Effects in man of single and combined oral doses of reserpine, iproniazid, and <i>D</i>‐lysergic acid diethylamide

DeMaar, Edmund W. J.; Williams, Harry L.; Miller, A. I.; Pfeiffer, Carl C.

doi:10.1002/cpt19601123

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Pretreatment with nialamide, a different MAOI, daily for 3 weeks to reach a total dose of 3500 mg also blocked the effects of LSD and patients tolerated very high doses of LSD at 500 μg without any clinical or psychotic symptoms (Grof & Dytrych, 1965). In contrast, iproniazid at 100 mg, when taken together with varying doses of LSD, did not alter any physical or subjective effects of LSD (DeMaar et al, 1960).…”

Section: Antidepressants (Maoi): Isocarboxazid Phenelzine Nialamide A...mentioning

confidence: 91%

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Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

Halman

Kong

Sarris

et al. 2023

Preprint

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Classic psychedelics, lysergic acid diethylamide, psilocybin, mescaline and N,N-dimethyltryptamine, are potent psychoactive substances that have been studied for their physiological and psychological effects. However, our understanding of the potential interactions and outcomes when these substances are used in combination with other psychoactive drugs is limited. This systematic review aims to provide a comprehensive overview of the current research on drug-drug interactions between classic psychedelics and other psychoactive drugs in humans. We conducted a thorough literature search using multiple databases, including PubMed, PsycINFO, Web of Science and other sources to supplement our search for relevant studies. A total of 8,487 records published before April 20, 2023, were screened, and studies involving human data describing potential interactions (as well as the lack thereof) between classic psychedelics and other psychoactive drugs were included. In total, we identified 34 reports from 50 studies, encompassing 31 studies on LSD, 11 on psilocybin, 4 on mescaline, 3 on DMT and 1 on ayahuasca. These studies provide insights into the interactions between classic psychedelics and a range of drugs, including antidepressants, antipsychotics, anxiolytics, mood stabilisers, recreational drugs and others. The findings reveal various effects when psychedelics are combined with other drugs, including both attenuated and potentiated effects, as well as instances where no changes were observed. With the exception of a few case reports, no significant adverse drug reactions were discovered in the studies included. In-depth discussions of the results are presented, along with an exploration of potential molecular pathways that underlie the observed effects.

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Section: Antidepressants (Maoi): Isocarboxazid Phenelzine Nialamide A...mentioning

confidence: 91%

“…The first three listed antidepressants attenuated or blocked the effects of LSD Grof & Dytrych, 1965;Resnick et al, 1964). In contrast, the latter, 43 iproniazid, did not alter the subjective or physical effects of LSD (DeMaar et al, 1960).…”

mentioning

confidence: 85%

Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

Halman

Kong

Sarris

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The first three listed antidepressants attenuated or blocked the effects of LSD Grof and Dytrych, 1965;Resnick et al, 1964). By contrast, the latter, iproniazid, did not alter the subjective or physical effects of LSD (DeMaar et al, 1960). However, iproniazid was also used in the experiments with DMT where it was shown to reduce the effects of DMT (Sai Halasz, 1963).…”

Section: Monoamine Oxidase Inhibitorsmentioning

confidence: 99%

Drug–drug interactions involving classic psychedelics: A systematic review

Halman,

Kong,

Sarris

et al. 2023

J Psychopharmacol

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Classic psychedelics, including lysergic acid diethylamide (LSD), psilocybin, mescaline, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), are potent psychoactive substances that have been studied for their physiological and psychological effects. However, our understanding of the potential interactions and outcomes when using these substances in combination with other drugs is limited. This systematic review aims to provide a comprehensive overview of the current research on drug–drug interactions between classic psychedelics and other drugs in humans. We conducted a thorough literature search using multiple databases, including PubMed, PsycINFO, Web of Science and other sources to supplement our search for relevant studies. A total of 7102 records were screened, and studies involving human data describing potential interactions (as well as the lack thereof) between classic psychedelics and other drugs were included. In total, we identified 52 studies from 36 reports published before September 2, 2023, encompassing 32 studies on LSD, 10 on psilocybin, 4 on mescaline, 3 on DMT, 2 on 5-MeO-DMT and 1 on ayahuasca. These studies provide insights into the interactions between classic psychedelics and a range of drugs, including antidepressants, antipsychotics, anxiolytics, mood stabilisers, recreational drugs and others. The findings revealed various effects when psychedelics were combined with other drugs, including both attenuated and potentiated effects, as well as instances where no changes were observed. Except for a few case reports, no serious adverse drug events were described in the included studies. An in-depth discussion of the results is presented, along with an exploration of the potential molecular pathways that underlie the observed effects.

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“…"76 It is now believed that pharmacologic tests such as potentiation of amine effects ( in animals) or the "tryptophan intoxication syndrome" (in man) are the only valid measures of drug action inhibiting brain monoamine oxidase." '3 De Maar and colleagues 84 undertook a well-controlled pharmacologic study in man with the purpose of determining the relation of iproniazid and reserpine effects to those elicited by lysergic acid diethylamide. Two principal findings emerged: subjects clearly discriminate between effects of lysergic acid diethylamide on the one hand and those of combined reserpine and iproniazid administration on the other; and addition of either reserpine or iproniazid to lysergic acid diethylamide does not alter the effects of the latter drug.…”

Section: Some Commentsmentioning

confidence: 99%

Clinical pharmacology of central stimulant and antidepressant drugs

Werner

1962

Clin Pharma and Therapeutics

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Department of Pharmacology, Cornell University Medical CollegeThis survey illustrates the interdisciplinary nature of psychopharmacologic research. In order to conduct meaningful psychopharmacologic inquiry, a variety of different conceptual and methodic frames of reference must be drawn upon. Lehmann 208 effectively emphasized the eclectic nature of experimental design in psychopharmacology-a design that must critically employ appropriate controls and statistical validation, that must do justice to biochemical, neurophysiologic, and behavioral mechanisms of drug action, that must be sensitive to the dynamics of personality functions, and that must respect the fundamentals of dose and time parameters of drug action. These, then, are the ingredients out of which experience and imagination can shape effective tools to obtain conclusive answers to speCific and meaningful questions on drug effects or normal and pathologic behavior and personality functions. In the beginning was the hypothesisOn the basis of certain, mostly biochemical, key events, three different hypotheses of normal and abnormal behavior have been put forward in the past. While the validity of these hypotheses did not remain uncontested, everyone of them has led to practical developments for drug treatment of pathologically depressed personality functions. In fact, most of the clinical reports on antidepressive drug actions are, in concept of study and interpretation of results, committed to one or another of these hypotheses. In general terms, these hypotheses embody the concept of neurohumoral transmission and receptor specificity in the' central nervous system. The existence of three types of receptors within the brain, related to the physiologic turnover of three types of substrates, has been inferred.'4. 96 Serotonin hypothesis. Originally, the implication of serotonin ( 5-hydroxytrypta- 59

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Effects in man of single and combined oral doses of reserpine, iproniazid, and D‐lysergic acid diethylamide

Cited by 6 publications

References 3 publications

Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

Drug-drug interactions between classic psychedelics and psychoactive drugs: a systematic review

Drug–drug interactions involving classic psychedelics: A systematic review

Clinical pharmacology of central stimulant and antidepressant drugs

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