Effectiveness of Quadruple Therapy Using Lansoprazole, Instead of Omeprazole, in Curing Helicobacter pylori Infection

Abstract

The results with lansoprazole-quadruple therapy are comparable to the historic control group treated with omeprazole-quadruple therapy. The cure rare is very high, and although mild to moderate side effects occurred in many patients, everybody finished the treatment regime.

Clinical relevance of resistant strains of Helicobacter pylori: a review of current data

“…When they increased the treatment period to seven days and used lansoprazole instead of omeprazole in 67 patients, the rates were 89 and 100% respectively. 37 Similar results were reported by Hosking et al 41 …”

A randomized trial of standard-dose versus half-dose rabeprazole, clarithromycin, and amoxicillin in the treatment of Helicobacter pylori infection

“…In the mid-1990s, there were suggestions that only regimens which attained an eradication rate of 90% or more should be used in clinical practice [23][24][25]. In 1997, the cut-off between adequate and inadequate therapy was more clearly defined by the Maastricht conferences, where the cut-off was designated as an ITT eradication rate of at least 80% [26].…”

Advantages of Moxifloxacin and Levofloxacin-based triple therapy for second-line treatments of persistent Helicobacter pylori infection: a meta analysis

“…It has been reported that quadruple therapy consisting of a similar combination of antibiotics and a proton-pump inhibitor has repeatedly been shown to be equally eff ective in spite of the presence of metronidazole resistance when the attention was given to the dose of metronidazole (e.g. 400 or 500 mg three times daily) and duration of therapy of approximately 14 days [47][48][49][50][51][52]. So, metronidazole-containing quadruple therapy may have overcome metronidazole resistance to some degree in our studies.…”