRL homeopathic gel (SRL) and Cremor Capsici Compositus FNA, the capsici oleoresin gel, for intramuscular B12 when compared with placebo. We found limited evidence for topical Capsicum frutescens in the form of Rado-Salil cream or a Capsicum plaster for reducing pain more than placebo, for lavender oil in the treatment of chronic NSLBP, or vitamin C, zinc, and manganese in addition to prolotherapy. Adverse events for all interventions appeared to be mild and transient though we did not attempt to identify all relevant literature concerning adverse events.Conclusions -There is some evidence for several natural health products in the treatment of chronic non-specific low back pain. More research is needed for all of these interventions before they are incorporated into routine clinical practice and their reporting must be improved by referring to the recently published extensions of the CONSORT statement.

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Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double-blind study

Cited by 87 publications

References 24 publications

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Naturally Occurring Secoiridoids and Bioactivity of Naturally Occurring Iridoids and Secoiridoids. A Review, Part 2

Chapter 3 European guidelines for the management of acute nonspecific low back pain in primary care

Evidence Based Review of Natural Health Products for Non-Specific Low Back Pain

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