Effectivity of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) when male factor is absent: a perspective point of view

Giacobbe, Marcelo; Conatti, M.; Gomes, A.P.; Bonetti, Tatiana Cs; Monteleone, Pedro Augusto Araújo

doi:10.5935/1518-0557.20210031

Cited by 4 publications

(3 citation statements)

References 51 publications

(62 reference statements)

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“…The safety and efficacy of ICSI are yet proven in plenty of studies to overcome different types of male factor infertility. Recently, ICSI has become more common in the treatment of various etiologies of infertility, including older maternal changes, preimplantation genetic testing (PGT), low oocyte yield, fertilization after in vitro maturation (IVM) [3,12,18].…”

Section: Numerical Solutionsmentioning

confidence: 99%

“…Therefore, the second method for male factor infertility is better than the other two methods. (S(0), I(0), G1(0), G2(0), G3(0), K1(0), F1(0), R) = (102, 15,23,67,12,38,32,32), (S(0), I(0), G1(0), G2(0), G3(0), K1(0), F1(0), R) = (317, 153, 95, 179, 43, 99, 80, 52), and (S(0), I(0), G1(0), G2(0), G3(0), K1(0), F1(0), R) = (83, 33,16,55,12,21,18,17), respectively.…”

Section: Numerical Solutionsmentioning

confidence: 99%

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Modeling the diagnosis and control infertility couples with different factors

Ghasemabadi,

Hafezi,

Effati

et al. 2023

Preprint

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Background: There are different etiologies of infertility. Poly Cystic Ovarian Syndrome (PCOS) is a leading cause of infertility among women, and the male factor accounts for about 50 % of the total number of infertile couples. As with various etiologies, various treatments are required. Choosing the most suitable procedure of Assisted Reproductive Technology (ART) for individuals is of great importance. Therefore, mathematical models are needed to estimate the success rate of ART for every individual and to determine which treatment suits the best for each couple. Objective:In this study, we aim to present a new dynamic model that can predict the success rate of ART models for each base on the etiology of their infertility, lab tests, and clinical findings. Materials and Methods For this purpose, 502 participants were recruited and evaluated based on their BMI, AMH levels, the number of transferred embryos, and the etiology of infertility (PCOS, male factor, or both). For this purpose, the community is divided into eight classes: infertile susceptible couples, couples with the cause of infertility PCOS, male factor or both, couples with embryo quality A, B, and C, coupled with the positive βHCG test, couples with the positive result of clinical pregnancy and fertile couples. Results: Our dynamic models evaluate the success rate of ART in our subgroups considering all of the effective factors such as BMI, AMH level, number of transferred embryos, and the etiology of infertility. We have found that (BMI > 30 kg/m2) and low AMH levels (< 3.5ng/mL) indicate lower success rates. Moreover, ICSI was more promising for all the underlying etiologies of male factor, PCOS, or both. Conclusion: In conclusion, our new mathematical model is presented to investigate the dynamics and diagnose the cause of infertility in couples. It is shown that the equilibrium point free of disease is asymptotically stable. In this system, backward bifurcation occurs. When backward bifurcation occurs, we must reduce the primary reproduction number to less than one to eradicate the disease. In our system, we see that the factors that cause the reduction of the primary reproduction number are the factors used to eliminate infertility (the essential reproduction R0 depends on the recovery rate in infertile couples with positive clinical pregnancy (ξ). Therefore, backward bifurcation depends on the possibility of recovery. As the rate of recovery increases, the primary reproduction number R0 decrease and controls couple’s infertility. When male factors and treatment methods cause infertility are IVF and IV F&ICSI, we demonstrate that there is no Hopf bifurcation, i.e., no periodic orbit emerges or vanishes due to a change in the stability of a fixed point.

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Section: Numerical Solutionsmentioning

confidence: 99%

Section: Numerical Solutionsmentioning

confidence: 99%

Modeling the diagnosis and control infertility couples with different factors

Ghasemabadi,

Hafezi,

Effati

et al. 2023

Preprint

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show abstract

“…ARTs involve ovarian stimulation, egg retrieval, in vitro fertilization, embryo culture, and embryo implantation (Chambers et al, 2017). Many new technologies have been introduced in ART in recent decades, including intracytoplasmic sperm injection, preimplantation genetic testing, and time‐lapse monitoring (Giacobbe et al, 2022). However, the assisted reproduction birth rate is no more than 30% worldwide (Gao et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNAs in human reproductive processes and diseases

Zhang,

Sun,

Chen

2024

Molecular Reproduction Devel

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Infertility has become a global disease burden. Although assisted reproductive technologies are widely used, the assisted reproduction birth rate is no more than 30% worldwide. Therefore, understanding the mechanisms of reproduction can provide new strategies to improve live birth rates and clinical outcomes of enhanced implantation. Long noncoding RNAs (lncRNAs) have been reported to exert regulatory roles in various biological processes and diseases in many species. In this review, we especially focus on the role of lncRNAs in human reproduction. We summarize the function and mechanisms of lncRNAs in processes vital to reproduction, such as spermatogenesis and maturation, sperm motility and morphology, follicle development and maturation, embryo development and implantation. Then, we highlight the importance and diverse potential of lncRNAs as good diagnostic molecular biomarkers and therapeutic targets for infertility treatment.

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Reproductive Outcomes of Conventional In Vitro Fertilization and Intracytoplasmic Sperm Injection in Patients with Non-Severe Male Infertility Across Poor and Different Sub-Optimal Ovarian Response Categories: A Cohort Study Based on 30,352 Fresh Cycles from 2009–2019

Jiesisibieke,

Tian,

Zhu

et al. 2024

Reprod. Sci.

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Due to the influence of economic, social and many other factors, there are more and more reproductive problems. Originally introduced for managing male factor infertility, intracytoplasmic sperm injection had become the most commonly used fertilization treatment in the world, with broadened indications including low oocyte yield, prior fertilization failure with conventional in vitro fertilization etc. However, academic evidence for better live-birth outcomes of intracytoplasmic sperm injection over conventional in vitro fertilization is limited. Thus, we aimed to compare the reproductive outcomes of conventional in vitro fertilization and intracytoplasmic sperm injection in patients with non-severe male factor infertility across poor and different sub-optimal ovarian response categories. The fertility rate, implantation rate, clinical pregnancy rate, live birth rate and other obstetric outcomes were mainly compared. Our results showed that independent of the number of oocytes retrieved, intracytoplasmic sperm injection significantly increased the fertilization rate, while conventional in vitro fertilization cycles showed a higher implantation rate, clinical pregnancy rate, and live birth rate. No differences were observed in most obstetric outcomes. Our study indicates that poor ovarian response is not an indication for intracytoplasmic sperm injection in couples with non-severe male infertility.

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Effectivity of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) when male factor is absent: a perspective point of view

Cited by 4 publications

References 51 publications

Modeling the diagnosis and control infertility couples with different factors

Modeling the diagnosis and control infertility couples with different factors

Long noncoding RNAs in human reproductive processes and diseases

Reproductive Outcomes of Conventional In Vitro Fertilization and Intracytoplasmic Sperm Injection in Patients with Non-Severe Male Infertility Across Poor and Different Sub-Optimal Ovarian Response Categories: A Cohort Study Based on 30,352 Fresh Cycles from 2009–2019

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