Effects histamine on pulmonary ventilation in man

Bouhuys, Arend; Jönsson, Ragnar; Lightneckert, S; Se, Lindell; Lundgren, Ceg; Lundin, G.; Tr, Ringquist

doi:10.1007/bf00445124

Cited by 29 publications

(19 citation statements)

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“…Our results show that the guinea-pig resembles other experimental mammals in that vagal reflexes are of considerable importance in these responses. They are consistent with the evidence that in man histamine-induced respiratory and bronchomotor effects depend appreciably on vagal reflexes, and can be ameliorated by therapy that blocks conduction in these pathways (Petit, 1970;Bouhuys et al, 1960 ;Herxheimer, 1956).…”

Section: --H--h -H-h -supporting

confidence: 86%

“…Both these effects are due mainly to a vagal reflex in rabbits (Karczewski & Widdicombe, 1969a) and dogs (de Latona, Mata & Aviado, 1961;de Kock, Nadel, Zwi, Colebatch & Olsen, 1966). In man, the respiratory and bronchomotor actions of histamine are partially or completely blocked by atropine or hexamethonium, which suggests a reflex mechanism (Herxheimer, 1956;Bouhuys, Jonsson, Lichtneckert, Lindell, Lundgren, Lundin & Ringquist, 1960).…”

Section: Introductionmentioning

confidence: 99%

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Role of the vagus nerves in anaphylaxis and histamine‐induced bronchoconstrictions in guinea‐pigs

J¹,

Widdicombe²

1970

British J Pharmacology

135

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Summary1. The effects of vagotomy on the respiratory responses of guinea-pigs to anaphylactic reactions and to intravenous injections of histamine acid phosphate are described. 2. In spontaneously breathing guinea-pigs, vagotomy reduced by 50% or more the decreases in total lung conductance (bronchoconstriction) and the decreases in lung compliance, and almost abolished the rapid shallow breathing due to histamine.3. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by more than 33% the decreases in total lung conductance, but had little effect on the changes in lung compliance due to histamine. 4. In paralysed, artificially ventilated guinea-pigs, vagotomy reduced by 75% the decrease in total lung conductance and halved the decrease in lung compliance due to anaphylaxis. 5. We conclude that a vagal reflex is mainly responsible for the rapid shallow breathing due to histamine, and partly responsible for the bronchoconstrictions due to histamine and to anaphylaxis in guinea-pigs. We suggest that "lung irritant receptors" in the bronchial epithelium are the afferent end-organs involved.

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Section: --H--h -H-h -supporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Role of the vagus nerves in anaphylaxis and histamine‐induced bronchoconstrictions in guinea‐pigs

J¹,

Widdicombe²

1970

British J Pharmacology

135

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“…The significance of histamine in ascaris-induced asthma was confirmed from the present study in which antihistamines were used. A part of airway reactions evoked by histamine are known to occur as the result of the vagal reflex in humans (19)(20)(21), in rabbits (22) and in dogs (23,24) as well as by direct musculotropic action.…”

Section: Discussionmentioning

confidence: 99%

Cardiotonic Action of Ring a-Modified Cardenolides, With Special Reference to Cleavage of the Ring

Yamatake

Sasagawa

Yanaura

et al. 1977

Japanese Journal of Pharmacology

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Abstract-Participationof histamine H1 and H2-receptors in both asthmas, i.e. experimentally induced bronchoconstriction and bronchosecretion, with ascaris suum and histamine in anesthetized dogs was investigated.Dogs given 0.2% histamine solution or ascaris antigen (3 mg protein) by inhalation showed increases in respiratory resistance (Rrs) and respiratory rate to 2.5-5.0 fold. Airway secretion volume was also significantly increased 3-4 fold. The increase in Rrs by histamine inhalation was effectively inhibited or abolished by a histamine HI-receptor antagonist, chlorphenira mine (0.3-1 mg/kg i.v.), but not by a H2-receptor antagonist, cimetidine (1-3 mg/kg i.v.). The increase in Rrs by antigen inhalation was reduced by relatively high doses of chlorpheniramine (1-3 mg/kg i.v.), and not by cimetidine.In contrast, hyperse cretion of tracheobronchial fluid in both asthmas was significantly prevented by either chlorpheniramine or cimetidine. Combinations of both antagonists abolished the hypersecretion.Atropine (2 mg/kg i.v.) significantly inhibited the occurrence of responses in both asthmas. The results suggest that histamine is involved in the allergic asthma produced by ascaris suum and that histamine directly evokes airway constriction through Hl-receptors and hypersecretion of tracheobronchial fluid through H1 and H2-receptors, and, in a part, indirectly activates the cholinergic pathway.There has been much evidence that histamine is the chief chemical mediator released from mast cells during anaphylaxis (1-9).Experimental bronchial asthma in guinea pigs is prominently inhibited by classical antihistamines (10-12). Schild et al. (3) showed un equivocally that histamine release occurs in bronchial tissue of an asthmatic patient.Ash and Schild (13) demonstrated two types of histamine receptors and Black et al.(14) introduced specific antagonists of these receptors which made it possible to characterize and locate these receptors in the body. Data of the presence of H1 and H2-receptors in airway smooth muscle in different species have been documented, and are cited in the review of Chand and Eyre (15). There are, however, specifically no reports on the distribution of these receptors in the dog airway smooth muscle or on the role of these receptors in bron chosecretion. We attempted to characterize histamine receptors responsible for airway constriction and hypersecretion which occurs in ascaris and histamine-induced asthmas, using histamine H1 and H2-receptor antagonists. MATERIALS AND METHODSMale mongrel dogs weighing between 6 and 17 kg were anesthetized with sodium

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“…However, in recent years, it has been reported in human beings (10,11) (7) and Yamatake et al (9) that the airway constrictions evoked by allergens are significantly inhibited by atropine, surgical vagotomy, or vagal cooling blockade. In this way, following the clarification of the role played by the vagus nerves in bronchial asthma, atropine-like drugs are recently being evaluated as anti asthmatic drugs, and ipratropium bromide, etc., have been developed.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, it has been reported by Gold et al (7), Yu et al (8) and Yamatake et al (9) that the allergic bron choconstriction is inhibited by atropine or vagal blockade. Furthermore, it has been reported in human beings (10,11) and animals (12)(13)(14) that the vagal reflex is also involved in the airway constriction induced by histamine. These facts suggest that the vagal reflex plays an important role in various airway responses, including asthma.…”

mentioning

confidence: 99%

Effects of 8-(2-fluoroethyl)-3.ALPHA.-hydroxy-1.ALPHA.H, 5.ALPHA.H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas.

et al. 1983

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Abstract-The effects of Ba598Br , a new atropine derivative possessing a quarternary ammonium salt structure, on the canine airway, including its antiasthmatic effects , were investigated. The in vivo airway resistance was determined using the modified Konzett Rossler method. Inhalation of 0.01 % of Ba598Br had an inhibitory effect against acetyl choline (ACh, 10 Sag/kg i.v.)-evoked bronchoconstriction. The effect of Ba598Br was more powerful and longer lasting than that of the same dose of atropine. Pretreatment with Ba598Br (0.3%) and atropine (0.3%) by inhalation produced a remarkable inhibitory effect on the asthmatic bronchoconstriction induced by inhalation of Ascaris swum antigen in naturally sensitized dogs. In this case, Ba598Br showed a potency of approx. twice that of atropine as estimated from the inhibitory percent. On the other hand, in the case of posttreatment (drugs being inhaled after the antigen inhalation), both drugs showed inhibitory effects of equal degree. As for the effects on increased airway secretion at the time of asthmatic attack, both drugs inhibited the excessive secretions without any remarkable change in the viscosity of the secretions. Inhalation of 0.3% Ba598Br showed a powerful antihistamine action with respect to histamine (Hist, 3 ,tg/kg i.v.) induced bronchoconstriction after the bilateral cervical vagi and superior laryngeal nerves were amputated. However, almost no effect could be observed with the same dose of atropine. Both Ba598Br and atropine showed relaxing actions of the same degree against ACh contraction on the isolated canine trachea, bronchus and bronchiole preparations, with a particularly strong relaxation being observed in the bronchiole. On the other hand, Ba598Br showed relaxing actions against histamine-induced con tractions, which were more powerful than those of atropine, in the bronchus and bronchiole. From the above findings, it is suggested that the Ba598Br inhalation brings about antiasthmatic effects by its persistent, powerful anticholinergic actions and its transient but powerful antihistamine actions.

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Effects histamine on pulmonary ventilation in man

Cited by 29 publications

References 0 publications

Role of the vagus nerves in anaphylaxis and histamine‐induced bronchoconstrictions in guinea‐pigs

Role of the vagus nerves in anaphylaxis and histamine‐induced bronchoconstrictions in guinea‐pigs

Cardiotonic Action of Ring a-Modified Cardenolides, With Special Reference to Cleavage of the Ring

Effects of 8-(2-fluoroethyl)-3.ALPHA.-hydroxy-1.ALPHA.H, 5.ALPHA.H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas.

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